Well.. I read the 2012 thread about autoimmunity and large pupils and found it interesting. I suffer from the saucer pupil problem, which triggers migraines and causes eye strain. I'm always looking for new solutions. Sunglasses in front of the computer don't help, because the eye just dilates further to compensate. I have found 2 things that help. 1) Alphagan P: This is an eyedrop that is like clonidine for the eyes. Huge reduction in pupil size in low light environment. Reduces glare while driving at night. Commonly used post-Lasik when people have the huge pupils (Lasik causes large pupils and dry eyes, among other things, by severing small-fiber nerves, thus partially denervating the eye. I suppose autoimmunity could do the same thing.). Can worsen fatigue. There is a special way to instill the drops so that they don't enter systemic absorption. 2) Bright full spectrum lights in front of the monitor facing my eyes. Since my eyes still respond to bright light, this helps them to constrict and reduce eye strain from the monitor. Light from the monitor, even with f.lux, seems much more likely to trigger a migraine so I try and minimize the light my eyes receive from the monitor and maximize it from other sources.