1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
New Exercise Study Brings Both Illumination and Questions
Simon McGrath looks at new objective evidence of abnormal response to exercise in ME/CFS patients, and the questions that researchers are still trying to answer ...
Discuss the article on the Forums.

List of XMRV Research Studies

Discussion in 'XMRV Research and Replication Studies' started by Bob, Jun 24, 2011.

  1. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    This list was last refreshed on 1st August 2011.

    I've aimed to make this a comprehensive list, hopefully including all of the high profile studies relating to XMRV/CFS, but there maybe studies that I've overlooked.

    Any suggestions for additional info, corrections and improvements are very welcome.


    Within each category, the papers are listed in order of the date of publication.


    Contents:

    XMRV in CFS Patients - Published positive studies
    PMRV in CFS Patients - Published positive studies
    XMRV in CFS Patients - unpublished positive studies abstracts & reports
    XMRV in CFS Patients - future studies
    Other published positive XMRV studies (Not CFS or Prostate cancer)
    Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)
    XMRV/Human DNA integration papers
    Conferences - and lists of abstracts
    Investigative XMRV studies
    XMRV & CFS Patients - Published negative studies
    Inconclusive studies & studies that add some knowledge about XMRV
    Overviews of XMRV research
    Reviews
    Letters to Scientific Journals
    Blood Related Studies & Reviews
    Patents applied for
    Positive XMRV Prostate Cancer studies
    Unpublished Positive XMRV Prostate Cancer studies
    Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)
    Negative XMRV Prostate Cancer Studies (No XMRV detected)
    Negative XMRV studies other
    Contamination studies and theories
    Papers that provide evidence against contamination theories
    MLV Recombination Theory studies
    Other negative studies (Not CFS or Prostate cancer)
    Science Journal editorial Expression of Concern.
    Historical research looking at MLV-related viruses associated with human disease
    Antiretroviral Research
    Related/Relevant HIV Research
    Related/Relevant HTLV Research
    Other research related to XMRV/CFS
    XMRV Sequences in genbank
    Other information
    Comparison Tables XMRV research studies
    Conference Abstracts (A small selection of abstracts)
    Student Theses relating to XMRV
    Other resources




    XMRV in CFS Patients - Published positive studies

    Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome
    Vincent C. Lombardi, Francis W. Ruscetti, Jaydip Das Gupta, Max A. Pfost, Kathryn S. Hagen, Daniel L. Peterson, Sandra K. Ruscetti, Rachel K. Bagni, Cari Petrow-Sadowski, Bert Gold, Michael Dean, Robert H. Silverman, and Judy A. Mikovits
    Published Online 8 October 2009
    Published in Science 23 October 2009
    Science
    http://www.sciencemag.org/content/326/5952/585.abstract
    Addendum:
    http://www.landesbioscience.com/journals/virulence/MikovitisVIRU1-5.pdf
    Supplementary material:
    http://www.ncbi.nlm.nih.gov/pubmed/20842203




    PMRV in CFS Patients - Published positive studies

    Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
    Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. Komaroff, Guo-Chiuan Hung, Richard Wang, and Harvey J. Alter
    Published online before print August 23, 2010
    PNAS
    http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf html
    Results: 86.5% in CFS patients. 6.8% in healthy volunteer blood donors.




    XMRV in CFS Patients unpublished positive studies abstracts & reports

    Anything other studies to add here?

    Detection of infectious XMRV in the peripheral blood of children
    M A Pfost et al.
    (WPI)
    Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
    http://regist2.virology-education.com/abstractbook/2010_8.pdf
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    Detection of infectious XMRV in the peripheral blood of chronic fatigue syndrome patients in the United Kingdom.

    Mikovits et al.
    (WPI)
    Initial results reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
    http://regist2.virology-education.com/abstractbook/2010_8.pdf
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    XMRV detection in a national practice specializing in CFS
    P Cheney
    Using the VIPdx lab, 74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    Detection of MLV-like gag sequences in blood samples from a New York state CFS cohort
    Maureen R Hanson, Li L Lee, Lin Lin, David E Bell, David Ruppert and David S Bell
    Initial reported results = 80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences, and 1% of healthy controls. (Reportedly finding PMRV rather than XMRV.)
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
    http://www.cfids.org/xmrv/wrkshp-report.pdf
    http://www.biomedcentral.com/content/files/pdf/1742-4690-8-S1-full.pdf
    http://www.retrovirology.com/content/8/S1/A234
    An extract from:
    Of Mice and Men: A Summary of the First International XMRV Workshop.
    by K. Kimberly McCleary with Steven H. Kleinman, BSc, MD, and Suzanne D. Vernon, PhD.
    Dr. Hansons study tested samples obtained by David S. Bell from 20 CFS patients, 10 of whom reported having recovered but still demonstrated lower physical activity levels than the 10 healthy control subjects as measured by seven instruments employed by Dr. Bell. Of these 20 CFS patients, 11 (55%) were positive; 8 (80%) of the 10 patients currently meeting Fukuda criteria and 3 (30%) of the individuals who had recovered tested positive, compared to 1 (10%) of the 10 healthy controls. The gag sequences found by Dr. Hanson were more similar to those reported by Lo et al., than to the gag sequences for XMRV, although all are part of the same gammaretrovirus family. Her group is working to sequence the env sequence and the entire virus genome(s) now that they have external funding support from NIH.

    http://www.cfids.org/xmrv/wrkshp-report.pdf

    Kenny De Meirlier
    Blinded study, using the VIPdx to test for XMRV
    Initial reported results = XMRV detected in 57% of 84 CFS patients, and in 14% of 50 healthy donors.
    http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm

    Wilfried Bieger (Germany)
    Reported positive study, to be published sometime in 2011.
    Detecting XMRV in 20% to 40% of 110 CFS patient samples.
    http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm
    http://www.facebook.com/notes/xmrv-...-40-of-a-cohort-of-110-peop/10150253684766797




    XMRV in CFS Patients - Future studies

    The Norwegian study of CFS, NO-CFS, Stage 1: Confirmatory study for the detection on Gamma-retrovirus related Gene Sequences.
    http://esme-eu.com/news/the-norwegi...irus-related-gene-sequences-article487-7.html
    http://lhkpasientfora.org/wp-conten...krivelse_eng_NO_CFS_stage-one_XMRV-study1.pdf

    Blood Working Group
    link to info needed

    Ian Lipkin
    link to info needed

    Dr. Frank Maldarelli
    NIH - National Cancer Institute
    The study will take blood samples from 60 people, divided equally between people who previously tested XMRV-positive and healthy individuals.
    The data will be used to help formulate a gold standard for determining positive and negative results.
    http://www.phillyburbs.com/blogs/wo...b-7981-56f2-b829-af35a545728e.html?mode=print




    Other published positive XMRV studies (Not CFS or Prostate cancer)

    Xenotropic Murine Leukemia Virusrelated Gammaretrovirus in Respiratory Tract
    Nicole Fischer, Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Christian Drosten, and Martin Aepfelbacher
    June 2010
    Emerg Infect Dis. 2010 Jun; DOI: 10.3201/eid1606.100066
    http://www.cdc.gov/eid/content/16/6/1000.htm
    (We detected XMRV in respiratory secretions of immunocompetent patients with and without RTI at a frequency of ?3.2%, which is in good concordance with the recently reported prevalence in the general population of up to 4%)

    The Prevalence of XMRV in Healthy Blood Donors in Japan
    XMRV reportedly found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
    "Although our study had a limited sample size, the prevalence among blood donors as determined by identifying XMRV-specific antibodies was found to be 1.7%, while that among prostate cancer patients was found to be 6.3%"
    (Publication status unknown to me)
    http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8




    Other unpublished positive XMRV & PMRV studies (Not CFS or Prostate cancer)

    Detection of infectious XMRV in the peripheral blood of children
    M A Pfost et al. (WPI)
    Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
    http://regist2.virology-education.com/abstractbook/2010_8.pdf
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
    Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
    The University Of Utah Research Foundation
    (XMRV in breast cancer)
    Patent:
    http://www.wipo.int/patentscope/search/en/WO2010132886
    Info:
    http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
    XMRV proviral DNA sequences or XMRV proteins were detected in approximately 25% of 178 breast cancer samples.



