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Life Extension says it's been proven diabetics have mitochondrial deficiency

Discussion in 'Post-Exertional Malaise, Fatigue, and Crashes' started by triffid113, Oct 11, 2013.

  1. madietodd

    madietodd Senior Member

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    East Coast, USA
    Have you researched brands of resveratrol? I'm mostly wondering if soft gels are better than tablets.
  2. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    I have done some looking at brands, but not nearly enough to make recommendations.
  3. Ema

    Ema Senior Member

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    I'd like to know this as well. Maybe it deserves its own thread?
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I just thought i would add my recent experience in relation to this subject.

    I have always been one of those guys who put weight on easy. pre cfs i was probably more and meso/endo morph from exercising alot and i ate healthy but always had that puppy fat, which i think now was a sign of insulin resistance but i kept it somewaht under control pre cfs with exercise etc.

    cfs hit and my activity dropped and the weight climbed actually not too bad just went soft and mushy lol, i guess this is a familiar storey to many. The initial weight i put on i lost most of it by sticking strictly to low carb diet, any change and i would whack the weight on. cholesterol also went up when i increased my carbs, seems against the general health advice that bacon and eggs for breakfast, a big fat juicy steak with some salad for dinner etc and my cholesterol numbers improved as well as my weight.

    Over time, diet alone just hasnt been enough, just too sedentary. I use mito supps ie lipoic acid, q10, nac and acetl carnitine, there the main mito supps plus fists full of other supps too. I have added metformin and this helped me to lose more weight and i could actually eat some carbs without too many issues. I am prone to reactive hypo episodes after eating too many carbs, so i would have an occassional carb mung out every so often for sanity, mostly it just made me feel sick.

    The last few months i have put probably 10kg on without any changes in diet or exercise(watching sport on tv). The only thing i have changed in the last few months was stopping acetyl carnitine when i ran out of, which i was taking 500mg every morning. I have been having more hypo episodes where i get really sweaty and weak until i eat something, generally i keep a protein drink nearby. cant say for sure but seems abit more then a coincidence?? Recieved my acl carn today and will start it tomorrow.

    I think the whole mitochondria/insulin resistence thing is an issue of mine. I also initially had some improvement in this area when on testosterone cream but the last few months i dont think its working, apparently common for guys to all of the sudden be unable to absorb creams, next step i will talk to my doc about testosterone injections. Optimum testosterone also play a big role in improving insulin sensitivity and probably mitochondria issues in men.

    For me it looks like i need the very low carb diet, metformin, all the mito supps and testosterone.

    I think this type of stuff is just a comorbid condition thats common in ME. So ME may not be directly deadly just indirectly deadly through other comorbid issues??? Something we need to keep on top off.

    cheers!!!
    taniaaust1, Mij and merylg like this.
  5. taniaaust1

    taniaaust1 Senior Member

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    I'd like to point out that the above is a common myth. Having another illness does not exclude one from being able to get a ME/CFS diagnoses as long as the other illness cant explain ones symptoms.

    This has been twisted with many ending up thinking that one cant have other conditions and ME/CFS.
    alex3619 likes this.
  6. FWIW, I have had terrible post-exertional symptoms for about 15 years, and 5.5 years ago, I was diagnosed with adult onset Type 1 diabetes. I'm not sure what the link is, but I strongly suspect there is one, in my case. For those of you who don't know, Type 1 has an autoimmune causation, where the body's immune system attacks the insulin producing islet cells of the pancreas. This is why we require insulin by injection. Anyway, I was - believe it or not - a little excited to discover I had diabetes, only because I thought it was the answer to my post-exertional problems. However, my symptoms have in fact become worse, not better.
  7. xks201

    xks201 Senior Member

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    you are absorbing it. It is just converting to estrogen because aromatase is all over the skin.
    Wilted_Iris and heapsreal like this.
  8. Wilted_Iris

    Wilted_Iris

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    Different antagonists yet similar/same results.

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