I've been trying to get a tilt table test to establish a POTS diagnosis but it's taking a long time. I've got preexisting mental health issues, and I've had some success with antidepressants notably nortriptyline (Pamelor) and to a lesser extent other NET inhibitors (Straterra, Cymbalta). They all have side effects that are too much, I can't think with the anticholinergic effects of nortriptyline and I get too nervous and sleepless on Straterra and Cymbalta. I'm beginning to think that the alpha adrenergic agonizing effects of these meds is why I've done well on them, and that's what I understand can help with POTS. Without actually having a POTS diagnosis, what's med or two that I can try for help? What has helped you guys now or in the past? I've tried beta blockers, I almost passed out with just having them in my mouth. Cipro really threw me for a loop when I took it last year, still dealing with fatigue/ mitochondrial dysfunction? since then, so beta blockers are risky.