    XMRV/Human DNA integration papers

    Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
    Sanggu Kim, Namshin Kim, Beihua Dong, David Boren, Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric A. Klein, Christopher Lee, Robert H. Silverman, and Samson A. Chow
    3 August 2008
    Journal Of Virology, Oct. 2008
    http://jvi.asm.org/cgi/reprint/82/20/9964

    Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma Cells
    Emily C. Knouf, Michael J. Metzger, Patrick S. Mitchell, Jason D. Arroyo, John R. Chevillet,
    Muneesh Tewari, and A. Dusty Miller*
    23 April 2009
    Journal Of Virology, July 2009,
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704771/pdf/0546-09.pdf

    Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.
    Kim S, Rusmevichientong A, Dong B, Remenyi R, Silverman RH, Chow SA
    April 20, 2010
    PloS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010255

    Deciphering the Code for Retroviral Integration Target Site Selection
    Federico Andrea Santoni, Oliver Hartley, Jeremy Luban
    November 24, 2010
    PLoS Computational Biology
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991247/pdf/pcbi.1001008.pdf

    Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.
    Garson JA, Kellam P, Towers GJ.
    25 February 2011
    Retrovirology
    http://www.retrovirology.com/content/8/1/13



    Conferences - and lists of abstracts

    CROI 2010 - 17th Conference on Retroviruses and Opportunistic Infections
    February 16-19, 2010
    XMRV related abstracts:
    http://www.cfids.org/xmrv/croi-2010.asp
    Program:
    http://zika.retroconference.org/croi-2010-pocket-program.pdf

    12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
    NCI. NIH. Office of HIV and AIDS Malignancy.
    26-27 April 2010
    http://www.capconcorp.com/meeting/12thICMAOI/agenda.asp
    http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf

    1st International Workshop on XMRV
    The abstracts of the 1st International Workshop on XMRV are published in Reviews in Antiviral Therapy & Infectious Diseases 2010_8
    7-8th September 2010
    http://www.virology-education.com/i...erial/vid/1A5D65BD-FB8B-8AE1-5E10829372D080B4
    Official Abstract Book:
    http://regist2.virology-education.com/abstractbook/2010_8.pdf
    List of Abstracts:
    http://www.mecfsforums.com/wiki/Abstracts_from_1st_International_Workshop_on_XMRV
    Oral and Poster presentations Table of results:
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    CROI 2011 - 18th Conference on Retroviruses and Opportunistic Infections
    Feb 27 - 2nd March 2011
    http://www.cfids.org/xmrv/croi-2011.asp
    http://www.retroconference.org/2011/data/files/ProgramAtAGlance_11.pdf

    American Urological Association meeting
    April 2011
    The Journal of Urology
    http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
    http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
    http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext

    NIH State Of Knowledge (SOK) Workshop - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Research
    April 7-8, 2011
    Website:
    http://orwh.od.nih.gov/CSF 2011/newsEvents.htm
    Agenda:
    http://orwh.od.nih.gov/SOK AGENDA - Final.pdf
    Video - Day 1
    http://videocast.nih.gov/launch.asp?16575
    Video - Day 2:
    http://videocast.nih.gov/launch.asp?16571

    American Urological Association meeting
    April 2011
    The Journal of Urology
    http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
    http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
    http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext

    Invest in ME Conference 2011 (No abstracts presented)
    The 6th Invest in ME International ME/CFS Conference 2011
    20th May 2011
    Conference Report by Rosamund Vallings of the Associated New Zealand ME Society:
    http://www.investinme.org/IiME Conf...onal ME Conference 2011 Conference Report.htm

    15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
    Saturday, June 4, 2011 to Wednesday, June 8, 2011
    http://forums.phoenixrising.me/show...ce on Human Retrovirology - List of Abstracts
    http://www.research1st.com/2011/06/08/15th-htlvconf/




    Investigative XMRV studies (Just a selection) (Please see conference abstracts for ongoing studies)

    An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors
    Beihua Dong, Sanggu Kim, Seunghee Hong, Jaydip Das Gupta, Krishnamurthy Malathi, Eric A. Klein, Don Ganem, Joseph L. DeRisi, Samson A. Chow, and Robert H. Silverman
    November 27, 2006
    PNAS
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776164/pdf/zpq1655.pdf

    Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
    A. L. McCormick, PhD, R. H. Brown Jr, MD, DPhil, M. E. Cudkowicz, MD, MSc, A. Al-Chalabi, PhD, FRCP and J. A. Garson, MD, PhD
    July 18, 2007.
    Neurology January 22, 2008
    http://www.neurology.org/content/70/4/278.short

    Molecular evolution of the prostate cancer susceptibility locus RNASEL: Evidence for positive selection
    Kyle Summers, and Bernard Crespi
    May 2008
    Infection, Genetics and Evolution
    http://www.sciencedirect.com/science/article/pii/S1567134808000075

    A Natural Human Retrovirus Efficiently Complements Vectors Based on Murine Leukemia Virus
    Beihua Dong, Robert H. Silverman, Eugene S. Kandel
    September 4, 2008
    PLoS ONE
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519784/pdf/pone.0003144.pdf

    Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer
    Seunghee Hong, Eric A. Klein, Jaydip Das Gupta, Kirsten Hanke, Christopher J. Weight, Carvell Nguyen, Christina Gaughan, Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
    21 April 2009
    JOURNAL OF VIROLOGY, July 2009
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf

    Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, and Robert H. Silverman
    21 April 2009
    JOURNAL OF VIROLOGY, July 2009
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704761/pdf/0268-09.pdf

    Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor
    Yuhe Yan, Qingping Liu and Christine A Kozak
    7 October 2009
    Retrovirology
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768677/pdf/1742-4690-6-87.pdf

    Androgen Stimulates Transcription and Replication of XMRV (Xenotropic Murine Leukemia Virus-Related Virus)
    Beihua Dong and Robert H. Silverman
    11 November 2009
    Journal of Virology
    http://jvi.asm.org/cgi/content/abstract/JVI.01763-09v1

    The Prostate Cancer-Associated Human Retrovirus XMRV Lacks Direct Transforming Activity but Can Induce Low Rates of Transformation in Cultured Cells
    Michael J. Metzger, Christiana J. Holguin, Ramon Mendoza, and A. Dusty Miller
    February 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/short/84/4/1874
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812358/pdf/1941-09.pdf

    Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses
    Schlecht-Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, Bouallaga I, Heidmann T.
    2010 Feb 23
    PNAS
    http://www.pnas.org/content/107/8/3782.long

    Xenotropic Murine Leukemia Virus-Related Virus Establishes an Efficient Spreading Infection and Exhibits Enhanced Transcriptional Activity in Prostate Carcinoma Cells
    Jason J. Rodriguez, and Stephen P. Goff
    March 2010
    Journal of Virology, March 2010, p. 2556-2562, Vol. 84, No. 5
    http://jvi.asm.org/cgi/content/full/84/5/2556

    Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors
    Harriet C. T. Groom, Melvyn W. Yap, Rui Pedro Galo, Stuart J. D. Neil, and Kate N. Bishop.
    16 March 2010
    PNAS , doi: 10.1073/pnas.0913650107
    http://www.pnas.org/content/107/11/5166.full

    Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
    Tobias Paprotka, Narasimhan J. Venkatachari, Chawaree Chaipan, Ryan Burdick, Krista A. Delviks-Frankenberry, Wei-Shau Hu, and Vinay K. Pathak
    24 March 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/abstract/JVI.00134-10v1

    Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
    Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N.
    2010 Mar 30
    Virology
    http://www.sciencedirect.com/science/article/pii/S0042682209008137

    Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome
    Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi
    April 1, 2010
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009948

    Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells
    Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
    21 April 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

    Prostate Cancer and Noncancerous Cells
    Sushma Bhosle, Suganthi Suppiah, Ross Molinaro, Yuying Liang, Rebecca Arnold, William Diehl, Natalia Makarova, Jerry Blackwell, John Petros, Dennis Liotta, Eric Hunter, and Hinh Ly
    21 April 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/full...ld&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

    Repeated Detection of Infectious Xenotropic Murine Virus-Related Virus (XMRV) in Human Neoplasia and Neuroimmune Diseases
    Francis Ruscetti, Vincent Lombardi, Max Pfost, Kathryn Hagen, Judy Mikovits
    26-27 April 2010
    Unpublished - Presented at the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
    http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf

    Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
    Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
    May 27, 2010
    Human Gene Therapy
    http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063

    Apobec 3G Efficiently Reduces Infectivity of the Human Exogenous Gammaretrovirus XMRV
    Kristin Stieler, Nicole Fischer
    July 23, 2010
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011738

    Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV
    Metzger MJ, Miller AD.
    August 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/full/84/15/7908?view=long&pmid=20504941

    Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies
    Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Jr
    17 August 2010
    Retrovirology 2010
    http://www.retrovirology.com/content/pdf/1742-4690-7-68.pdf

    Evolution of Functional and Sequence Variants of the Mammalian XPR1 Receptor for Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
    Yuhe Yan, Qingping Liu, Kurt Wollenberg, Carrie Martin, Alicia Buckler-White, and Christine A. Kozak
    1 September 2010
    Journal of Virology, Nov. 2010
    http://jvi.asm.org/cgi/reprint/84/22/11970

    Common Inbred Strains of the Laboratory Mouse That Are Susceptible to Infection by Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
    Surendranath Baliji, Qingping Liu,, and Christine A. Kozak
    December 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/full/84/24/12841?view=long&pmid=20943975

    Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein
    Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y.
    December 10, 2010
    Human Gene Therapy
    http://www.liebertonline.com/doi/abs/10.1089/hum.2010.063

    Severe Restriction of Xenotropic Murine Leukemia Virus-Related Virus Replication and Spread in Cultured Human Peripheral Blood Mononuclear Cells
    Chawaree Chaipan, Kari A. Dilley, Tobias Paprotka, Krista A. Delviks-Frankenberry, Narasimhan J. Venkatachari, Wei-Shau Hu, and Vinay K. Pathak*
    2011 J. Virol. doi:10.1128/JVI.00046-11
    Journal of Virology
    http://jvi.asm.org/cgi/content/abstract/JVI.00046-11v1

    Infection, viral dissemination and antibody responses of Rhesus macaques exposed to the human gammaretrovirus XMRV
    Nattawat Onlamoon, Jaydip Das Gupta, Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Jeanne Rhea, Ross J. Molinaro, Christina Gaughan, Beihua Dong, Eric A. Klein, Xiaoxing Qiu, Sushil Devare, Gerald Schochetman, John Hackett Jr., Robert H Silverman, and Franois Villinger
    2011 J. Virol. doi:10.1128/JVI.02411-10
    http://jvi.asm.org/cgi/content/abstract/JVI.02411-10v1

