I am interested in collecting info about PWME with the above concurrent markers, i.e., both low CD4 and low NK (both out of range). Am I wrong or it seems it is the minority of PWME, can we talk about a "sub-type" here? (1) Could you indicate the severity of your ME condition & co-morbidities, when you became ill, and the kind of onset you experienced (acute/gradual)? (2) What have you discarded in differential diagnosis? (3) What else have you tested positive for? (in my case, IgG+ for EBV and for CMV so far, no titers available; I assume IgG + for VZV as well, since I had Chickenpox) (4) Is your treatment focused on increasing CD4 and/or NK or is it centered in something else? (5) What has proven effective in increasing CD4 and/or NK? For how long have you used them? (6) Have your symptoms improved due to CD4 / NK boosters? I hope the info collected could be useful for PWME low CD4 low NK Thanks for responding!