anciendaze
Senior Member
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By now you've heard many strange stories about odd behavior of different classes of immune cells, if you've been interested in following research on them, as I am. Here's a discovery made at University of Michigan about cancer therapy which reveals why previous theories of immune activity which showed that T-reg cells were limiting immunotherapy against cancer cells failed to improve matters.
If T-regs are preventing therapy, we'll just kill them off, right? Instead, things got worse, because dying T-regs signaled to cause even more inhibition of immune activity.
Why am I posting this here? The signals came from dying cells releasing ATP, purinergic signalling. What else does ATP do? Well, it is sort of important in energy production (metabolism).
We have another link here between dysfunctional immune regulation and metabolomics.
If T-regs are preventing therapy, we'll just kill them off, right? Instead, things got worse, because dying T-regs signaled to cause even more inhibition of immune activity.
Why am I posting this here? The signals came from dying cells releasing ATP, purinergic signalling. What else does ATP do? Well, it is sort of important in energy production (metabolism).
We have another link here between dysfunctional immune regulation and metabolomics.