    NF-kB Activation Stimulates Transcription and Replication of Retrovirus XMRV in Human B-Lineage and Prostate Carcinoma Cells
    Shuhei Sakakibara, Kaori Sakakibara,, and Giovanna Tosato
    26 January 2011
    Journal of Virology, April 2011, p. 3179-3186, Vol. 85, No. 7
    http://jvi.asm.org/cgi/content/short/85/7/3179

    Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity
    Hal P. Bogerd, Fengwen Zhang, Paul D. Bieniasz and Bryan R. Cullen
    5 February 2011
    Virology
    http://www.sciencedirect.com/science/article/pii/S0042682210007270

    Purify First: Rapid expression and purification of proteins from XMRV
    William K. Gillette, Dominic Esposito, Troy E. Taylor, Ralph F. Hopkins, Rachel K. Bagni and James L. Hartley
    April 2011
    Protein Expression and Purification
    http://www.sciencedirect.com/science/article/pii/S1046592810003414

    Xmrv Infection Induces Host Genes That Regulate Inflammation And Cellular Physiology
    Michael Lee, Elona Gusho, Jaydip Das Gupta, Eric Klein, Robert Silverman
    April 2011
    The Journal of Urology
    (Unpublished abstract - presented at the American Urological Association meeting)
    http://www.jurology.com/article/S0022-5347(11)00620-3/fulltext

    Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model
    Natalia Makarova, Chunxia Zhao, Yuanyuan Zhang, Sushma Bhosle, Suganthi Suppiah, Jeanne M. Rhea, Natalia Kozyr, Rebecca S. Arnold, Hinh Ly, Ross J. Molinaro, Tristram G. Parslow, Eric Hunter, Dennis Liotta, John Petros, Jerry L. Blackwell
    April 6, 2011
    PLoS ONE
    http://www.plosone.org/article/info...onid=159E155669BA4FC9765C02D8E1CDCFD3.ambra01

    Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
    VINCENT C LOMBARDI, KATHRYN S HAGEN, KENNETH W HUNTER, JOHN W DIAMOND, JULIE SMITH-GAGEN, WEI YANG, and JUDY A. MIKOVITS
    May-June 2011
    in vivo 25: 307-314 (2011
    http://iv.iiarjournals.org/content/25/3/307.abstract?etoc

    Sexual transmission of XMRV:a potential infection route
    Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Ross Ross Molinaro Ross J. Molinaro, Nattawat Onlamoon, J. Hackett Jr., G. Schochetman, Eric A. Klein, Robert Silverman, and F. Villinger
    25 May 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/965689/

    Naturally occurring polymorphisms of the mouse gammaretrovirus receptors CAT-1 and XPR1 alter virus tropism and pathogenicity
    Christine A. Kozak
    12 July 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/975801/

    Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
    Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Peacock, Collins Karikari, Rolf A. Brekken, Victor Stastny, Boning Gao, Luc Girard, Ignacio Wistuba, Eugene Frenkel, John D. Minna and Adi F. Gazdar
    October 1, 2011
    Cancer Biology & Therapy Volume 12, Issue 7
    https://www.landesbioscience.com/journals/5/article/15955/
    https://www.landesbioscience.com/journals/cbt/ZhangCBT12-7.pdf





    XMRV & CFS Patients - Published negative studies

    Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome
    Otto Erlwein, Steve Kaye, Myra O. McClure, Jonathan Weber, Gillian Wills, David Collier, Simon Wessely, Anthony Cleare
    January 6, 2010
    PloS One
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008519

    Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
    15 February 2010
    Retrovirology
    http://www.retrovirology.com/content/7/1/10

    Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort
    Frank J M van Kuppeveld, Arjan S de Jong, Kjerstin H Lanke, Gerald W Verhaegh, Willem J G Melchers, Caroline M A Swanink, Gijs Bleijenberg, Mihai G Netea, Jochem M D Galama, Jos W M van der Meer
    25 February 2010
    BMJ
    http://www.bmj.com/content/340/bmj.c1018.full

    Absence of evidence of Xenotropic Murine Leukemia Virus-related virus infection in persons with Chronic Fatigue Syndrome and healthy controls in the United States
    William M Switzer, Hongwei Jia, Oliver Hohn, HaoQiang Zheng, Shaohua Tang, Anupama Shankar, Norbert Bannert, Graham Simmons, R Michael Hendry, Virginia R Falkenberg, William C Reeves and Walid Heneine
    1 July 2010
    Retrovirology
    http://www.retrovirology.com/content/7/1/57

    Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome
    Ping Hong, Jinming Li, Yongzhe Li
    13 September 2010
    Virology Journal
    http://www.virologyj.com/content/pdf/1743-422x-7-224.pdf

    Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
    Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM.
    2010 Nov 15
    The Journal of Infectious Diseases
    http://www.ncbi.nlm.nih.gov/pubmed/20936980

    No Evidence for XMRV in German CFS and MS Patients with Fatigue Despite the Ability of the Virus to Infect Human Blood Cells In Vitro
    Oliver Hohn, Kristin Strohschein, Alexander U. Brandt, Sandra Seeher, Sandra Klein, Reinhard Kurth, Friedemann Paul, Christian Meisel, Carmen Scheibenbogen, Norbert Bannert
    December 22, 2010
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015632

    Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses
    Brent C Satterfield, Rebecca A Garcia, Hongwei Jia, Shaohua Tang, HaoQiang Zheng, and William M Switzer
    22 February 2011
    Retrovirology
    http://www.retrovirology.com/content/8/1/12

    Investigation into the Presence of and Serological Response to XMRV in CFS Patients
    Otto Erlwein, Mark J. Robinson, Steve Kaye, Gillian Wills, Shozo Izui, Simon Wessely, Jonathan Weber, Anthony Cleare, David Collier, Myra O. McClure
    March 9, 2011
    PLoS ONE
    http://www.plosone.org/article/info...onid=D53FC24B8C7988B2019B952378A8CB06.ambra02

    No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
    Rika A Furuta, Takayuki Miyazawa, Takeki Sugiyama, Hirohiko Kuratsune, Yasuhiro Ikeda, Eiji Sato, Naoko Misawa, Yasuhito Nakatomi, Ryuta Sakuma, Kazuta Yasui, Kouzi Yamaguti, and Fumiya Hirayama
    17 March 2011
    Retrovirology
    http://www.retrovirology.com/content/8/1/20

    Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
    Steven E Schutzer MD, Megan A Rounds M, Benjamin H Natelson MD, David J Ecker PhD, Mark W Eshoo PhD
    6 April 2011
    Annals of Neurology
    http://onlinelibrary.wiley.com/doi/10.1002/ana.22389/abstract

    Absence of XMRV and other MLV-related viruses in patients with Chronic Fatigue Syndrome
    Clifford H. Shin, Lucinda Bateman, Robert Schlaberg, Ashley M. Bunker, Christopher J. Leonard, Ronald W. Hughen, Alan R. Light, Kathleen C. Light, and Ila R. Singh
    4 May 2011
    Journal of Virology
    http://jvi.asm.org/cgi/content/abstract/JVI.00693-11v1

    No Evidence of Murine-Like Gammaretroviruses in CFS Patients Previously
    Identified as XMRV-Infected

    Konstance Knox, Donald Carrigan, Graham Simmons, Fernando Teque,Yanchen Zhou, John Hackett Jr.,Xiaoxing Qiu, Ka-Cheung Luk, Gerald Schochetman, Allyn Knox, Andreas M. Kogelnik, Jay A. Levy
    31 May 2011
    Sciencexpress
    http://www.sciencemag.org/content/early/2011/05/31/science.1204963.full.pdf

    Failure to detect XMRV-specific antibodies in the plasma of CFS patients using Highly Sensitive Chemiluminescence Immunoassays
    Brendan Oakes, Xiaoxing Qiu, Susan Levine, J. Hackett Jr., and Brigitte Huber
    10 June 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/854540/

    Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome
    Jerome KR, Diem K, Huang ML, Selke S, Corey L, Buchwald D.
    Diagnostic Microbiology and Infectious Disease
    doi:10.1016/j.diagmicrobio.2011.06.003
    26 July 2011
    http://www.ncbi.nlm.nih.gov/pubmed/21795004





    Inconclusive studies & studies that add some knowledge about XMRV

    No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
    William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
    May 4, 2011
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
    ("Also, the finding of a viral strain in three prostate cancer patients that is distinct from the XMRV seen in previous studies is significant and demonstrates a broader viral diversity. This would be an expected result consistent with virus evolution during spread and persistence.")



