Short version of my question: If I've been taking methyl b12 and metafolin for a week and noticed positive results, should I stop taking them and go get lab work done to confirm I have an issue (and see if I have any related issues, such as potassium deficiency)? If so, how long do I need stop taking them before the lab work? What specific lab work would be good to have done? Long version of my question: (if you are interested in my background) I've been trying to treat what my doctor calls "ADHD Primarily Inattentive" type. More accurately, all my symptoms fall under what is generally known as SCT (sluggish cognitive tempo) on the internet, but not yet recognized as a real thing by my doctor. After going through several trials of different drugs, mostly stimulants, I've settled on using Selegiline, a selective, type-B MAOI. It's working fairly decent with it's low side effects profile and subtle action. The fact that it reduces oxidative stress of the brain was a big selling point for me. However, I still have issues with lack of motivation, trouble getting out of bed, etc. The doctor has been doing his thing trying to figure out how to treat me as having ADHD-PI, but in the meantime I've been researching other possibilities on my own. My symptoms have a lot of overlap with b12 deficiency and CFS, so I've been researching them as well. I mentioned lab tests for vitamins/minerals/heavy metals before and was pretty much scoffed at since I am "in otherwise decent health", with a decent diet. He wanted to put me on antidepressants (SNRI's), but my serotonin system functions perfectly, so I never touched them. Why potentially create problems with something that isn't broken? I now have a new doctor who is open to different ideas, and isn't interested in pumping me full of amphetamines or potentially damaging mood enhancers. Recently, I decided to check into methylation related supplements (sam-e, methylcobalamin, TMG, and methylfolate), specifically in relation to their effects on COMT inhibition. I picked up a bottle of Jarrow's Sublingual 1mg Methylcobalamin. I will say this real quick: I have tried several medicines, supplements, herbs, etc. over the last year, trying to treat this. Very few have much effect on me (I'm apparently "immune" to the placebo effect). However, from the very first day I took the methyl b12, I felt... different. My body didn't ache as much. I felt more energetic, though I did feel a little bit "high on life," so to speak, with my head floating around in the clouds. After about 4 days of taking it twice a day, I started to not feel as much "floatey head" anymore. I also picked up some Solgar Folate 800mcg, NOW TMG, NOW potassium gluconate, and some SAM-e, and started taking them throughout the last couple days. I've already been taking Magnesium L-Threonate and Fish Oil, twice a day for months. I have plans to pick up some adenosyl b12 soon, after reading around on this forum. (EDIT: I just place an order for Jarrow's 5mg Methyl B12 Sublinguals and Source Naturals 10mg Dibencozide Sublinguals) In about 6 months, I will lose my current medical insurance coverage. Because of that, I need to prioritize what medical work I plan to have done. It would be nice to have some kind of confirmation via lab test to determine if I actually do have issues with B vitamins/methylation. I've had a few positive life changes lately, which could (very unlikely) account for the sudden "good times" effect (though I doubt it, since the physical and mental change was substantial when I first started taking the methyl b12). Since I have been taking the methyl b12 for about a week, does anyone have any recommendations how to proceed, such as: which tests to have done, if I should stop taking the vitamins for a certain period of time to get valid test result, etc...? I hate to get a bunch of lab work done and have the results come back negative just because I am taking the supplements. I don't know how long it would take to work them out of my system to get accurate numbers. Any input would be lovely. Thanks!