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List of ME/CFS + POTS Related Autoantibody Panels (That Your Doctor Can Run)

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by Jesse2233, Sep 23, 2017.

  1. Jesse2233

    Jesse2233 Senior Member

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    Posting this in the hopes that it helps someone better determine an autoimmune etiology and move down an appropriate path of treatment (e.g. anti-inflammatories / immunomodulators / immunosuppressants).

    At very least these labs may point to a verifiable disease process when other labs are normal.

    Caveat: these autoantibodies can show up in healthy people, and any treatment based on them should be assessed in conjunction with one's clinical picture, other labs, and a healthcare professional.

    I am in contact with a researcher / immunologist in Sweden who is working on a new rhodopsin antibody assay for POTS. It is not yet available for public use, but I will update when it is.

    -------------------------

    The way I get doctors (in the US) to test for these is:

    1. Print out the lab order w/ appropriate test codes

    2. Take the lab order to a GP and say "I have a post-infectious autoimmune condition. My specialist would like to test for these antibodies" (all of which are true).

    3. I've not had any issues doing this with two different GPs. However, if this fails, one can consult a Integrative Medicine doctor or a Naturopath.
    -------------------------
    Note: The Quest and Lab Corp autoantibody tests need to be searched for individually


    Cyrex Array 5 - Multiple Autoimmune Reactivity Screen
    • Parietal Cell + ATPase antibodies
    • Intrinsic Factor antibodies
    • ASCA + ANCA antibodies
    • Tropomyosin antibodies
    • Thyroglobulin antibodies
    • Thyroid Peroxidase antibodies
    • 21-Hydroxylase (Adrenal Cortex) antibodies
    • Myocardial Peptide antibodies
    • Alpha-Myosin antibodies
    • Phospholipid antibodies
    • Platelet Glycoprotein antibodies
    • Testis antibodies
    • Fibulin antibodies
    • Collagen Complex antibodies
    • Arthritic Peptide antibodies
    • Osteocyte antibodies
    • Cytochrome P450 (Hepatocyte) antibodies
    • Insulin + Islet Cell antibodies
    • Glutamic Acid Decarboxylase 65 antibodies
    • Myelin Basic Protein antibodies
    • Asialoganglioside antibodies
    • Alpha-Tubulin + Beta-Tubulin antibodies
    • Cerebellar antibodies
    • Synapsin antibodies
    CellTrend CFS/POTS Diagnostic
    • Anti a-1-adrenergic antibodies
    • Anti a-2-adrenergic antibodies
    • Anti b-1-adrenergic antibodies
    • Anti b-2-adrenergic antibodies
    • Anti-muscarinic cholinergic receptor 1 antibodies
    • Anti-muscarinic cholinergic receptor 2 antibodies
    • Anti-muscarinic cholinergic receptor 3 antibodies
    • Anti-muscarinic cholinergic receptor 4 antibodies
    • Anti-muscarinic cholinergic receptor 5 antibodies
    Cunningham Panel
    • Anti-Dopamine Receptor D1
    • Anti-Dopamine Receptor D2L
    • Anti-Lysoganglioside GM1
    • Anti-Tubulin
    • CaM Kinase II
    Lab Corp
    • Anti-Mitochondrial Ab
    • Anti-Smooth Muscle Ab
    • Anti-Cardiolipin Ab
    • Rheumatoid Factor IgM
    Quest Diagnostics
    • Beta 2 glycoprotein IgG, IgM, IgA
    • Lupus anticoagulant
    • Anti-phosphatidylserine IgG, IgM, IgA
    • Anti-prothrombin IgG (IgM is not currently available due to reagent shortage)
    • Anti-phosphatidylserine-prothrombin IgG, IgM
    • Anti-Annexin V IgG, IgM
    • Anti-phosphatidylethanolamine IgG, IgM
    • ANA by IFA
    • ENA
    • SS-A
    • SS-B
    • Anti TTG IgA
    • Anti Glaidin
    MAYO Autoimmune Dysautonomia
    • Striational (Striated Muscle) Ab, S
    • Anti-Neuronal Nuclear Ab, Type 1
    • N-Type Calcium Channel Ab
    • Ach Receptor (Muscle) Minding Ab
    • AcChR Ganglionic Neuronal Ab, S
    • Neuronal (V-G) K+ Channel Ab, S
    • GAD65 Ab Assay, S
    • P/Q Type Calcium Channel Ab
    MAYO Autoimmune Encephalitis
    • NMDA-R, Ab CBA, S
    • Neuronal (V-G) K+ Channel Ab, S
    • LG1- IgG CBA, S
    • CASPR2 - IgG CBA, S
    • GABA 8-R Ab CBA, S
    • AMPA-R Ab, CBA, S
    • ANNA-1, S
    • ANNA-2, S
    • AGNA-1, S
    • PCA-1,S
    • PCA-2, S
    • PCA-Tr, S
    • Amphiphysin Ab, S
    • ACh Receptor (muscle) Bind Ab
    • CRMP 5-IgG, S
     