    Overviews of XMRV Research

    A Scientific Journey Through the 2-5A/RNase L System
    Robert H. Silverman
    2007
    Cytokine Growth Factor Rev. 2007
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075094/pdf/nihms30420.pdf
    http://www.ncbi.nlm.nih.gov/pubmed/17681844

    Implications for XMRV Infections In Prostate Cancer
    Seunghee Hong
    January, 2010
    Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
    Department of Molecular Biology and Microbiology
    Molecular Virology Program
    Case Western Reserve University
    http://etd.ohiolink.edu/send-pdf.cgi/Hong Seunghee.pdf?case1251739728

    The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome
    Robert H. Silverman, Carvell Nguyen, Christopher J. Weight & Eric A. Klein
    1 June 2010
    Nature Reviews Urology
    http://www.nature.com/nrurol/journal/v7/n7/abs/nrurol.2010.77.html

    Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease
    Alice Rusmevichientong and Samson A. Chow
    August 18, 2010
    Immunological Research
    http://www.springerlink.com/content/w07qx0236q801q39/

    The mouse xenotropic gammaretroviruses and their XPR1 receptor
    Christine A Kozak
    30 November 2010
    Retrovirology 2010
    http://www.retrovirology.com/content/pdf/1742-4690-7-101.pdf

    Of mice and men: on the origin of XMRV (Article)
    Antoinette Cornelia van der Kuyl, Marion Cornelissen and Ben Berkhout
    17 January 2011
    Frontier in Virology
    http://www.frontiersin.org/virology/10.3389/fmicb.2010.00147/full

    XMRV Discovery and Prostate Cancer Related Research
    David Kang, Michael Lee, Jaydip Das Gupta, Eric A. Klein, and R. H. Silverman
    25 May 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/432837/
    http://downloads.mts.hindawi.com/MTS-Files/AV/papers/XMLV/432837.v2.pdf

    Human infection or lab artifact: will the real XMRV please stand up? (Abstract only)
    Silverman
    6 June 2011
    Presentation from the "15th International Conference on Human Retroviruses: HTLV and Related Viruses"
    http://www.retrovirology.com/content/8/S1/A241
    http://www.retrovirology.com/content/pdf/1742-4690-8-S1-A241.pdf

    Testing Strategies for Detection of Xenotropic Murine Leukemia Virus Related Virus (XMRV) Infection
    Shixing Tang and Indira K. Hewlett
    10 June 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/281425/

    Phylogeny-directed search for murine leukemia virus - like retroviruses in vertebrate genomes, and in patients suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer
    J. Blomberg, Ali Sheikholvaezin, Amal Elfaitouri, Fredrik Blomberg, Anna Sjsten, Johan Mattson Ulfstedt, Rudiger Pipkorn, Klas Kllander, Christina hrmalm, and Gran Sperber.
    22 June 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/341294/




    Reviews

    Distribution of Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection in Chronic Fatigue Syndrome and Prostate Cancer
    Judy A.Mikovits, Ying Huang, Max A.Pfost, Vincent C.Lombardi, Daniel C.Bertolette, Kathryn S.Hagen, and Francis W.Ruscetti.
    2010
    AIDS Review
    http://www.aidsreviews.com/files/2010_12_3_149-152.pdf

    Detecting Retroviral Sequences in Chronic Fatigue Syndrome
    Ila R. Singh
    3 November 2010
    Viruses 2010
    http://www.mdpi.com/1999-4915/2/11/2404/pdf

    Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples
    J. M. Coffin and Oya Cingz
    Advances in Virology
    7 July 2011
    http://www.hindawi.com/journals/av/aip/940210/




    Letters to Scientific Journals

    Mouse viruses and human disease (Letter)
    Gkikas Magiorkinis
    April 2011 doi:10.1016/S1473-3099(11)70081-0
    The Lancet Infectious Diseases
    http://www.thelancet.com/journals/l...lsca1=TLID-290311&elsca2=email&elsca3=segment

    Mouse viruses and human disease (Letter)
    Alexandre FR Stewart, D William Cameron
    April 2011 doi:10.1016/S1473-3099(11)70082-2
    The Lancet Infectious Diseases
    http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext




    Blood Related Studies & Reviews

    Xenotropic murine leukemia virusrelated virus (XMRV) and blood transfusion: report of the AABB interorganizational XMRV task force
    Harvey G. Klein, Roger Y. Dodd, F. Blaine Hollinger, Louis M. Katz, Steven Kleinman,
    K. Kimberly McCleary, Robert H. Silverman, and Susan L. Stramer
    - for the AABB Interorganizational Task Force on XMRV
    51, March 2011
    Transfusion
    http://www.aabb.org/pressroom/Documents/xmrvcommrpt011811.pdf

    The Blood Xenotropic Murine Leukemia VirusRelated Virus Scientific Research Working Group: mission, progress, and plans
    Graham Simmons, Simone A. Glynn, Jerry A. Holmberg, John M. Coffin, Indira K. Hewlett, Shyh-Ching Lo, Judy A. Mikovits, William M. Switzer, Jeffrey M. Linnen, Michael P. Busch
    - for the Blood XMRV Scientific Research Working Group
    1 March 2011
    Transfusion
    http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2011.03063.x/abstract

    XMRV, Q fever and other emerging infections: impact on management of blood safety
    R. Y. Dodd
    2011
    2011 International Society of Blood Transfusion,
    ISBT Science Series (2011) 6, 11912
    http://onlinelibrary.wiley.com/doi/10.1111/j.1751-2824.2011.01454.x/pdf

    AABB XMRV information sheet:
    http://www.aabb.org/resources/bct/eid/Documents/xmrvfactsheet.pdf

    PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!
    Philip W. Tuke, Kate I. Tettmar, Asif Tamuri, Jonathan P. Stoye, Richard S. Tedder.
    May 25, 2011
    PLoS ONE
    http://www.plosone.org/article/fetc...icleURI=info:doi/10.1371/journal.pone.0019953

    No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population
    Mark James Robinson, Philip William Tuke, Otto Erlwein, Kate I. Tettmar, Steve Kaye, Kikkeri N. Naresh, Anup Patel, Marjorie M. Walker, Takahiro Kimura, Ganesh Gopalakrishnan, Richard S. Tedder, and Myra O. McClure
    31 March 2011
    Advances in Virology doi:10.1155/2012/782353
    http://www.hindawi.com/journals/av/2011/782353/



    Patents applied for

    Compositions And Methods Relating To Xmrv-Related Diseases And Conditions
    Singh, Ila Ramnaresh; (US). Thaker, Harshwardhan Manohar; (US). Schlaberg, Robert; (US). Shin, Clifford; (US)
    The University Of Utah Research Foundation
    (XMRV in breast cancer)
    Patent:
    http://www.wipo.int/patentscope/search/en/WO2010132886
    Info:
    http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796

    Diagnosis And Treatment Of Diseases Or Disorders Associated With Xenotropic Murine Leukemia Virus-Related Virus
    MIKOVITS, Judy, A.; (US). LOMBARDI, Vincent, C.; (US). RUSCETTI, Sandra, K.; (US). RUSCETTI, Francis, W.; (US)
    WPI
    Methods of detecting XMRV, and diagnosing XMRV-related illnesses etc.
    http://www.wipo.int/patentscope/sea...lter=&sortOption=&queryString=&tab=PCT Biblio

    Detection Of Xenotropic Murine Leukemia Virus
    Mikovits; Judy A.; (Reno, NV) ; Lombardi; Vincent; (Reno, NV) ; Ruscetti; Sandra; (New Market, MD) ; Ruscetti; Francis; (New Market, MD) ; Silverman; Robert; (Beachwood, OH)
    WPI
    "Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed."
    June 23, 2011
    http://www.freepatentsonline.com/y2011/0151431.html
    http://appft.uspto.gov/netacgi/nph-...ND&d=PG01&s1=mikovits&OS=mikovits&RS=mikovits





    Positive XMRV Prostate Cancer studies

    Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
    Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
    31st March 2006
    http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn
    (XMRV was first discovered in 2006 in prostate cancer patients. This is the original XMRV paper)
    (Results: XMRV in QQ genotype = 40%, XMRV in RQ + RR genotypes = 1.5%, Healthy controls = not tested.)

    XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberga, Daniel J. Choeb, Kristy R. Browna, Harshwardhan M. Thakerb and Ila R. Singh,
    September 8, 2009
    PNAS
    http://www.pnas.org/content/early/2009/09/04/0906922106.abstract
    (Results: XMRV in prostate cancer tissue by IHC = 23%. XMRV in benign tissue controls by IHC = 4%)

    XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH.
    Arnold RS, Makarova NV, Osunkoya AO, Suppiah S, Scott TA, Johnson NA, Bhosle SM, Liotta D, Hunter E, Marshall FF, Ly H, Molinaro RJ, Blackwell JL, Petros JA.
    April 2010
    Urology
    http://www.goldjournal.net/article/S0090-4295(10)00117-2/abstract
    (Results: XMRV in QQ genotype tested for XMRV antibodies = 40%, XMRV in either RQ or RR genotype = 15%, Healthy controls = not tested.)

    Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions
    Danielson BP, Ayala GE, Kimata JT.
    Nov 2010.
    The Journal of Infection Diseases
    http://www.ncbi.nlm.nih.gov/pubmed/20936978
    (Results: XMRV detected in 22% of prostate cancer patients, in normal and tumour prostate tissue, independent of genotype. Healthy controls not tested.)




    Unpublished Positive XMRV Prostate Cancer studies

    Xenotropic Murine Leukemia Virus Related Virus (Xmrv) Is Present In Malignant Prostate Tissue But Does Not Affect Pathological Or Clinical Outcome
    Chad Ritch, Ruslan Korets, Mireia Castillo-Martin, Josep Domingo-Domenech, Mitchell Benson, Carlos Cordon-Cardo
    April 2011
    The Journal of Urology (Abstract presented at the American Urological Association meeting)
    http://www.jurology.com/article/S0022-5347(11)01618-1/fulltext
    Immunofluorescence: XMRV detected in 33/65 (51%) of malignant samples, and in only 5/42 benign samples (12%).
    PCR: XMRV detected 14/65 (21%) of prostate cancer samples, and 2/42 (5%) in benign tissue
    Combined PCR and IF: XMRV was detected in at least 17% of malignant samples and rarely found in benign tissue.

