Hi everyone, I haven't posted much here, but it's great to see such a thriving community helping each other out. Quick background- I've had CFS for 4 years now and strange symptoms for about 3 years before that. I'm 28, male. My main symptom during that time has been fatigue with post exertional malaise, along with some more minor things like difficulty keeping warm, dry eyes, poor sleep, etc. I used to get sore legs if I walked too much, but a month and a half ago it got much worse all of a sudden and I can hardly walk anymore. I got a wheel chair on Thanksgiving and that helps, but I'm worried my legs are now atrophying from not walking at all which will only make it worse long term. I'm hoping if I describe the symptom a bit here someone can offer some advice on whether this is likely CFS related and if anyone has any therapy recommendations. The pain is a broad ache type, only in the back of the legs, in the back of the thighs and the back of my calves, but not the top of my thighs at all. It's brought on by walking. Specifically walking, crawling doesn't even seem to trigger it much. It's bad enough now that walking to the kitchen and back can trigger it so I've tried to stay in the wheelchair or in bed almost all the time but that's only going to make it worse in the long term. But it is triggered by walking because if I stayed in bed/wheelchair all day it would not hurt at all. If I ignore it and keep walking, it gets worse and worse until it's really painful, so I can't just push through it (as seems to be the pattern with CFS ) Interestingly, my arms don't seem to hurt at all from using the wheelchair, so it's not a general muscle use pain throughout the body, there's something specific happening in the back of the legs. There is a muscle in the perineum that also has a similar problem that is made worse by orgasm. :Sign giggle: and that area seems pretty close to the back of the legs, and orgasm is a muscle use so I'm thinking they may be related. Only thing that helps so far is hot baths and massage. Which are pleasant treatments , but not terribly effective. A pain doctor family friend recommends low dose Prapranolol for pain with CFS, but I'm trying not to take meds if I can help it for fear of side effects causing more problems. Anyone have any thoughts? Has anyone had any luck with Prapranolol? Thanks!!!!!!!!!