This study i found shows low dose hydrocortisone reduces inflammatory cytokines TNF-α, IL-6, IL-8, and IL-1β with out impairing neutrophil function which killed Staphylococcus aureus or Escherichia coli . http://www.ncbi.nlm.nih.gov/pubmed/21430601 Also in the book 'the safe use of cortisol' it shows that viral infection lower hpa axis function and by treating this with low dose (physiological doses)hydrocortisone improves immune function by increasing igm and igg immunoglobulins. Pharmocological doses were found to have immune supression affects but the opposite was found in humans with physiological doses. It also mentions in the book that many infections lower hpa axis function and the worse the infection the greater the function is lowered. After reading this book it seems that balance is the key as well as using more natural hormones like hydrocortisone rather then synthetic prednisones etc. Maybe we have been brain washed into thinking cortisol therapy suppresses the immune system and cause osteoporosis, which it does in high doses but in replacement doses it improves immune function. Dr jefferies who wrote 'the safe use of cortisol' doesnt come across as a quack. It sounds like he was there when cortisol treatments first started way back when and has over 40 years experience using this type of treatment for a variety of condition, he as also worked for a number of high profile institutions. It does seem to match up alot with cfs/me with our immune/infection as well as autoimmune tendencies and adrenal dysfunction??