    A Preliminary Screening Of Xenotropic Murine Leukemia Virus-Related Virus In Japanese Prostate Cancer Patients
    Tsukasa Igawa, Yoshinao Kubo, Katsura Kakoki, Naoki Yamamoto, Hideki Sakai
    April 2011
    The Journal of Urology (Abstract presented at the American Urological Association meeting)
    http://www.jurology.com/article/S0022-5347(11)01208-0/fulltext
    (MLV sequences were detected in four out of sixty one patients (6.7%))




    Inconclusive & No Association XMRV Prostate Cancer studies (Some XMRV detected)

    Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
    Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T.
    2008 Nov (published online 29 September 2008)
    J Clin Virol. 2008 Nov;43(3):277-83. Epub 2008 Sep 27.
    http://www.journalofclinicalvirology.com/article/S1386-6532(08)00301-6/abstract
    (Results: XMRV in prostate cancer = 0.95% XMRV in healthy controls = 1.4%)

    Identification of viral infections in the prostate and evaluation of their association with cancer
    Martinez-Fierro ML, Leach RJ, Gomez-Guerra LS, Garza-Guajardo R, Johnson-Pais T, Beuten J, Morales-Rodriguez IB, Hernandez-Ordoez MA, Calderon-Cardenas G, Ortiz-Lopez R, Rivas-Estilla AM, Ancer-Rodriguez J, Rojas-Martinez A.
    24 June 2010
    BMC Cancer
    http://www.biomedcentral.com/1471-2407/10/326/
    (Results: XMRV in prostate cancer tissue=0. XMRV in normal controls = 1.3%)

    Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients.
    Verhaegh GW, de Jong AS, Smit FP, Jannink SA, Melchers WJ, Schalken JA.
    March 2011
    http://www.ncbi.nlm.nih.gov/pubmed/20878949
    (Results: XMRV sequences were detected in 3 out of 74 (i.e., 4%) PrCa specimens.)

    No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
    Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F.
    17th March 2011
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065418/

    No evidence of XMRV in prostate cancer cohorts in the Midwestern United States
    Toshie Sakuma, Stphane Hu , Karen A Squillace , Jason M Tonne , Patrick R Blackburn , Seiga Ohmine , Tayaramma Thatava , Greg J Towers and Yasuhiro Ikeda.
    29 March 2011
    Retrovirology 2011, 8:23doi:10.1186/1742-4690-8-23
    http://www.retrovirology.com/content/8/1/23

    No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
    William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
    May 4, 2011
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
    (Results: XMRV in prostate cancer = 1.9%)












    continued in next post.....
  2. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    The list is too long for a single post, so it continues here...

    _______________________________


    ...cont...


    Negative XMRV Prostate Cancer Studies (No XMRV detected)

    Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients
    Oliver Hohn, Hans Krause, Pia Barbarotto, Lars Niederstadt, Nadine Beimforde, Joachim Denner, Kurt Miller, Reinhard Kurth and Norbert Bannert
    16 October 2009
    Retrovirology
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770519/pdf/1742-4690-6-92.pdf

    No difference in antibody titers against xenotropic MLV related virus in prostate cancer cases and cancer-free controls.
    Sabunciyan S, Mandelberg N, Rabkin CS, Yolken R, Viscidi R.
    31 January 2011
    Molecular and Cellular Probes - doi:10.1016/j.mcp.2011.01.005
    http://www.sciencedirect.com/science/article/pii/S0890850811000065

    No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan
    Rika A Furuta, Takayuki Miyazawa, Takeki Sugiyama, Hirohiko Kuratsune, Yasuhiro Ikeda, Eiji Sato, Naoko Misawa, Yasuhito Nakatomi, Ryuta Sakuma, Kazuta Yasui, Kouzi Yamaguti, and Fumiya Hirayama
    17 March 2011
    Retrovirology
    http://www.retrovirology.com/content/8/1/20

    No evidence of XMRV in prostate cancer cohorts in the Midwestern United States
    Toshie Sakuma, Stphane Hu , Karen A Squillace , Jason M Tonne , Patrick R Blackburn , Seiga Ohmine , Tayaramma Thatava , Greg J Towers and Yasuhiro Ikeda.
    29 March 2011
    Retrovirology 2011, 8:23doi:10.1186/1742-4690-8-23
    http://www.retrovirology.com/content/8/1/23

    No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population
    Mark James Robinson, Philip William Tuke, Otto Erlwein, Kate I. Tettmar, Steve Kaye, Kikkeri N. Naresh, Anup Patel, Marjorie M. Walker, Takahiro Kimura, Ganesh Gopalakrishnan, Richard S. Tedder, and Myra O. McClure
    31 March 2011
    Advances in Virology doi:10.1155/2012/782353
    http://www.hindawi.com/journals/av/2011/782353/

    No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
    William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
    May 4, 2011
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0




    Negative XMRV studies other

    No Evidence of XMRV or Related Retroviruses in a London HIV-1-Positive Patient Cohort
    Eleanor R. Gray, Jeremy A. Garson, Judith Breuer, Simon Edwards, Paul Kellam1, Deenan Pillay, Greg J. Towers
    March 23, 2011
    PLoS ONE
    http://www.plosone.org/article/info...osone/PLoSONE (PLoS ONE Alerts: New Articles)

    Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients
    F. Maggi1, D. Focosi, L. Lanini, S. Sbranti, P. Mazzetti, L. Macera, S. Davini, M. De Donno, M. L. Mariotti, G. Antonelli, F. Scatena, M. Pistello.
    14 June 2011
    Clinical Microbiology and Infection
    http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2011.03580.x/abstract

    PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!
    Philip W. Tuke, Kate I. Tettmar, Asif Tamuri, Jonathan P. Stoye, Richard S. Tedder.
    May 25, 2011
    PLoS ONE
    http://www.plosone.org/article/fetc...icleURI=info:doi/10.1371/journal.pone.0019953

    No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population
    Mark James Robinson, Philip William Tuke, Otto Erlwein, Kate I. Tettmar, Steve Kaye, Kikkeri N. Naresh, Anup Patel, Marjorie M. Walker, Takahiro Kimura, Ganesh Gopalakrishnan, Richard S. Tedder, and Myra O. McClure
    31 March 2011
    Advances in Virology doi:10.1155/2012/782353
    http://www.hindawi.com/journals/av/2011/782353/





    Contamination studies and theories

    Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease
    Ccile Voisset, Robin A. Weiss, and David J. Griffiths
    March 2008
    Microbiology and Molecular Biology Reviews
    http://mmbr.asm.org/cgi/content/full/72/1/157

    A cautionary tale of virus and disease (opinion)
    Robin A Weiss
    27 September 2010
    BMC Biology
    http://www.biomedcentral.com/1741-7007/8/124

    Disease-associated XMRV sequences are consistent with laboratory contamination
    Stphane Hu, Eleanor R Gray, Astrid Gall, Aris Katzourakis, Choon Ping Tan, Charlotte J Houldcroft, Stuart McLaren, Deenan Pillay, Andrew Futreal, Jeremy A Garson, Oliver G Pybus, Paul Kellam, Greg J Towers
    20 December 2010
    Retrovirology
    http://www.retrovirology.com/content/pdf/1742-4690-7-111.pdf

    An Endogenous Murine Leukemia Viral Genome Contaminant in a Commercial RT-PCR Kit is Amplified Using Standard Primers for XMRV
    Eiji Sato, Rika A Furuta, Takayuki Miyazawa
    20 December 2010
    Retrovirology
    http://www.retrovirology.com/content/pdf/1742-4690-7-110.pdf

    Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences
    Brendan Oakes, Albert K Tai, Oya Cingz, Madeleine H Henefield, Susan Levine, John M Coffin, Brigitte T Huber
    20 December 2010
    Retrovirology
    http://www.retrovirology.com/content/pdf/1742-4690-7-109.pdf

    Mouse DNA contamination in human tissue tested for XMRV
    Mark J Robinson, Otto W Erlwein, Steve Kaye, Jonathan Weber, Oya Cingoz, Anup Patel, Marjorie M Walker, Wun-Jae Kim, Mongkol Uiprasertkul, John M Coffin, Myra O McClure
    20 December 2010
    Retrovirology
    http://www.retrovirology.com/content/pdf/1742-4690-7-108.pdf

    Contamination of clinical specimens with MLVencoding nucleic acids: implications for XMRV and other candidate human retroviruses
    Robert A Smith
    20 December 2010
    Viewpoints,
    Retrovirology 2010
    http://www.retrovirology.com/content/pdf/1742-4690-7-112.pdf

    Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.
    Garson JA, Kellam P, Towers GJ.
    25 February 2011
    Retrovirology
    http://www.retrovirology.com/content/8/1/13

    PCR Master Mixes Harbour Murine DNA Sequences. Caveat Emptor!
    Philip W. Tuke, Kate I. Tettmar, Asif Tamuri, Jonathan P. Stoye, Richard S. Tedder.
    May 25, 2011
    PLoS ONE
    http://www.plosone.org/article/fetc...icleURI=info:doi/10.1371/journal.pone.0019953

    Recombinant Origin of the Retrovirus XMRV
    Tobias Paprotka, Krista A. Delviks-Frankenberry, Oya Cingz, Anthony Martinez, Hsing-Jien Kung, Clifford G. Tepper, Wei-Shau Hu, Matthew J. Fivash Jr., John M. Coffin, Vinay K. Pathak
    31 May 2011
    Ssciencexpress
    http://www.sciencemag.org/content/early/2011/05/31/science.1205292.full.pdf
    Supporting material:
    http://www.sciencemag.org/content/suppl/2011/05/31/science.1205292.DC1/1205292s.pdf

    Xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer cells likely represents a laboratory artifact
    Jiawen Yang, Partho Battacharya, Ruchi Singhal, Eugene S. Kandel
    June 2, 2011
    Impact Journals - Oncotarget
    http://impactjournals.com/oncotarge...et&page=article&op=view&path[]=287&path[]=438

    Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell Lines
    Karen Sandell Sfanos, Amanda L. Aloia, Jessica L. Hicks, David M. Esopi, Jared P. Steranka, Wei Shao, Silvia Sanchez-Martinez, Srinivasan Yegnasubramanian, Kathleen H. Burns, Alan Rein, Angelo M. De Marzo.
    June 17, 2011
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020874

    The left half of XMRV is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells
    Ramon Mendoza, Andrew E. Vaughan, and A. Dusty Miller
    22 June 2011
    Journal of Virology J. Virol. doi:10.1128/JVI.05137-11
    http://jvi.asm.org/cgi/content/abstract/JVI.05137-11v1?forumid=331851

    Endogenous Murine Leukemia Viruses: Relationship to XMRV and MLVs Detected in Human DNA Samples
    J. M. Coffin and Oya Cingz
    7 July 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/940210/

    Phylogenetic analysis of MLV sequences from longitudinally sampled Chronic Fatigue Syndrome patients suggests PCR contamination rather than viral evolution
    Aris Katzourakis, Stphane Hu, Paul Kellam, and Greg J. Towers.
    Journal of Virology
    17 August 2011
    J. Virol. doi:10.1128/JVI.00827-11
    http://jvi.asm.org/cgi/content/abst...id=1&usestrictdates=yes&resourcetype=HWCIT&ct

    Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
    Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Peacock, Collins Karikari, Rolf A. Brekken, Victor Stastny, Boning Gao, Luc Girard, Ignacio Wistuba, Eugene Frenkel, John D. Minna and Adi F. Gazdar
    October 1, 2011
    Cancer Biology & Therapy Volume 12, Issue 7
    https://www.landesbioscience.com/journals/5/article/15955/
    https://www.landesbioscience.com/journals/cbt/ZhangCBT12-7.pdf




    Papers that provide evidence against contamination theories

    This list has only just been started - more to come

    No Association of Xenotropic Murine Leukemia Virus-Related Viruses with Prostate Cancer
    William M. Switzer, Hongwei Jia, HaoQiang Zheng, Shaohua Tang, Walid Heneine
    May 4, 2011
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019065#abstract0
    "Also, the finding of a viral strain in three prostate cancer patients that is distinct from the XMRV seen in previous studies is significant and demonstrates a broader viral diversity. This would be an expected result consistent with virus evolution during spread and persistence."

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    Mattia C F Prosperi , William M Switzer, Walid Heneine and Marco Salemi
    6 June 2011
    Unpublished abstract presented to the '15th International Conference on Human Retroviruses: HTLV and Related Viruses'
    Retrovirology 2011, 8(Suppl 1):A235doi:10.1186/1742-4690-8-S1-A235
    http://www.retrovirology.com/content/8/S1/A235
    Conclusion:
    "Given the evidence of inter-tropic recombination in MuLV, detection and classification of recombination in XMRV using different MuLV tropism prototypes should be interpreted with caution ... These results suggest that identification of parental strains of the potential recombinants is difficult and that recombination in the highly genetically related MuLV have been occurring for some time."


    Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts
    Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Peacock, Collins Karikari, Rolf A. Brekken, Victor Stastny, Boning Gao, Luc Girard, Ignacio Wistuba, Eugene Frenkel, John D. Minna and Adi F. Gazdar
    October 1, 2011
    Cancer Biology & Therapy Volume 12, Issue 7
    https://www.landesbioscience.com/journals/5/article/15955/
    https://www.landesbioscience.com/journals/cbt/ZhangCBT12-7.pdf




    MLV Recombination Theory Studies

    Recombinant Origin of the Retrovirus XMRV
    Tobias Paprotka, Krista A. Delviks-Frankenberry, Oya Cingz, Anthony Martinez, Hsing-Jien Kung, Clifford G. Tepper, Wei-Shau Hu, Matthew J. Fivash Jr., John M. Coffin, Vinay K. Pathak
    31 May 2011
    Sciencexpress
    http://www.sciencemag.org/content/early/2011/05/31/science.1205292.full.pdf
    Supporting material:
    http://www.sciencemag.org/content/suppl/2011/05/31/science.1205292.DC1/1205292s.pdf

    The left half of XMRV is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells
    Ramon Mendoza, Andrew E. Vaughan, and A. Dusty Miller
    22 June 2011
    Journal of Virology J. Virol. doi:10.1128/JVI.05137-11
    http://jvi.asm.org/cgi/content/abstract/JVI.05137-11v1?forumid=331851

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    Mattia C F Prosperi , William M Switzer, Walid Heneine and Marco Salemi
    6 June 2011
    Unpublished abstract presented to the '15th International Conference on Human Retroviruses: HTLV and Related Viruses'
    Retrovirology 2011, 8(Suppl 1):A235doi:10.1186/1742-4690-8-S1-A235
    http://www.retrovirology.com/content/8/S1/A235




    Other negative studies (Not CFS or Prostate cancer)

    Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.
    Kunstman KJ, Bhattacharya T, Flaherty J, Phair JP, Wolinsky SM.
    17 July 2010
    AIDS
    http://www.ncbi.nlm.nih.gov/pubmed/20597166

    No evidence for XMRV association in pediatric idiopathic diseases in France
    Eric Jeziorski, Vincent Foulongne, Catherine Ludwig, Djamel Louhaem, Gilles Chiocchia, Michel Segondy, Michel Rodire, Marc Sitbon, and Valrie Courgnaud
    2 August 2010
    Retrovirology
    http://www.retrovirology.com/content/7/1/63

    Lack of Detection of XMRV in Seminal Plasma from HIV-1 Infected Men in The Netherlands
    Marion Cornelissen, Fokla Zorgdrager, Petra Blom, Suzanne Jurriaans, Sjoerd Repping, Elisabeth van Leeuwen, Margreet Bakker, Ben Berkhout, Antoinette C. van der Kuyl
    August 10, 2010
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012040

    PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism
    Brent C Satterfield (Cooperative Diagnostics), Rebecca A Garcia, Fiorella Gurrieri and Charles E Schwartz
    14 October 2010
    Molecular Autism 2010, 1:14 doi:10.1186/2040-2392-1-14
    http://www.molecularautism.com/content/1/1/14

    Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections
    Barnes E, Flanagan P, Brown A, Robinson N, Brown H, McClure M, Oxenius A, Collier J, Weber J, Gnthard HF, Hirschel B, Fidler S, Phillips R, Frater J.
    2010 Nov 15
    Journal of Infectious Diseases
    http://www.ncbi.nlm.nih.gov/pubmed/20936982

    Lack of Infection with XMRV or Other MLV-Related Viruses in Blood, Post-Mortem Brains and Paternal Gametes of Autistic Individuals
    Carla Lintas1,2, Francesco Guidi3, Barbara Manzi4, Antonio Mancini5, Paolo Curatolo4, Antonio M. Persico1,2
    February 23, 2011
    PLoS ONE 6(2): e16609. doi:10.1371/journal.pone.0016609
    http://www.plosone.org/article/info...onid=6F4016946515F29A53051C40E29FE56E.ambra02

    No Evidence of XMRV or Related Retroviruses in a London HIV-1-Positive Patient Cohort
    Eleanor R. Gray, Jeremy A. Garson, Judith Breuer, Simon Edwards, Paul Kellam, Deenan Pillay, Greg J. Towers
    March 23, 2011
    PLoS ONE 6(3): e18096. doi:10.1371/journal.pone.0018096
    http://www.plosone.org/article/info...osone/PLoSONE (PLoS ONE Alerts: New Articles)

    Xenotropic Murine Leukemia Virus-Related Virus (XMRV) in Patients with Systemic Lupus Erythematosus.
    Balada E, Castro-Marrero J, Felip L, Vilardell-Tarrs M, Ordi-Ros J.
    April 21, 2011
    Journal Of Clinical Immunology
    http://www.springerlink.com/content/h711880401653u48/




    Science Journal editorial Editorial Expression of Concern

    Editorial Expression of Concern
    Bruce Alberts
    31 May 2011
    http://www.sciencemag.org/content/early/2011/05/31/science.1208542.full.pdf

    Dr. Mikovits' response to the Editorial Expression of Concern
    http://files.me.com/jdj88/keednw

    Annette Whittemore's response to the Editorial Expression of Concern
    http://files.me.com/jdj88/tnmi0f

    Response from the WPI's Clinical Advisory Board to the Editorial Expression of Concern
    http://files.me.com/jdj88/hok3p2

    A Comparison of Methods for the Detection and Association of XMRV in Chronic Fatigue Syndrome - Replication Analysis.
    WPI
    June 2011
    http://files.me.com/jdj88/tzgfod
    http://treatingxmrv.blogspot.com/2011/06/comparison-of-methods-for-detection-and.html




    Historical research looking at MLV-related viruses associated with human disease

    Viral-Related RNA in Hodgkins' Disease and Other Human Lymphomas
    R. Hehlmann, D. Kufe, and S. Spiegelman
    July 1972
    Proc Natl Acad Sci U S A. 1972 July; 69(7): 17271731.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC426788/?tool=pubmed

    RNA in Human Leukemic Cells Related to the RNA of a Mouse Leukemia Virus
    R. Hehlmann, D. Kufe, and S. Spiegelman
    Feb 1972
    Proc Natl Acad Sci U S A. 1972 February; 69(2): 435439
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC426474/?tool=pubmed

