Another GIGO study None of the CFS patients were considered to be from the extreme end of the symptomatic spectrum (i.e. bedridden or with intense sensitivity to any external stimuli). So first they use the Fukuda criteria, and then they didn't have any patients with obvious neurological defects. Yeah, Jimmie, they looked hard and they still couldn't find it... Even if the authors of the study were legitimately trying to find a marker, it's not going to work when your patient cohort is corrupted by a flawed case definition. To quote Leonard Jason in his just-published study Sensitivity and Specificity of the CDC Empirical Chronic Fatigue Syndrome Case Definition, "the scientific enterprise depends on reliable and valid ways of classifying patients into diagnostic categories, and this critical research activity can enable investigators to better understand etiology, pathophysiology, and treatment approaches for CFS and other disorders. When diagnostic categories lack reliability and accuracy, the quality of treatment and clinical research can be significantly compromised." In other words, garbage in, garbage out.