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The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
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LDN is an immunomodulator; should it be pulsed?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Hip, Nov 14, 2012.

  1. Hip

    Hip Senior Member

    Low-dose naltrexone (LDN) can be considered to be an immunomodulator. Should it be pulsed?

    Many immunomodulators (such as Imunovir, Nexavir, artesunate, and azithromycin) are best used on a pulsed, on/off basis. Dr Cheney often makes the point that these immunomodulators lose their effect if you do not take regular breaks from them. Regular breaks means taking them on an on/off regimen, such as for example: on for 5 days, off for 2 days; and/or on for 3 weeks, off for 1 week.

    However, other immunomodulators like oxymatrine (this is assumed to be an immunomodulator) should not be stopped if you are deriving benefit from it, as according to Dr Chia, stopping oxymatrine if it is working for you generally causes relapse of symptoms.

    Anyway, I wonder if there is any advice given for pulsing LDN, and whether anyone has tried a pulsed LDN regimen, and found it better than taking LDN continuously?
    heapsreal and Omar88 like this.
  2. alex3619

    alex3619 Senior Member

    Logan, Queensland, Australia
    Hi Hip, that is a good question. I have wondered about it myself. So far I have not tested this. Bye, Alex
  3. Ninan

    Ninan Senior Member

    For me it stopped working after taking it every day for a few weeks. Maybe it would have lasted longer with pulsing.

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