I have classic EDS so probably represent a small subpopulation on this forum (unless everyone with CFS has undiagnosed collagen mutations). Fatigue and background pain levels are unacceptable and have been for some time. I have tried tons of supplements and medications in the past with minimal success. I haven't tried LDN or kratom LDN requires a scripti but kratom does not. I like the background mechanism for LDN better and generally feel skeptical about any herbal supplement touted as a miracle cure for fatigue and pain. But that being said, I would like to hear from people about both. It would be great if you have compared them. I am still leaning towards LDN but am open to ideas.