I took my first .5 mg LDN Saturday night at 9. Within an hour I had a headache and by morning it was slamming and I had some nausea. I took a total of 100 mgs sumitripton around 10 a.m. which took the edge off but I had a headache for 24 hours. I spoke to the pharmacy and he told me he's never heard of this kind of reaction. He used Avicel as the filler. In 2008 I got some LDN from Irmat and I don't remember having this kind of reaction. I don't know what filler the use. I'm hoping it's the filler vs the LDN itself. I guess I'll have to try it again by opening the capsule and taking a really small amount. Has anyone else had this problem? Nothing was really different about that day and what was I've ruled out.