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ME/CFS: A disease at war with itself
We can all agree that ME/CFS is a nasty disease, particularly in its severe form, but there are abundant nasty diseases in the world. What is unique and particularly confounding about our disease is that so much controversy surrounds it, and not only surrounds it, but invades it too.
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Longitudinal MRI study in CFS patient: a CDC criteria study

Discussion in 'Latest ME/CFS Research' started by shrewsbury, Mar 21, 2010.

  1. ixchelkali

    ixchelkali Senior Member

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    Long Beach, CA
    Another GIGO study

    None of the CFS patients were considered to be from the extreme end of the symptomatic spectrum (i.e. bedridden or with intense sensitivity to any external stimuli).

    So first they use the Fukuda criteria, and then they didn't have any patients with obvious neurological defects. Yeah, Jimmie, they looked hard and they still couldn't find it...

    Even if the authors of the study were legitimately trying to find a marker, it's not going to work when your patient cohort is corrupted by a flawed case definition. To quote Leonard Jason in his just-published study Sensitivity and Specificity of the CDC Empirical Chronic Fatigue Syndrome Case Definition, "the scientific enterprise depends on reliable and valid ways of classifying patients into diagnostic categories, and this critical research activity can enable investigators to better understand etiology, pathophysiology, and treatment approaches for CFS and other disorders. When diagnostic categories lack reliability and accuracy, the quality of treatment and clinical research can be significantly compromised."

    In other words, garbage in, garbage out.
  2. Jerry S

    Jerry S Senior Member

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    Chicago
    Yep, ixchelkall. It's hard to believe that after 25 years, the CDC still doesn't have an adequate case definition for their CFS. Even 1994 Fukuda is deeply flawed.

    The new Jason paper completely demolishes any claim that Reeves' empirical definition is credible.
  3. John H Wolfe

    John H Wolfe Senior Member

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    London
    This article appears to set the record straight, making direct reference to Perrin's study:

    http://www.birpublications.org/doi/abs/10.1259/bjr/93889091

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