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"Landmark Analysis of an Infamous Medical Study Points Out the Challenges of Research Oversight"

Discussion in 'Other Health News and Research' started by Dolphin, Sep 17, 2015.

  1. Dolphin

    Dolphin Senior Member

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    This is on the original paper and now re-analysis of a trial of an antidepressant, paroxetine (Paxil, Seroxat, etc.), and why an increase of suicidality wasn't reported.

    It touches on a few different issues e.g.
    - re-analyses of trial data (still fairly rare)
    - the reporting of harms (adverse events)
    - retractions (not done in this case)
    - what punishments there should be for people who publish flawed papers.
     
    Last edited: Sep 17, 2015
    Sean, Snow Leopard, JaimeS and 8 others like this.
  2. Dolphin

    Dolphin Senior Member

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    BMJ editorial on the story:
     
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  3. Esther12

    Esther12 Senior Member

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    Two of the SMC's experts were pretty dismissive of this, but one said a lot of things relevent to PACE:

    http://www.sciencemediacentre.org/e...oxetine-in-adolescents-with-major-depression/
     
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  4. Simon

    Simon

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    Monmouth, UK
    Interesting stuff

    Landmark Analysis of an Infamous Medical Study Points Out the Challenges of Research Oversight
    another BMJ editorial on the subject: Liberating the data from clinical trials | The BMJ
    1. David Henry, professor1,
    2. Tiffany Fitzpatrick, meta-data specialist2

    The original blog closes with a caveat:
    Finally, the BMJ paper Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence
     
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  5. Dolphin

    Dolphin Senior Member

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    Here is the basic info about suicidality or self-harming which I didn't notice, or else can't remember, from the two articles I posted:


    From Guardian article: http://www.theguardian.com/science/2015/sep/16/seroxat-study-harmful-effects-young-people
     
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  6. Sean

    Sean Senior Member

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    Elephant. Room. Mote in one's own eye. Look into this mirror. Etc.
     
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  7. Dolphin

    Dolphin Senior Member

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