Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
Discuss the article on the Forums.

"Landmark Analysis of an Infamous Medical Study Points Out the Challenges of Research Oversight"

Discussion in 'Other Health News and Research' started by Dolphin, Sep 17, 2015.

  1. Dolphin

    Dolphin Senior Member

    Messages:
    10,689
    Likes:
    28,230
    This is on the original paper and now re-analysis of a trial of an antidepressant, paroxetine (Paxil, Seroxat, etc.), and why an increase of suicidality wasn't reported.

    It touches on a few different issues e.g.
    - re-analyses of trial data (still fairly rare)
    - the reporting of harms (adverse events)
    - retractions (not done in this case)
    - what punishments there should be for people who publish flawed papers.
     
    Last edited: Sep 17, 2015
    Sean, Snow Leopard, JaimeS and 8 others like this.
  2. Dolphin

    Dolphin Senior Member

    Messages:
    10,689
    Likes:
    28,230
    BMJ editorial on the story:
     
    JaimeS, alkt, ahmo and 4 others like this.
  3. Esther12

    Esther12 Senior Member

    Messages:
    8,449
    Likes:
    28,523
    Two of the SMC's experts were pretty dismissive of this, but one said a lot of things relevent to PACE:

    http://www.sciencemediacentre.org/e...oxetine-in-adolescents-with-major-depression/
     
    Woolie, Graham, Valentijn and 7 others like this.
  4. Simon

    Simon

    Messages:
    1,927
    Likes:
    14,578
    Monmouth, UK
    Interesting stuff

    Landmark Analysis of an Infamous Medical Study Points Out the Challenges of Research Oversight
    another BMJ editorial on the subject: Liberating the data from clinical trials | The BMJ
    1. David Henry, professor1,
    2. Tiffany Fitzpatrick, meta-data specialist2

    The original blog closes with a caveat:
    Finally, the BMJ paper Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence
     
    Woolie, Valentijn, Sea and 4 others like this.
  5. Dolphin

    Dolphin Senior Member

    Messages:
    10,689
    Likes:
    28,230
    Here is the basic info about suicidality or self-harming which I didn't notice, or else can't remember, from the two articles I posted:


    From Guardian article: http://www.theguardian.com/science/2015/sep/16/seroxat-study-harmful-effects-young-people
     
    Woolie, Valentijn, JaimeS and 5 others like this.
  6. Sean

    Sean Senior Member

    Messages:
    3,257
    Likes:
    17,985
    Elephant. Room. Mote in one's own eye. Look into this mirror. Etc.
     
    Woolie, Valentijn and SOC like this.
  7. Dolphin

    Dolphin Senior Member

    Messages:
    10,689
    Likes:
    28,230
    Sasha likes this.

See more popular forum discussions.

Share This Page