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Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. This second article in a 2-Part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS....
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List of ME/CFS abnormalities explainable by the GD-MCB hypothesis

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by richvank, Aug 17, 2011.

  1. richvank

    richvank Senior Member

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    Hi, heapsreal.

    Thanks for the comments. I've got the deficiency of perforin secretion in the list as number 15, and I think that the low cytotoxicity of both the NK cells and the cytotoxic T cells is due to their low perforin, as Kevin Maher (who was in Nancy Klimas's group) reported a few years ago. I probably should spell that out. I've got viral reactivation in the list as number 9. It may be that more T cells are being produced to compensate for their poor function, as you suggest.

    Best regards,

    Rich
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    It all turns into a viscious circle i guess with perforin defiency comes interferon problems which then effects cd lymphocytes and nk cells. U can start to get lost when looking into the different immune dysfunctions.
    The bigger study to this http://www.ncbi.nlm.nih.gov/pubmed/12536237 has only just finished so will be interested to see their final results of dim and bright nk cells, i also was told that they are doing cytokine studies that havent been done before in cfs as well as a few other things that werent elaborated on. The role of this study i believe was to find a diagnostic test for cfs i hope they continue to look into ways of improving our immune system, maybe using the glutathione depletion model.

    cheers!!!

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