    Human sarcomas contain RNA related to the RNA of a mouse leukemia virus.
    Kufe D, Hehlmann R, Spiegelman S.
    Jan 1972
    Science. 1972 Jan 14;175(18):182-5.
    http://www.ncbi.nlm.nih.gov/pubmed/4332759

    Burkitt's Tumors Contain Particles Encapsulating RNA-Instructed DNA Polymerase and High Molecular Weight Virus-Related RNA
    D. Kufe,* I. T. Magrath, J. L. Ziegler, and S. Spiegelman
    March 1973
    Proc Natl Acad Sci U S A. 1973 March; 70(3): 737741.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC433347/?tool=pubmed

    Sequences Present in Both Human Leukemic Cell Nuclear DNA and Rauscher Leukemia Virus
    William G. Baxt
    July 1974
    Proc Natl Acad Sci U S A. 1974 July; 71(7): 28532857.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC388570/?tool=pubmed

    Rauscher-leukemia-virus-related sequences in human DNA: presence in some tissues of some patients with hemotopoietic neoplasias and absence in DNA from other tissues.
    G S Aulakh and R C Gallo
    Jan 1977
    Proc Natl Acad Sci U S A. 1977 January; 74(1): 353357.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC393258/?tool=pubmed

    Retroviral sequences related to human T-lymphotropic virus type II in patients with chronic fatigue immune dysfunction syndrome
    Elaine Defreitas, Brendan Hilliard, Paul R. Cheney, David S. Bell, Edward Kiggundu, Diane Sankey, Zofia Wroblewska, Maria Palladino, John P. Woodward, And Hilary Koprowski
    November 13, 1990
    Medical Sciences April 1991
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC51352/pdf/pnas01057-0319.pdf

    Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992
    Centers for Disease Control and Prevention (CDC).
    1993 Mar
    http://www.ncbi.nlm.nih.gov/pubmed/8446093
    http://www.cdc.gov/mmwr/preview/mmwrhtml/00019881.htm

    Detection of mammary tumor virus env gene-like sequences in human breast cancer.
    Wang Y, Holland JF, Bleiweiss IJ, Melana S, Liu X, Pelisson I, Cantarella A, Stellrecht K, Mani S, Pogo BG.
    1995 Nov 15
    http://cancerres.aacrjournals.org/content/55/22/5173.long

    Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus.
    Stewart TH, Sage RD, Stewart AF, Cameron DW.
    17 December 1999
    http://www.nature.com/bjc/journal/v82/n2/full/6690941a.html

    Mouse mammary tumor virus-like ENV gene sequences in human breast tumors and in a lymphoma of a breast cancer patient.
    Etkind P, Du J, Khan A, Pillitteri J, Wiernik PH.
    2000 April
    http://clincancerres.aacrjournals.org/content/6/4/1273.long

    High prevalence of an IgG response against murine leukemia virus (MLV) in patients with psoriasis
    Mols JP, Hadi JC, Guilhou JJ.
    Aug 2003
    Virus Research
    http://www.sciencedirect.com/science/article/pii/S0168170203001370



    Antiretroviral Research

    Xenotropic murine leukemia virus-related virus is susceptible to AZT
    Sakuma R, Sakuma T, Ohmine S, Silverman RH, Ikeda Y.
    2010 Feb 5
    Virology
    http://www.ncbi.nlm.nih.gov/pubmed/19959199

    Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
    Tobias Paprotka, Narasimhan J. Venkatachari, Chawaree Chaipan, Ryan Burdick, Krista A. Delviks-Frankenberry, Wei-Shau Hu, and Vinay K. Pathak
    24 March 2010
    Journal of Virology
    http://jvi.asm.org/cgi/content/abstract/JVI.00134-10v1

    Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome
    Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi
    April 1, 2010
    PLoS ONE
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009948

    Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith, Geoffrey S Gottlieb, A Dusty Miller
    31 August 2010
    Retrovirology 2010
    http://www.retrovirology.com/content/pdf/1742-4690-7-70.pdf




    Related/Relevant HIV Research

    Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis
    Prof Andrew E Grulich PhD, Marina T van Leeuwen MPH, Michael O Falster BPsych[Hons], Claire M Vajdic PhD
    7 July 2007
    http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61050-2/fulltext

    Spectrum of cancer risk late after AIDS onset in the United States.
    Simard EP, Pfeiffer RM, Engels EA.
    2010 Aug 9
    http://www.ncbi.nlm.nih.gov/pubmed/20696958

    Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients
    Krista Delviks-Frankenberry, Chawaree Chaipan, Rachel Bagni, Kathleen Wyvill, R. Yarchoan, and Vinay Pathak
    11 July 2011
    Advances in Virology
    http://www.hindawi.com/journals/av/aip/797820/




    Related/Relevant HTLV Research

    Low Degree of Human T-Cell Leukemia/Lymphoma Virus Type I Genetic Drift In Vivo as a Means of Monitoring Viral Transmission and Movement of Ancient Human Populations
    Antoine Gessain, Robert C. Gallo, and Genoveffa Franchini
    21 October 1991
    http://jvi.asm.org/cgi/reprint/66/4/2288

    Complete Nucleotide Sequence of a Highly Divergent Human T-Cell Leukemia (Lymphotropic) Virus Type I (HTLV-I) Variant from Melanesia: Genetic and Phylogenetic Relationship to HTLV-I Strains from Other Geographical Regions
    Antoine Gessain, Enzo Boeri, Richard Yanagihara, Robert C. Gallo, and Genoveffa Franchini
    12 November 1992
    http://jvi.asm.org/cgi/reprint/67/2/1015.pdf

    The Low Evolutionary Rate of Human T-Cell Lymphotropic Virus Type-1 Confirmed by Analysis of Vertical Transmission Chains
    S. Van Dooren, O. G. Pybus, M. Salemi, H.-F. Liu, P. Goubau, C. Remondegui, A. Talarmin, E. Gotuzzo, L. C. J. Alcantara, B. Galvo-Castro, and A.-M. Vandamme
    January 22, 2004
    Molecular Biology and Evolution
    http://mbe.oxfordjournals.org/content/21/3/603.full




    Other research related to XMRV/CFS

    Avian leukemias and lymphomas : Interplay between retroviruses and herpesviruses
    Robinson D, Liu JL, Jones D, Brunovskis P, Qian Z, Isfort R, Tillotson JK, Lee L, Witter R, Salter D, Crittenden L, Hughes S, Kung HJ.
    1997 Apr
    Leukemia.
    http://www.ncbi.nlm.nih.gov/pubmed/9209335

    Precise identification of endogenous proviruses of NFS/N mice participating in recombination with moloney ecotropic murine leukemia virus (MuLV) to generate polytropic MuLVs.
    Alamgir AS, Owens N, Lavignon M, Malik F, Evans LH.
    April 2005
    Journal of Virology
    http://www.ncbi.nlm.nih.gov/pubmed/15795252

    RNase L, a crucial mediator of innate immunity and other cell functions
    Catherine Bisbal and Tamim Salehzada
    15 Octobre 2008
    Medecine/Sciences
    http://www.ncbi.nlm.nih.gov/pubmed/18950583
    http://www.medecinesciences.org/ind...doi&doi=10.1051/medsci/20082410859&Itemid=129

    Unintended spread of a biosafety level 2 recombinant retrovirus
    Alexander Stang, Elisabeth Petrasch-Parwez, Sabine Brandt, Rolf Dermietzel, Helmut E Meyer, Kai Sthler, Sven-T Liffers,
    Klaus berl, and Thomas Grunwald
    22 September 2009
    Retrovirology
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760500/pdf/1742-4690-6-86.pdf

    Endogenous retroviruses as potential hazards for vaccines
    Takayuki Miyazawa
    12 March 2010
    Biologicals
    http://www.ecs.umass.edu/~mettu/ece597m/papers/Leung/sdarticle-1.pdf





    XMRV Sequences in genbank (This section is a not completed its not a full list)

    Some information:
    http://forums.phoenixrising.me/showthread.php?11714-New-WPI-and-CDC-XMRV-sequences-in-genbank



    Other information

    A Comparison of Methods for the Detection and Association of XMRV in Chronic Fatigue Syndrome
    WPI
    http://files.me.com/jdj88/tzgfod
    http://treatingxmrv.blogspot.com/2011/06/comparison-of-methods-for-detection-and.html

    Sandra K. Ruscetti website:
    http://ccr.cancer.gov/staff/staff.asp?profileid=5518

    Microbe Hunting
    W. Ian Lipkin
    Sept. 2010
    Microbiology And Molecular Biology Reviews
    http://cii.columbia.edu/news/documents/MicrobeHunting_MMBR.pdf

    Trans-NIH ME/CFS Research Working Group Website
    NIH Website
    http://orwh.od.nih.gov/CSF 2011/CFS_home.htm

    Primer set list for each XMRV study:
    http://www.mecfsforums.com/wiki/Primer_set_list_for_each_XMRV_study

    Investigating Viruses in Cells Used to Make Vaccines; and Evaluating the Potential Threat Posed by Transmission of Viruses to Humans
    Arifa S. Khan, PhD
    FDA Website - ongoing research project
    http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm


    Comparison Tables XMRV research studies

    Prevalence Studies on XMRV and MLV-related Virus Infection in Human Diseases and General Populations
    FDA
    3rd March 2010
    http://www.fda.gov/downloads/Adviso.../BloodProductsAdvisoryCommittee/UCM234925.pdf

