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Ku Shen-Sophora Flavescens-Oxymatrine

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Arise, Jul 24, 2017.

  1. Arise

    Arise

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    After reading about the potential of oxymatrine in ME/CFS, I decided to buy some Ku Shen Herbs from bristol botanicals (not the concentrated form). The way I take the herb is to boil it in water for about an hour and then strain the water into a cup and throw away the herb, then drink the water in the morning.

    So far I have not noticed any improvements but gives me diarrhea or more bowel movement in general. It is not a symptom that is associated with Ku Shen anywhere, so I was wondering if any one else experienced this or if I was doing something wrong.

    thanks
     
  2. Steve4Andrea

    Steve4Andrea

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    Just a guess but I think that the Oxymatrine would be extracted better in an ethanol or ethanol water solution. Often the important compounds of herbal treatments are not soluble in water and require ethanol to extract them. I make standard ethanol extracts by adding 100ml. of ethanol per 10 gr. of herb and then sealing in a jar and covering it in a water bath of about 170 deg. F. for several days (I use a small cooler to keep it in).

    Here is a link to a paper on using ethanol/water and microwaves to extract Oxymatrine- I've used the microwave assisted extraction technique before and I think it creates a better extract faster.

    http://www.mdpi.com/1420-3049/16/9/7391
     
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  3. Hip

    Hip Senior Member

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    The pure oxymatrine tablets and capsules that ME/CFS patients use contain around 200 to 300 mg of oxymatrine each, and these are taken several times a day, so over a day you might take a total of around 2 grams of oxymatrine.

    The normal Sophora flavescens root (Ku Shen) contains 2% oxymatrine, which means you would need to use 100 grams of the root each day (since 2% of 100 grams = 2 grams), in order to achieve the oxymatrine doses that are normally employed to treat ME/CFS.

    So you would need to use a lot of Sophora flavescens root to obtain your oxymatrine dose, which will work out to be quite expensive.

    The pure oxymatrine pills can be obtained here:

    Some Sources for Oxymatrine

    Equilibrant (Dr Chia's brand) oxymatrine tablets are available here.

    Alternative Medicine Solutions oxymatrine capsules containing 300 mg of oxymatrine powder per capsule are available here: 1, 2, 3, 4, 5.

    White Tiger brand oxymatrine tablets, containing 200 mg oxymatrine per tablet, can be found here: 1, 2, 3, 4, 5.

    Note that Dr Chia says oxymatrine is not recommended for people with autoimmune tendencies or seizure disorders.



    Note that there are a few things you need to know before embarking on an oxymatrine treatment for ME/CFS, so background reading is essential, and the following threads and articles may be a good place to start:

    Dr Chia: Oxymatrine, Oxymatrine, Autoimmunity, ME/CFS and FM, Quixotic: Equilibrant, Invest in ME 2010 conference transcript, oxymatrine effects, immunomodulators info.
     
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