My doctor told me yesterday that one reason that I am in perimenopause is because my cholesterol is so low. When the cholesterol is so low, you then don't make estrogen or progesterone. It affects all hormonal production. I was told this when I was 26 too. I am soon to be 40. It affects the adrenals too. This has been an ongoing problem for me. He says that the cytokines become excited due to such low hormones and this is why I have chronic pain. I did some research, and I read that low cholesterol can go along with suicidal thinking and depression, which is what I have been experiencing as well. People with low cholesterol fail to thrive. He said it is a conversion problem. I went and bought some liver to eat. GROSS! Has anyone else had this problem?