I think there is something to this. I have noticed that I seem to NEED tyrosine (an amino) in pill form to function like a human being (though I quit because I didn't want to Band-Aid the problem).....and guess what?!?! You need to break down the proteins you consume to get those aminos (people on PR who understand digestion know this, but those of us with only high school or basic college science may not recall that amino acids=proteins which need proteases to be broken down...I needed Wikipedia to make these connections). It took me awhile to figure out that anything with "L-" in front of it is an amino acid, unraveled in my STOMACH, and also other parts of the digestive system....requiring enzymes from various parts of my GI. I spent a day listing all the digestive enzymes I could find by name (and noting what exactly they break down, food-wise), even the weird/random ones, and trying to find a supplement that supplied basically every enzyme or covered every food substance. The closest I could find was Now's Digest Platinum. It had a few random enzymes I couldn't find elsewhere. Then I decided to "pad" that pill with Country Life's "Glutenzyme." Well, the Now supplement burned my stomach big time. The Country Life one doesn't seem to. Also, I noticed that Wobenzym contains the enzyme Trypsin, which I couldn't find in any digestive supplement, except one really pricey digestive one. From what I understand, Trypsin works in the small intestine, not the stomach, and it is sort of the "enzyme of last defense," when it comes to proteins/aminos from foods (and possibly supps?). In other words, it further breaks down those aminos. This is based on MY research, so I could be wrong. So I figured I should also take my Wobenzym with foods/supps. Note that I didn't read this whole thread, I am just spilling my thoughts here, because the original topic paralells what's been on my mind. Anyways, it seems that I have an obvious case of B12 deficiency, and am anemic by bloodwork, even though my iron is fine. Also, I don't seem to have enough collagen (my opinion), and other things I need from foods. So tackling absorption seemed like an obvious decision. I have done some decent diets, so to me, it seemed like this problem was deeper than some fancy elimination diet. That is what began my mini-fascination with enzymes. That, and my hair was getting very fine and wispy, and I figured the problem was absorption. I think it was/is due to vitamin deficiency. Another thing catching my attention is Intrinsic Factor. Read first two paragraphs here for its importance. http://en.wikipedia.org/wiki/Pernicious_anemia I.F. is something we all seem to need, yet I don't hear it talked about much here. So far I'm only really finding it in Metagenics' Intrinsi B12/Folate supplement. They say on that Wiki page that B12 shots are the Treatment, but wouldn't it be nice if we could address the real problem and take the I.F.? Because I'm just not sure the shots would really duplicate getting what we need from food. I did lots of B12 shots (methyl, high quality), and while they helped, they weren't a perfect solution....I became almost dependant on them, and it didn't feel like a full solution. From vitamins back to aminos...If I could just get some Tyrosine from food, not powdered, which makes me edgy, I'd be doing pretty good. Also, who among us doesn't need Seratonin and Melatonin, which come from our friend, L-Tryptophan? Taking the aminos in pill form never works out properly....I need my body to do this for me. So those are my thoughts. Enzymes to unlock everything.....and possibly taking this Intrinsic Factor. Would love to hear if anyone has brand recommendations for the enzymes and for the I.F, and any other thoughts. What proteases are you all taking, what brand? Need specifics. An how are you preventing them from hurting your stomach (I got BAD stomach cramps, so maybe too high dosage for my tiny tummy). Thanks.