@Freddd I've noticed you have been taking some heat recently, so I thought it would be a good time to express my thanks for all the great information you have freely given over the years. The same thanks go to Kevin, Red and a number of others that posted on the old Wrong Diagnosis thread. I don't have any questions, but I'll try to give you a brief history in case an extra data point is useful. I found the Wrong Diagnosis thread after experiencing a couple crashes the previous year. It would take about a week to recover if I rested. To this day the crashes still perplex me. I don't have CFS ( based on my own opinion ), but the symptoms I've experienced are awfully similar. During the crashes, I was simply not able to think. I remember I had to do some simple addition and subtraction so I could cut some boards to a proper length, and i would repeatedly get it wrong. Exhaustion was also there. The worst part was that I would spend most of the day thinking how difficult the next task was going to be. The simplest things just became so overwhelming. I am not exaggerating when I say, I would get one hours work done in 8 hours, and I would fret and make mistakes the whole way through. Another big symptom I have had the last few years is extremely sore muscles after exercise. The onset of soreness was usually 24 hours or more after the exercise but would last for few days. I thought that was normal at the time. Lastly, I was experiencing some numbness mostly in my hands, but some in my feet. The numbness would usually be brought about by cold ( nowhere near freezing, but cold for someone from California ) or positioning, or holding a position to long without moving. I would often wake up with both arms completely numb from the shoulder down. I have great sympathy for many of the posters on this site. I know the difficulties I had are just a fraction of what many of you have experienced. I tried to start Freddd's protocol around the time Jarrow went bad. The bad Jarrow along with folic acid instead of Metafolin did nothing for me. When the enzymatic therapy and metafolin finally showed up a few weeks later, I had an amazing reaction. My energy went through the roof, and I lost most of the post exercise fatigue. Work became so much easier. Those great heights did not last more than a week, and I had deal with paradoxical folate deficiency and low potassium. But I got through the worst of it thanks to Freddd's postings. For the past year or so I've felt I was always near the edge of folate deficiency. I have been taking 4 to 5 mg of metafolin a day. Angular cheilitis was never bad, but always seemed to be a touch there or right around the corner. In fact a few months ago at the dentist, the hygienist had to deal with a little blood from the crack which showed up at the corner of my mouth after opening wide. I happy to say after moving to the low dose Nature Made B complex Freddd suggested, there is no sign of angular cheilitis or any other folate deficiency. I can't remember the last time I've had any numbness, and my muscles hardly ever get sore. I'm currently taking the basics and the quartet, and have no intention of stopping. Freddd, your work is greatly appreciated.