I know there are those here who strongly disagree, but I believe that long term diabetics (not young ones) have CFS (mitochondrial dysfunction). I know the diagnosis criteria EXCLUDES diabetics but I think this is rather unfair and arbitrary as if people can only have one ailment at a time (ludicrous in fact). I can attest that my father had MANY ailments all at the same time... I have always thought CFS ran in my family (long before I knew there was a name for it) and I used to think of it in terms of "some kind of problem with B vitamins" before I knew about the methyl cycle (so like 45 years ago). So now I had my and my father's genes mapped and we both have 18 of 30 genetic defects mapped, many in the methyl cycle (yes, I was right all those years, we have a B vitamin issue). We did not have all the same defects nor the same severity, yet the general screwed-up-edness was similar. He did not have allergies so I suspect I have additional genetic problems he did not have. The thing is that I could look right up my Dad's side of the family tree and see severe fatigue issues everywhere there (and none on my mother's side - my Dad lucked out on marrying someone with the energy to take care of him). The diabetes in my family is ALSO all up my Dad's side. Medical science just dismissed their life-altering fatigue as diabetes, yet every other diabetic I knew growing up had plenty of energy (rode frequently in bike marathons, waitressed in busy restaurants, etc). So I told my Dad and my Aunt long time ago that I thought they had some kind of fatigue issue in addition to diabetes. My father's side of the family didn't use wheelchairs, they just never went anywhere or did anything...they didn't WANT to, because depression went along with the fatigue. So I am just saying that it is proven now that diabetics have the same mitochondrial issues that CFSers have, possibly different cause, although I think you'll find there are multiple causes even among classical CFSers. Those who dismiss this as diabetes think that those with diabetes and low numbers of mirtochondria (which sounds like eventually all diabetics have) only have to eat 'properly' to have this problem go away, but I can speak from experience that it's not so easy as that. If diabetes is in your genes eating a certain way might never do the trick nor be possible. If you can't absorb sugar or utilize it properly you would be surprised at how useless a "supposed to" or "should" diet is. (I have been diabetic twice and beat it - because I was young and it THEN was caused by too much stress (divorce) and its effect on my diet / self - care), but over 50 w/o hormonal (gene expression) help, I don't think diet would help enough to - well - help. I developed inability to break down glycogen (panic/low blood sugar) forever after age 50 and I couldn't play around with that with little things that may/may not have effect in a million years so I jumped right on hormone replacement until I found a strategy that works. So I have had some sort of blood sugar issue I have had to fight all my life - as a kid it took little to fend off, but as I got older it got HARDER. I do not believe w/o hormones it would have been possible. So, I am making the case that diabetes as a cause of CFS is just as relevant as any Epstein-barr or lyme or any other cause. The end result is mitochondrial dysfunction. And the path there is not remotely easy to fix. (So for instance insulin did NOTHING to fix it). I think it's bogus to exclude diabetics from having CFS. It's just some arbitrary rule w/o basis in what's really going on at the cellular level. I'm just putting this out there. My opinion. Unsolicited so we know what that's worth.