My blood biochem. test results from last week have come back showing my "anion gap" result is abnormal and two numbers below the normal range. On researching this I've found out low anion gap is uncommon. Im wondering if others with CFS have had an abnormal result in this area??? Could it be related to the CFIDS???? What further is confusing about this is I have very low D3 and in my research on anion gap I saw that D3 deficiency affects anion gap the other way to my results and would make my anion gap result higher (not lower) than it would be without a D3 deficiency.. so i guess my anion gap would be showing as even more abnormal then it is now if i didnt have a possibly severe again, D3 deficiency affect it the other way. (doctor gave up trying to correct my D3 deficiency as it went even lower after supplementation so ive no idea what it is now as its been a long while since we gave up with trying to supplement). from http://www.haps.nsw.gov.au/Research/Communique_List/Anion_Gap.aspx What is the clinical significance of a low anion gap? There are three possible causes of a decreased anion gap, decreased unmeasured anions circulating in the blood (usually low protein, especially hypoalbuminaemia), increased unmeasured cations (e.g. hypercalcaemia or an atypical IgG myeloma cation), and laboratory error. 1.Decreased unmeasured anions Severe Hypoalbuminaemia Nephrotic syndrome Protein-losing enteropathy Exfoliative dermatitis Malnutrition 2.Increased unmeasured cations Hypercalcaemia - hyperparathyroidism, malignancy, excess Vitamin D Hypermagnesaemia (rare) Increased unusual cations Atypical IgG myeloma proteins 3.Laboratory error ......... I are not malnorished (im eatting a lot and well, have gained weight), I havent got Hypoalbuminaemia, dermatitis, dont fit the Nephrontic Syndrome (thou i do have hyperlipidemia), my calicum and magnesium levels are normal. Maybe my result is a lab error??? Thou if my bicarb. level went up one level more then that would be in the abnormal range so i guess my bicarb level would of pushed the anion gap level down some? On that link i gave it says "increased unusual cations" can cause a low anion gap result. Does anyone know of anything to do with CFIDS which is a cation which could be floating about in my body and affected this test???? My other question is on multiple myelona (cancer of the white blood/plasma cells) which i read also can cause a low test result of anion gap .. if i had something like that developing after 13 years of CFIDS.. would abnormalities show up on the normal general haematology blood tests the doctors do???? (my calicum levels are fine, im not currently suffering from any bone pain thou have done in past, i dont have anemia, blood iron levels fine thou for some reason on more in depth iron testing my test came out as abnormal and said i had no iron stores.. i just eat meat 2-3 times per day so that result surprised me and seemed strange). Im still a little concerned about the low anion gap result as I think I remember reading of one with CFIDS dying from multiple myelona on a CFIDS death list (wrong diagnoses??? or caused by CFIDS??). And every year I get something else going wrong with me. Anyone else here finding they have good iron blood levels but no iron stores in body??? could this be a CFIDS thing???