Hello all, I am a new user and have been reading many of the threads here, looking for information, as I believe I am quite overmethylated and possibly experiencing methyl trapping. I stumbled upon this thought recently after learning about the various methylation protocols. I was put on 5-MTHF by a doctor a couple of years ago (1mg/day, then 5mg/day, for anxiety--I am bipolar), but stopped seeing her because I objected to her insistence that I become vegetarian. I tried it at her recommendation for a while and became B12 deficient. My new doctor has given me B12 shots. I am +/- for C677T. I have a LiveWello/23andMe report if you are curious about anything else. My anxiety has been through the roof lately. I now realize I have many of the symptoms of overmethylation. I have had severe food sensitivities out of nowhere for years, I am anxious and paranoid, etc. I also have many of the symptoms of B12 deficiency. I am taking sublingual B12. I am also taking Niacin every few hours and as much potassium as I can--I am deficient, likely because I am on lithium. I have the other things on hand to start methylation again when it is time. Okay, my questions: 1. Will it take me a long time to get out of this situation? Do I just keep taking niacin for a while? 2. How do I know when it's time to stop taking niacin? 3. Does the food sensitivity reverse when the overmethylation ends? I am wondering whether I can look to that as a sign, and also whether I'll need to do any gut repair. Thanks. I'm sorry if these things have been answered before--a lot of the answers I have read seem to apply to shorter-term overmethylation so I would appreciate help in being pointed in the right direction.