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laser-evoked potential findings in fibromyalgia patients in light of clinical & skin biopsy

Discussion in 'Other Health News and Research' started by Ecoclimber, Dec 26, 2013.

  1. Ecoclimber

    Ecoclimber Senior Member

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    Mercer Island Wa
    J Neurol. 2013 Dec 24. [Epub ahead of print]
    Update on laser-evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features.
    de Tommaso M, Nolano M, Iannone F, Vecchio E, Ricci K, Lorenzo M, Delussi M, Girolamo F, Lavolpe V, Provitera V, Stancanelli A, Lapadula G, Livrea P.
    Author information
    • Basic Medical Sciences, Neuroscience and Sensory System Department, SMBNOS, Policlinico General Hospital, Bari Aldo Moro University, Via Amendola 207 A, 70124, Bari, Italy, m.detommaso@neurol.uniba.it.
    Abstract
    In fibromyalgia (FM), reduced habituation of laser-evoked potentials (LEPs) suggests a dysfunction of pain processing at a central level.

    In this study, we aimed to further examine the nociceptive pathways at the peripheral to the central level in a large group of FM patients by means of LEPs and skin biopsy, in light of healthy controls findings and main clinical features.

    One hundred and ninety-nine FM patients and 109 age- and sex-matched controls were submitted to LEPs by the dorsum of the right hand and the skin over the right chest and knee tender point stimulation. S

    kin biopsy was performed in 21 randomly selected FM patients and 60 age- and sex-matched controls.

    The mean N2-P2 amplitude was reduced in the whole FM group, with normal or even increased values in patients with migraine as comorbidity and reduced values in other patients including those presenting with distal sensory deficits.

    All patients had reduced N2-P2 habituation in respect to controls. In the FM group, LEPs habituation was correlated with pain at tender points and bad quality of life.

    Epidermal fiber density was significantly reduced in FM patients versus controls, and correlated with N2-P2 amplitude by the hand and chest tender-point stimulation.

    Dysfunction in the nociceptive system at both the central and peripheral levels may concur to explain phenotypical eterogeneity and clinical symptom complexity in fibromyalgia.

    Eco
    alex3619 and Marco like this.
  2. Marco

    Marco Old blackguard

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    Near Cognac, France
    Yet more evidence of small fibre neuropathy in FMS to add to these two :

    http://www.ncbi.nlm.nih.gov/pubmed/23474848

    http://www.ncbi.nlm.nih.gov/pubmed/23748113

    I don't find Oaklander's (second reference) suggestion that 41% of her cohort were 'misdiagnosed' with fibromyalgia rather than small fibre polyneuropathy particularly convincing.

    Evidence seems to be tilting towards central pain processing problems in fibro being driven by peripheral nerve injury.
    Ecoclimber, Sea and alex3619 like this.

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