Invisible Illness Awareness Week 2016: Our Voices Need to Be Heard
Never heard of Invisible Illness Awareness Week? You're not alone. Jody Smith sheds a little light to make it more visible
Discuss the article on the Forums.

Larifan as an Ampligen alternative? Has this ever been tried in ME/CFS?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Jesse2233, May 7, 2017.

  1. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    In another thread @Jeremy C. put forward the idea that Ampligen's mechanism of action might be replicated by the interferon inducer Larifan. He shared a link, which contains the following summary.

    Unlike other Ampligen analogues Ridostin or Polyguacil, Larifan seems to be available for purchase.

    I'm curious if anyone knows whether or not Larifan has ever been used by an ME/CFS patient. I found no reference on PR or across the web other than @Hip and @heapsreal mentioning it in the context of other interferon inducers.

    I'm also curious on the thoughts of our scientifically minded posters on whether Larifan could actually approach Ampligen's demonstrated effectivensss for a certain post viral, high nRnase subset.

    ------

    This is my third post in a series on Ampligen.

    See: Update in Ampligen availability in the US
    And: What does Ampligen's effectiveness tell us in light of the latest research?

    I'm intrigued with Amplgien because of the plethora of stories touting its effectiveness and its frustrating elusiveness
     
    cigana, Binkie4, Jeremy C. and 4 others like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    8,882
    Likes:
    8,183
    australia (brisbane)
    Most of the research on many of these interferon inducers seem to be done in russia and the Ukraine. It would be good if some of the richer western countries would pursue this research but im not sure it would be in the area of cfsme treatments.

    I think if some can be diagnosed and treated for all their infections with the right avs and abx etc and i thing interferon inducers would help finish off these infections and then used to maintain a strong immune system.

    It seems that these interferon treatments are effective for those with enteroviruses going by Dr Chia's research. I think one of the main problems we have is that i dont think current medicine can even diagnose many chronic infections and i dont think they are that interested in doing so unfortunately. Its easier for them to diagnose some sort of mood disorder or generalized autoimmunity issue when they cant pin point the cause of someones symptoms .

    Ranting abit, but theres that strong relationship with interferon and natural killer cell function also.
     
  3. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    Yes I agree, would be good to get more interferon inducer research here.

    How does the mechanism of action of interferon-gamma / alpha (which Chia uses) compare with Larifan or Ampligen?
     
    Jeremy C. likes this.
  4. halcyon

    halcyon Senior Member

    Messages:
    2,297
    Likes:
    5,375
    The latter let the body control the rate of interferon release in response to the stimulus. With injectable recombinant interferon, you're not letting the body control anything, you're just flooding it with interferon it didn't produce. Several kinds are pegylated as well, which slows the breakdown of it, so it hangs around longer in the body than natural interferon does.
     
    heapsreal, Jeremy C. and Jesse2233 like this.
  5. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    Thanks Halycon, that's interesting. Is there a reason a physician would choose one kind over the other?
     
    Jeremy C. likes this.
  6. halcyon

    halcyon Senior Member

    Messages:
    2,297
    Likes:
    5,375
    I imagine the toxicity and side effects are probably lessened by using something like Ampligen, but I imagine the effects aren't as strong either. Interferon treatment can be pretty horrible from what I've read, though it also doesn't sound too different from what people with ME go through anyways.
     
  7. Jeremy C.

    Jeremy C.

    Messages:
    38
    Likes:
    127
    Melbourne, Australia
    Thanks for starting this post @Jesse2233. Definitely something I am interested in!

    Yes, I was very keen to try interferon with all the difficulties in accessing Ampligen, but the side effects can be pretty bad. The one I worry about is that it seems it can trigger autoimmune disease. Also terrible depression. There is one person with ME who has claimed success with low dose interferon, which is interesting. Another person on Phoenix Rising did not respond, but did not respond to Ampligen either.
     
    Jesse2233 likes this.
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    8,882
    Likes:
    8,183
    australia (brisbane)
    From what i have read about cycloferon, it mainly stimulates alpha and beta interferon which are said to be anti inflammatory, gamma interferon is said to be pro inflammatory so can make people feel worse which could be why many feel worse of certain interferons.

    Cycloferon and other interferon inducers were also used by russian drs after a patient had been through an interferon treatment course. Interferon treatments it seems can have a negative feedback mechanism so ones natural interferon can be much lower after IF treatments.

    I also wonder if this could be why dr chia has patients relapse after interferon treatments. I wonder if an appropriate IF inducer after interferon could help hold his treatment responders longer??

    Certain coinfections may need more then IF also to have a positive response??
     
  9. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    That's interesting. Have you ever tried any of the milder interferon inducers? Or even herbal interferon inducers like oxymatrine?

    I just remembered, Dr Chia told me that in some Hep C patients the use of interferon had actually induced ME/CFS. Not sure what to make of this
     
  10. Jeremy C.

    Jeremy C.

    Messages:
    38
    Likes:
    127
    Melbourne, Australia
    Not yet, but I have recently ordered some Cycloferon and Anaferon. My worry with these is that I have no idea how safe they really are, especially to take long-term.

    Is oxymatrine actually an interferon inducer? I was never sure whether Dr Chia was recommending it because it was an interferon inducer or because it had a direct action against enteroviruses
     
    Jesse2233 likes this.
  11. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    My understanding is both though I'm not sure. I will try to ask next time I see him
     
    Jeremy C. likes this.
  12. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    In your view, if one is a responder to Ampligen are they also likely to be a responder to interferon?
     
    Jeremy C. likes this.
  13. halcyon

    halcyon Senior Member

    Messages:
    2,297
    Likes:
    5,375
    Who knows? It seems like a reasonable assumption to me though.
     
    heapsreal and Jeremy C. like this.
  14. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    8,882
    Likes:
    8,183
    australia (brisbane)
    There seems to be a link between ms and cfs, how strong that link is, is debatable but ms pts are put on different interferons to help them. I dont think they really know how it helps ms. Theres are strong association with ebv and ms, theres also be some good results with ms pts using antiretrovirals.
     
    Jeremy C. and Jesse2233 like this.
  15. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,611
    Likes:
    4,027
    Southern California
    It seems using an interferon inducer along with oxymartine has synergistic effects.

    There's this 2016 study from China using the above combo to treat Chronic HVB
    And there's also Dr Chia's case study of putting his son in long term remission using the same combo.

    If interferon therapy is too difficult for many to tolerate, I wonder if a protocol combining Ampligen, Larifan, Ridostin, Polyguacil, or other Russian interferon inducers with oxymartine could be effective
     
    Jeremy C. likes this.

See more popular forum discussions.

Share This Page