hi all, I feel like I'm posting a thread a day here, I'm also not sure if this is the right place to post this, but has anyone had any luck with l-histidine for the overmethylated bio type? Let me give you some background info: I have very low histamine, clinically tested. P5P was making me feel great for a while but nothing lasts forever, whenever I take p5p now it makes me foggy and disoriented! Anywho, I came to the conclusion that either 1)I have candida and b vits feed candida or 2)I have an oxalate issue. Blood tests and an upcoming stool test will tell me everything. A few days ago I picked up L-Histidine. I read somewhere that zinc and p5p were required in the conversion of l-histidine to histamine so this was a shot in the dark. To my surprise within a few minutes of taking it I felt on top of the world, as good and motivated as I used to feel when I took p5p. My logic was that p5p and my daily zinc intake of 44mg at the time was converting the histidine in my body into histamine, but that started to create a histidine deficit and the p5p was feeding my oxalate issue or candida instead. After reading up on L-Histidine, i learned its an important amino in the CBS mutation (which I also have), and that it scavenges nickel amongst other heavy metals. This might also be placebo but I woke up with clear sinuses and not as groggy as I'm used to, which is a step forward for me. So now I'm taking L-Histidine for 500mg and I ordered sublingual p5p for 25mg. Has anyone else had any luck with L-Histidine?