I started on klonopin around 1998 and had my first bit of fatigue in 2005, a more significant bout of fatigue at the end of 2007, and chronic fatigue starting in September of 2009. Is there any evidence that klonopin can lead to chronic fatigue syndrome? Has anyone with cfs been on klonopin and had significant improvement after tapering off? About the only thing I can find on the net is klonopin as a treatment for cfs!