LDN or Naltrexone 4.5mg I have been taking low dose Naltrexone 4.5mg for several months now. My Doctor suggested it because I was having a flare up of nerve pain in my legs. I felt as if my central nervous system was overwired. He said that his patients with MS do quite well also on it. Initially each month that I was on it I had less pain than before. He said it heals the nerve endings and grows myelin sheath. I started around March 2009. Now, at the end of August 2009, I would say that my overall body pain is the lowest that it has been in the last 19 years since I got Fibromyalgia and Chronic Fatigue/ME. I also had 3 car accidents during that time which meant I had a couple of years where I was taking things such as Oxycodone and then trammadol. When he told me that I had to be off of all pain medication for 10 days before I could start the LDN I didn't think I would be able to handle it. I am quite amazed at how it has reduced my pain. I believe that during this time I have also greatly increased my exercise. I swim a few times a week, (10 - 20 laps in a 60ft pool), walking up to 3 miles a few times a week, and swing dancing again. I cannot just do one of these things every day. It has to be paced. I don't do all of the laps at once. I do a couple, rest and then do a couple more. If I have had a high activity day the day before, I stick to 10. If not, then I do 20. If I walk a long distance one day, I don't swim. If I am going dancing that night, I don't swim or walk that day. I can't just do it all without being very careful, Sometimes I start out on a walk that I think will be about an hour long, and after 10 minutes I'm done. I guess I just really don't know what I'm going to get on any given day. However, when you look at the months and years of inactivity when any one of those things was impossible, then it is a great accomplishment. Sometimes I have a good 2 - 3 weeks, and then the 4th week I can't exercise at all. It all has to be paced, at whatever level your body is at that day, or week. I do believe the low dose Naltrexone helped me to get to that level. My experience with low dose Naltrexone has been 100% positive, and I would encourage others to try it.