I've been taking a break from LDN (after three months on it)...since I was having some issues that seemed like side effects to the LDN. However, I do plan to go back on it after a break. The biggest thing I've noticed now that I've been off it a week or so is that my generalized muscle pain has come back big time. I hadn't fully realized how much the LDN had brought pain relief because it just gradually faded and I forgot how much pain I had been dealing with. Once things have "calmed" a bit in my system, I'm eager to get back on the LDN for the pain relief and more restorative sleep.