Although I haven't been tested (and am not sure such a test exists) I suspect that low endorphins were a problem before I got sick and are even more of one now. I started LDN (1.5 mg to start) 2 weeks ago and added d-phenylalanine at 1.5 - 2 g a day a week ago. This combo hasn't had a profound effect on my health or actual energy levels (yet?) but mentally I feel much more like myself than I have in quite a while. Things seem funny again, I'm enjoying the company of others even though I can't really keep up with conversations like I used to, I don't fantasize about killing myself constantly; you know, the little things. I'm wondering if I will counteract the effects of LDN by adding another substance that increases endorphins (well enkephalins via inhibiting their degradation) or is this potentially a way to accelerate healing? I could find very little reference to using them together, just one secondhand recommendation. Thanks for your thoughts.