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Leaky Gut: Normal with Intense Exercise, Worse with Ibuprofen

Discussion in 'Other Health News and Research' started by MishMash, Dec 13, 2012.

  1. MishMash

    MishMash

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    Just when I thought that leaky gut was a symptom usually exhibited in hard-to-diagnose illnesses like ME/CFS, mainstream medicine admits it is actually quite common. Intensive exercising, in this case cycling, causes a small degree of intestinal leakage in healthy people. This is explained by the fact that blood is withdrawn from the intestinal wall, weakening its structural integrity.

    http://www.ncbi.nlm.nih.gov/pubmed/21811592

    So why do doctors keep telling us there is no such thing as "leaky gut"? Or it's a made-up diagnosis by alternative medicine practioners? People with ME/CFS have lower blood volume and in many cases weaker connective tissues. So of course leaky gut is going to be more of an issue for us. Probably explains IBS, digestive issues, low-level toxicity of the blood stream. Not to mention, eventual adrenal stress, fatigue, PEM.

    Not only that but the New York Times reported that Ibuprofen made the leaky gut even worse. If you are a patient, and you have leaky gut, then taking Ibuprofen will turn your intestine into swiss cheese (an exaggeration). http://well.blogs.nytimes.com/2012/12/05/for-athletes-risks-from-ibuprofen-use/

     
  2. xchocoholic

    xchocoholic Senior Member

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    Hi mishmash,

    Great find. I'm not sure if everytime our guts become leaky it's actually a problem tho.
    I haven't researched it but I supect there are times when opening up those junctions and allowing other
    particles through needs to be happening. If it's happening when we're exercising maybe it's a mechanism
    for better food absorption.

    There's a drug being developed called zonulin that will close these but there's a lot of caution surrounding
    this.

    Btw. I see an integrative doc and have been tested and treated for leaky gut. The dx of
    leaky gut is becoming
    more accepted because integrative doctors are mds who also use holistic methods. Fwiw, I did
    all this and still responded to the mast cell protocal.

    Tx .. X
     
    MishMash likes this.
  3. Waverunner

    Waverunner Senior Member

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    MishMash, thanks for this info. I have the same question as you. Why does the medical field not recognize a problem, although studies point to the fact, that it is there?
     
    redrachel76 and MishMash like this.
  4. Valentijn

    Valentijn Senior Member

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    Because they think we're psychosomatic nutjobs who aren't really sick. Ergo all symptoms of physical illness must be denied or attributed to our inactivity.

    I'd like to see them explain my body swelling up now every time I eat gluten or egg whites. It's progressed to even trace amounts being sufficient to trigger a reaction, but there's no true IgE allergy present.

    I think this same thinking is applied to non-ME patients as well: if there's not an easy answer/pill for it, pretend it's not there until the patient goes away.
     
    redrachel76, MishMash and xchocoholic like this.
  5. xchocoholic

    xchocoholic Senior Member

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    I'm sure there are those who know we're not nutjobs and those who aren't smart enough to figure this
    out. I had a doctor once who's sister had fm so she knew what it was via her medical training. And she was dabbling
    in the holistic arena because she knew about food intolerances. The last time I saw her she was unaware of the
    mast cell connection.. I'm guessing her med school training got in the way of her solving it tho.

    Allergies aren't always going to show up on normal traditional testing. You may get better info from stool tests.

    Tc .. X
     
  6. xchocoholic

    xchocoholic Senior Member

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    Btw. Traditional med calls it intestinal permiability.

    I've been discussing why this wasn't being
    addressed by traditional docs with others on the web since 2006. The conscensus was that it's because big
    Pharma doesn't own a piece of the pie. The tests aren't owned by big pharma and the treatments
    are holistic. So there's no money in it for them.

    The money (patient + insurance) is currently divided by traditional or holistic
    medicine. Most feel the need to pick a side. The easiest path for an md is to plead ignorance and give out drugs like they were candy.

    Integrative doctors, who are both mds and holistic use both meds, supplements and diet as well
    as tests provided by both sides. These docs are better equipped to help their patients with any
    illness.

    Tc .. X
     
  7. Waverunner

    Waverunner Senior Member

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    If it was only for CFS, I could agree with you. But Leaky Gut is not restricted to PWCs, it seems to be part of many diseases, including HIV, autism, allergies etc.. Why don't they look more into this?
     
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  8. xchocoholic

    xchocoholic Senior Member

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    Money. Money. Money.

    If they looked for root causes of illnesses, they'd find them. Why do you think they're not
    looking for heavy metals / mercury poisoning ? The lawsuits that would follow would be enormous.

    They can't own up to all the chemicals they're allowing in our food supply either. How about parasites ?

    It's not to their advantage to cure us. Healthy patients are ex patients.

    I doubt every doctor knows anything about looking for root causes. They've been taught to say the don't know what causes x, y or z. If you read the mayo clinic site or webmd, they're always saying we don't know this or that. And warning
    about trusting holistic treatments.

    Then there's arrogance. I've had a couple of doctors look at me like there's no way a patient could possibly know more than they do. The mere mention of google makes their eyes bug out. Lol .. Sadly, I get a great amount of pleasure
    from watching this reaction. ; )

    I understand there are some unknowns but you can't solve a puzzle by leaving the pieces in the box.

    Tc .. X
     
    MishMash likes this.
  9. ukxmrv

    ukxmrv Senior Member

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    I saw a doctor at one of the London hospitals who also treats HIV/AIDS patients. She said that for the last couple of years this area of the study (the gut) had taken off at conferences and was going to be the big area for research next.
     
    MishMash likes this.
  10. alex3619

    alex3619 Senior Member

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    One of the issues I suspect is the the original hypothesis of leaky gut had bacteria and candida going from gut to blood stream in quantity. This was clearly implausible, and so was rejected. They remember that, and I am not sure are aware that modern versions of leaky gut are about excessive translocation of inappropriate molecules, and sometimes large molecules. Leaky gut is impossible without death, leaky gut occurs all the time. The problem is that there are different ideas about leaky gut, and too many remember the first unlikely hypothesis. Modern versions are highly substantiated, but who goes looking? Most doctors are not even aware of findings of lipopolysaccharide in ME and CFS patients. If they were aware, where aside from the gut is it coming from?
     
    MishMash likes this.
  11. MishMash

    MishMash

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    If the HIV/AIDs researchers are going to be looking at it, then there will probably be serious, well-done studies on gut permeability. Because the AIDS people do not mess around. The advocates do not tolerate imbecile politicans or pompous medical authority figures pontificating about what are and are not absolute medical truths.

    I am not gay, but I have to give gays great credit. They do not quit. Their communication and organizational skills are fantastic. All sick people will benefit from the huge amount of effort their community has put into understand of the immune system.
     
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  12. Waverunner

    Waverunner Senior Member

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    Alex already pointed out some reasons why research does not focus on intestinal permeability. A doctor told me, that intestinal research always suffers from the fact, that bacteria and feces are not very pleasant things. Moreover the scientists will not get the attention they deserve, compared to scientists for cancer and other diseases. Another reason could be that right now, it is very hard to actually measure the consequences of increased intestinal permeability. What cytokines or products do you measure in blood, in order to show the detrimental effects of a leaky gut? What effects does it have on the brain? These questions can be solved but funding is still a problem.
     
    merylg, alex3619 and MishMash like this.

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