    Studies of the Prevalence of Evidence of Murine Leukemia Virus(es) in Patients with CFS
    1st International XMRV Workshop: Oral and Poster Presentations

    CFIDS Association of America
    7-8th September 2010
    http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf

    Published Studies on XMRV and MLRV Findings in Human Diseases and the General Population
    (Table adapted from Gubernot D and Hewlett I, FDA Blood Products Advisory Committee Meeting, December 2010)
    AABB
    December 2010
    http://www.aabb.org/resources/bct/eid/Documents/xmrvtable.pdf

    Comparison of Published Studies of XMRV and Sequences of Other Murine Leukemia Viruses in Patients with CFS (ME/CFS)
    CFIDS Association of America
    May 4, 2011 (updated as of May 4, 2011)
    http://www.cfids.org/xmrv/data-comparison-082410.pdf

    A Comparison of Methods for the Detection and Association of XMRV in Chronic Fatigue Syndrome - Replication Analysis.
    WPI
    June 2011
    http://files.me.com/jdj88/tzgfod
    http://treatingxmrv.blogspot.com/2011/06/comparison-of-methods-for-detection-and.html





    Conference Abstracts (A small selection of abstracts)

    Detection of XMRV sequences in EBV-transformed B cell lines
    Pilot study by J Blanco et al:
    "Envelope amplification yielded positive bands in 4 out of 21 individuals tested, 3 CFS affected individuals and 1 healthy donor.However, gag amplification yielded only 3 positive samples (1 CFS affected individual, 1 healthy donor and one HIV+ patient).In contrast, Real-time PCR of Pol fragment detected 7 positives samples in 14 individuals tested (4 SFC , 2 donors and 1 HIV+ individuals)."
    http://regist2.virology-education.com/abstractbook/2010_8.pdf

    Organ and Cell Lineage Dissemination of XMRV in Rhesus Macaques during Acute and Chronic Infection
    Prachi Sharma, S Supplah, R Molinaro, K Rogers, J Das Gupta, R Silverman, J Hackett, Jr., S Devare, G Schochetman and F Villanger
    Presented at the The 17th Conference on Retroviruses and Opportunistic Infections
    (CROI 2010)
    Feb 2010
    http://www.cfids.org/xmrv/croi-2010.asp

    Repeated Detection of Infectious Xenotropic Murine Virus-Related Virus (XMRV) in Human Neoplasia and Neuroimmune Diseases
    Francis Ruscetti, Vincent Lombardi, Max Pfost, Kathryn Hagen, Judy Mikovits
    26-27 April 2010
    Unpublished - Presented at the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)
    http://oham.cancer.gov/objects/pdf/2010ICMAOI_Program_Book.pdf

    Is the mechanism of systemic immune activation in XMRV positive CFS patients similar to that observed in HIV?
    Kenny De Meirlier
    Unpublished poster presentation from the 1st International Workshop on XMRV, 7-8th September 2010
    http://esme-eu.com/xmrv/is-the-mech...r-to-that-observed-in-hiv-article419-191.html
    http://esme-eu.com/getfile.php/Files/de Meirleir, K., poster for XMRV workshop[1](1).pdf
    http://regist2.virology-education.com/abstractbook/2010_8.pdf

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    Mattia C F Prosperi , William M Switzer, Walid Heneine and Marco Salemi
    6 June 2011
    Unpublished abstract presented to the '15th International Conference on Human Retroviruses: HTLV and Related Viruses'
    Retrovirology 2011, 8(Suppl 1):A235doi:10.1186/1742-4690-8-S1-A235
    http://www.retrovirology.com/content/8/S1/A235

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    Mattia C F Prosperi , William M Switzer, Walid Heneine and Marco Salemi
    6 June 2011
    Unpublished abstract presented to the '15th International Conference on Human Retroviruses: HTLV and Related Viruses'
    Retrovirology 2011, 8(Suppl 1):A235doi:10.1186/1742-4690-8-S1-A235
    http://www.retrovirology.com/content/8/S1/A235
    Conclusion:
    "Given the evidence of inter-tropic recombination in MuLV, detection and classification of recombination in XMRV using different MuLV tropism prototypes should be interpreted with caution ... These results suggest that identification of parental strains of the potential recombinants is difficult and that recombination in the highly genetically related MuLV have been occurring for some time."





    Student Theses relating to XMRV

    Implications for XMRV Infections In Prostate Cancer
    Seunghee Hong
    January, 2010
    Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
    Department of Molecular Biology and Microbiology
    Molecular Virology Program
    Case Western Reserve University
    http://etd.ohiolink.edu/send-pdf.cgi/Hong Seunghee.pdf?case1251739728

    Evaluating XMRV As An Indicator Of Prostate Cancer Risk
    Maria Barton
    August, 2011
    Thesis
    A thesis submitted to Kent State University in collaboration with the Lerner Research Institute, Cleveland Clinic
    in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE
    (Thesis approved by Dr. R.H. Silverman, Dr. R.V. Dorman, Dr. John Stalvey.)
    http://etd.ohiolink.edu/view.cgi?acc_num=kent1309619878




    Other resources

    CFIDS Association of America (CAA)
    XMRV Resources Listed by Date of Posting
    http://www.cfids.org/xmrv/resource-listing.asp
  3. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    PDF file

    I've also attached the list as a PDF file, which will be updated regularly.

    Last update = 18th July 2011

    Attached Files:

  4. Jemal

    Jemal Senior Member

    Messages:
    1,031
    Likes:
    60
    Whoa... that's very nice Bob!
  5. jace

    jace Off the fence

    Messages:
    855
    Likes:
    170
    England
    :Sign Good Job: Great work, Bob! Thanks a million. Do we have permission to repost elsewhere?
  6. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    Hi jace,
    Thank you,
    Yes, anyone can repost it anywhere, preferably with a link to this thread so that people can check for updated versions.
    It's not quite finished yet, so there maybe some tidying up, corrections and additional info.
  7. kurt

    kurt Senior Member

    Messages:
    1,132
    Likes:
    175
    USA.Earth
    Bob,
    Nice list.

    You left out the key WPI patent: http://www.wipo.int/patentscope/sea...lter=&sortOption=&queryString=&tab=PCT Biblio

    This is a very broad provisional patent, I can't tell from the listing whether a permanent patent has been granted, this may still be provisional (although that usually only lasts for one year so they must be extending somehow). The WPI has patented all their original XMRV assays and even patented treatment of XMRV with any antivirals.
  8. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    Thanks for that Kurt... I've added it.

    And there's also a new patent application here, which I've also added:
    http://appft.uspto.gov/netacgi/nph-...ND&d=PG01&s1=mikovits&OS=mikovits&RS=mikovits
  9. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    435
    Raleigh, NC
    Fantastic Resource Bob - its great to be able to go straight to the categories and find the papers. :)
  10. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    Thanks Cort... That's why I did it... So I can find the info that I'm always looking for!
  11. dannybex

    dannybex Senior Member

    Messages:
    2,167
    Likes:
    514
    Seattle
    2 upcoming studies...

    Yes, great list, thanks for compiling and posting it Bob.

    I was wondering what are the two 'big' studies that folks keep talking about that aren't finished yet? One I guess is due at the end of the year, and then the other in 2012?

    thanks.
  12. Jemal

    Jemal Senior Member

    Messages:
    1,031
    Likes:
    60
    The BWG (Blood Working Group) study, results expected this summer.
    The Lipkin study, results expected by the end of 2011.

    So both should appear this year, though I wouldn't be surprised they are delayed. Such things happen a lot.
  13. GaryK

    GaryK

    Messages:
    71
    Likes:
    28
    Canada Niagara Falls
    Thank you Bob for this very valuable information! You've really done alot of work here.

    GaryK
  14. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    I added a large number of studies yesterday, added some categories, renamed some categories, and updated the PDF file.

    If anyone spots anything obvious that is missing from the list, then I'd be really grateful for any feedback.
  15. markmc20001

    markmc20001 Guest

    Messages:
    877
    Likes:
    80
    Looks like a ton of work! You want feed back? ut-oh you asked for it!

    It might be nice to have a clean thread, pdf or whatever, that outlines all the flawed logic, arguments, and unanswered questions around XMRV? All in plain english? Bob's effort at an unbiased view anyways...

    I know you addressed many of those recently on various threads, but they kind of got buried in a very long thread towards the end. Everybody has such a lowsy memory it could also serve as a good reference.

    Just a thought. It might be asking too much considering all you have done already.

    And then when you are done with all that! A magazine, journal,TV station would be nice...
  16. Bob

    Bob

    Messages:
    7,951
    Likes:
    9,880
    England, UK
    Hmm.... well, yes, you're right, I did ask for suggestions! :eek:

    I have been thinking about writing a blog/discussion about all the aspects of XMRV contamination, and this list was compiled in part to help me with that.

    I don't know if it will ever get done, because I've got to prioritise my list of things to do, but in the mean time, I suppose I could collate all of my recent posts re contamination, and post them in new blog or a new thread, in case helpful...

    That could be a good idea. Thanks for the suggestions mark!
  17. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    840
    UK
    Great work going on here - thanks Bob.
  18. kurt

    kurt Senior Member

    Messages:
    1,132
    Likes:
    175
    USA.Earth
    How would you determine which arguments are flawed? There is conflicting evidence, which I think muddies the water for determining which logic or arguments are flawed. Maybe better to outline the conflicting arguments without passing judgment as to which are flawed.

See more popular forum discussions.

Share This Page