Low-dose naltrexone (LDN) can be considered to be an immunomodulator. Should it be pulsed? Many immunomodulators (such as Imunovir, Nexavir, artesunate, and azithromycin) are best used on a pulsed, on/off basis. Dr Cheney often makes the point that these immunomodulators lose their effect if you do not take regular breaks from them. Regular breaks means taking them on an on/off regimen, such as for example: on for 5 days, off for 2 days; and/or on for 3 weeks, off for 1 week. However, other immunomodulators like oxymatrine (this is assumed to be an immunomodulator) should not be stopped if you are deriving benefit from it, as according to Dr Chia, stopping oxymatrine if it is working for you generally causes relapse of symptoms. Anyway, I wonder if there is any advice given for pulsing LDN, and whether anyone has tried a pulsed LDN regimen, and found it better than taking LDN continuously? Note that LDN may not work unless you also take vitamin D3.