In August I had a sudden onset crash and relapse of selected symptoms. However, in the dissection of it the clues that were there much sooner I coul;d have headed it off if I had any idea it was going to get that bad just becasue of a change in the Jarrow. First, I had gotten careless and ignored several minor symptoms. I was running around like an invulnerable 18 year old. I was hiking 4 to 10 miles daily, 2000-4000 vertical feet up and down every day just running around to my RV out in the woods at the far end of dirt roads up on a hillside, the clubhouse, pool, hottub, courts and other facilities and of course intentional hikes into the hills. I had noticed a number of symptoms including the types of pain associated with CNS neurological problems and specifically CNS-mb12 deficiency. I was using a mix of 30mg injected of 3 star mb12 to act as a carrier of 33mgs of sublingual Jarrow and ENZY. That had worked for a couple of years. The percentage of 5 star mb12 was enough to make a noticable difference and keep me on the healing side of equilibrium. At some point early in this year or so, the Jarrow mb12 changed. It was no longer 5 star. The 3mg daily of ENZY mb12 wasn't enough against the background of the other mb12s. The sudden onset happened on a record hot day in August. Lots of years we would have had a nighttime frost by then with overnight lows in the 30s at the bottom of the gulch. Not this year. We could go on midnight moonlight walks in the 70s on the hillsides and 50s at the bottom. We had formed a fryers club group that got together and made fresh potato chips, sweet potato chips and such once a week. We had 3 fry stations going on various gas grills and camp stoves. The kids of all ages enjoyed it. I had a white RV at my back, the sun and cookstove in front and just didn't drink enough water. Suddenly I almost fell over and was helped to a chair in the shade. The dehydration and overheating were all the stress needed. I had a sizable demyelination suddenly. I had back the worse pain I have had in 9 years, terrible dizziness, brain fog and the intensely painful tight muscles from screwed up nerves. The pain had been building slowly since July. My mucous had been getting thicker and jellied for a few months. I had terrible paradoxical folate deficiency despite plenty of folate (methyl trap from lack of "active" mb12?). The 10 hour drive there at the beginnig of August was a breeze. The drive home in mid september took two gruesome days. The sleep disorder was back. My body had plenty of energy but I couldn't stay awake. My cell reproduction was impaired. And everything else was neurological. When I got back home to my new order of vitamins I started on 30mg daily of ENZY as 6 times 5mgs for 2 hours+ each batch. I had CNS mb12 startup all over again for the third time. I started Anabol dibencozide with boron. I had CNS adb12 startup for the third time. The first time was when I started them 9 years ago. The second time was after the glutathione trials after I was able to increase the methylfolate enough to overcome the induced defciency. This was the third mb12 and adb12 startup experience for the CNS only, not the body. The mucous started turning around in a week. The mood and personality changes went into the volitile recovery mode. The nerves started tingling intensely and shooting pains and all the rest as they started to recover feeling again. I'm 6 weeks into the recovery and there is no doubt at all that the nerves are recovering again. Basically all the FMS CNS symptoms came back with a vengence. They also happen to be the Subacute Combined degneration symptoms which never full healed. Only the mucous changed in the body, all the rest was caused by CNS changes. I also had bouts of vomitting with a cough or sneeze causing acute nausea, again a famliliar neurological problem form 9.5 years before. None of the 3 brands I tried of dibencozide made any difference while I was taking the Jarrow. As soon as I elliminated all the b12 except 30mg of ENZY a day, having 100% 5 star mb12 at a high enough saturation to penetrate the CSF/CNS I had a startup experience with the adb12. Somehow, the absorbtion or transport or something went wrong with the adb12 when not getting enough 5 star mb12. That appears to demonstrate an aspect of the Deadlock Quartet, that adb12 is blocked from effectiveness by lack of enough 5 star mb12. The onset was just as sudden as in 1987 and included the disabling dizzyness, intense pain, muscle spasms and pain and vomitting, same as 1987. The big difference was no fatigue. Also I was able to start reversing it in weeks instead of nearly 17 years. If all goes as last time I should be largely recovered neurologically in another 8 months. The dizzyness was gone in days of 10mg daily of ENZY and elliminating the Jarrow. The pain is now about 20% of what it was. The muscle spasms are fading and responding to massage. The vomitting hasn't happened in a week and I'm slowly regaining feeling in my feet. The mood and personality changes are volitile and hopefully will settle to normal over the next months. It makes me very irritable (Mr Hyde) and depressed and apathetic. So, despite taking plenty of mb12, it wasn't good mb12 except for a little. So the percentage of 5 star makes a difference. This is the third time and way that has been confirmed to me. Lack of adequate 5 star mb12 creates a block that prevents utilization of adb12 and methylfolate. This looks like a good demonstration of the Deadlock Quartet. Don't get careless as I did. Pay attention to changes in symptoms. Don't let them sneak up on you. This is very similar to what somebody else had happen when they discontinued the adb12 becasue it "wasn't needed" any more. After some months a subset of symptoms came back including sleep disorders. Good health to you all.