Has anyone tried licorice root for orthostatic intolerance? My daughter has POTS and NMH. She was unable to tolerate Florinef because it caused depression. Midodrine at her current dose doesn't seem to be helping much, but a higher dose causes her heart to pound. She is on atenolol, and has increased salt and fluids. While these are helpful, they aren't enough. Her doctor suggested adding pseudoephedrine and licorice root. How quickly will I be able to tell if the licorice root is helping? Are there any side effects I should be concerned about? I get the feeling her doctor doesn't have much experience with it, or anything beyond the first few drugs that are typically prescribed.