For a long-time I've noticed a pattern that if slept less than 8 hours but more than, say, 6, my symptoms the next day were less severe. And more than the hours per say, it seems less REM sleep made me feel better. Days where I would sleep in and dream a lot where usually accompanied by much greater fatigue and headaches. It's almost as if I need to get deep sleep to not feel totally fried the next day, but the more I sleep the more likely I'm getting more REM sleep--which harms me. Of course, I realize that observations flies in the face of what we know of the importance of REM sleep. B Now, I know there is a hangover effect that you get when you sleep much more than usual. This is not what I'm referring to. As long as I sleep more than 8 hours I will almost be guaranteed to feel crummy. Some of my worst fatigue crashes have come after a solid nights sleep. Fatigue episodes that last weeks. The only thing I can think of is that part of my condition is an overactive immune system. Less sleep reduces immune system activity. Strangely enough, I've had similar experiences with alcohol. There have been a few times where I have had a little too much to drink (I rarely do this) and to my surprise I woke up feeling great. Again, my only thoughts on this have to do with reducing immune system activity, though I'm aware of the interrelationship between sleep quality and alcohol consumption, so the second observation may in fact be the first in disguise. This isn't to say I feel great during these days. I'm still sick. Still get fatigued and have headaches. But something has been marginally improved. I've tested this by restricting my sleep, namely waking up earlier to avoid REM sleep. It does seem to be a pretty stable result. Has anyone experienced this? I should note, the first symptom I developed after getting sick was a total loss of sleeping ability. I've tried everything under the sun when it comes to sleeping and the only thing that gets me to sleep is amitryptaline.