    Last edited: Sep 24, 2017
    ryan31337, Mary, pibee and 19 others like this.
  2. *GG*

    *GG* Senior Member

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    This would be cool as a PDF or similar, make it portable and easy to share with others!

    GG
     
    veganmua, MEMum and Jesse2233 like this.
  3. Jill

    Jill Senior Member

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    Wow wouldn't it b great to get these done . Doubt half of these can be done in NZ .
     
    mrquasar, Ravn, pattismith and 3 others like this.
  4. MEMum

    MEMum Senior Member

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    Only managed to have about 5 of these done in UK!
     
    pattismith likes this.
  5. notmyself

    notmyself Senior Member

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    wow..nice info,thanks!
     
    Gingergrrl and Jesse2233 like this.
  6. AdamS

    AdamS Senior Member

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    Thanks for taking the time to put this together @Jesse2233 greatly appreciated.
     
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  7. Jesse2233

    Jesse2233 Senior Member

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    Done, see attached
     

    Attached Files:

  8. Vojta

    Vojta Senior Member

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    It would be nice to know approximate price for panels too.
    I have done Cunningham and celltrend. I'm positive for anti dopamin 1, anti tubulin and 2 celltrend.
    I have wide range of neurological symptoms so autoimmune encephalitis is definitely possible but dr. did only these two. I would like to do other panels before starting rituximab though because it would be helpful to have more evidence to fight medical system.
     
    MartinK, pattismith, bspg and 4 others like this.
  9. Rossy191276

    Rossy191276

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    Cheers Jesse great info
     
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  10. Rossy191276

    Rossy191276

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    I have seen a lot on cell trend and done those but if the others are there opinions on those to prioritise or have most evidence or promise to link to ME?
     
  11. Jesse2233

    Jesse2233 Senior Member

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    Anti-cardiolipin pops up in a lot of patients

    MAYO panels are more likely to be taken seriously by neurologists and may lead to insurance coverage w/ certain plans, indications, treatments

    Cunningham Panel is more common in post-infectious cases
     
    zenzen likes this.
  12. Vojta

    Vojta Senior Member

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    @Jesse2233
    Do you know how much is Cunningham panel taken seriously by neurologists by any chance (in europe)?
    I'm afraid I would hit the wall again if I demand more neuro autoimmune testing.
     
  13. Jesse2233

    Jesse2233 Senior Member

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    I'm not sure. Perhaps if you printed the accompanying University of Oklahoma studies
     
  14. Ravn

    Ravn

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    If you, or anybody else, can find any that can be done in NZ, please let me know where and how.
     
    Hutan likes this.
  15. Hope78

    Hope78

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    Wow, great information! I am just researching which antibodies to test.
    Main symptoms are leg weakness (thighs) with frequent cramping, tingling, twitching, numbness, cramping in the calfs, worse when I walk a few steps. The same day my gastroparesis (paralized stomach) started, so I always thought the both conditions were interrelated as both are neurological in nature. Doctors have no interest in finding out the cause, but I think it could be autoimmune related.
    There is also an autoimmune panel for gi-conditions from the Mayo-clinic:
    https://www.mayomedicallaboratories.com/test-catalog/Overview/37429
    But this seems to be nearly identic with the dysautonomia panel.

    Any suggestions which antibodies make probably sense to test with the combination from muscle problems and gastroparesis? Have to pay this on my own, as I have the kind of "just accept it and live with it-doctor"

    Thank you!
     
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  16. Jesse2233

    Jesse2233 Senior Member

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    @Hope78

    My best guess would be either the MAYO panels you mentioned or CellTrend Abs given their implication in dysautonomia. Of course these other Abs could be implicated as well (or none could)
     
    Gingergrrl likes this.
  17. bspg

    bspg Plant Queen

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    I wonder if Medicaid would cover any of the mayo panels.
     

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