Hello. The only drug which really help me and almost solve all my CFS with hypersomnia symptoms is Provigil. I'm quite lucky because a lot of people with CFS see no improvements with Provigil. The problem , as i already wrote in another post here in Phoenix Rising, is that i have great dehydration and little tachicardia and i build tolerance very quickly, i.e. at the third day it has no effect, so i can use it only twice a week. The endocrinologist encountered a secondary hypoadrenalism and they prescribed me 37.5 acetate cortisone / day. I know a lot of studies about CFS warning about use low-dose hydrocortisone for the well-know adrenal suppression effect. I'm writing now for another reason. I'ld like to know if any other here in the forum has got improvements with low-dose hydrocortisone, with what dosage and after how many weeks/ months and if anyone is also taking Provigil along with hydrocortisone and has side-effects (the worst the exaggerate dehydration and some discomfort in the phalanges of the hands. Thanks for any comment and answer. Fabio.