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Lipopolysaccharide Antagonist Molecule AM-12

JPV

JPV

ɹǝqɯǝɯ ɹoıuǝs
Messages
858
Has anybody heard of this before?
Lipopolysaccharide Antagonist; AM-12

Lipopolysaccharide Antagonist; AM-12 is an antagonist of LPS signaling without activating the inflammatory cascade. This Lipid A analog contains a glucopyranoside core, hydrophobic ether substituents, and an amino acid to provide an ionic character. It has been shown to be a very effective inhibitor of LPS-induced TNF-alpha production in human macrophages.

Highlights:
  • Blocks pro-inflammatory response to lipopolysaccharides (LPS)
  • No toxicity or agonist activity observed (range of 0.2 - 40 uM tested)
  • TNF-alpha inhibition (IC50) of 470 nM, the lowest reported for a monosaccharide compound
  • Mimics classic Lipid A analogs, however, lacks the toxic disaccharide core
Endotoxins (Lipopolysaccharide or LPS) are a major component of the cell wall of gram-negative bacteria and are released from the bacteria as they are destroyed. LPS induces a strong response from normal immune systems and can lead to sepsis. LPS binds the CD14/TLR4/MD2 receptor complex, which promotes the secretion of pro-inflammatory cytokines in many cell types, but especially in macrophages. LPS is composed of three structural regions, one of which (the Lipid-A region) is largely responsible for the toxic activity.
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M

msf

Senior Member
Messages
3,650
Looks promising, at least for those with leaky gut. I don´t know if you would want to do this with a pathogenic bacteria though, I guess it would depend on how virulent it was.
 
alex3619

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
LPS is a super antigen. It can drive someone with a LPS based bacterial infection into septic shock. Blocking LPS will not stop the immune system from fighting a bacterial infection. It will just slow down the severity and speed of the immune response. In anyone with a severe immune response this would be a good thing.

I would like to see human clinical trials if the research keeps showing results.
 
M

msf

Senior Member
Messages
3,650
I was referring to its potential use in ME, rather than in sepsis.

KDM has talked about the potential efficacy of such a approach in Lyme.
 
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