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Ketotifen for leaky gut

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by hixxy, Mar 11, 2012.

  1. mellster

    mellster Marco

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    Thanks Rusty - very interesting! My testosterone was at the low end of the ref range last year before supplementing (IGF1 was normal to low normal though), and I def had symptoms of increased TNF-alpha. Wondering if it was this correlation. One thing I never understood about this though is that most have low basal temp and TNF-alpha is an important cytokine that is usually produced during fevers if I remember correctly. How do we produce it without fever? :)
  2. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Ketotifen seems to tick quite a few boxes for me, but I'm not convinced it's the bottom line cause. Haven't read anyone saying it's cured them. May depend on degree of damage to digestion coupled with vitamin deficiency (if that is a possible cause). But they have reported energy gains, weight gains, easing of food intolerances. I am already taking antihistamines (claratyne) for my eyes. I got an immediate improvement within a day, after 6 months of misery.
  3. mellster

    mellster Marco

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    Yeah, one thing I don't need anymore now that my digestion has at least improved to a workable level again is weight gain ;) Actually trying to lose some.. cheers
  4. hixxy

    hixxy Woof woof

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    Just reporting back my experience with this company. All went really well. The delivered product was Iodoquinol manufactured by Pfizer in mexico.I will likely use them again if need be.
  5. maryb

    maryb iherb code TAK122

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    Anyone tried it yet for leaky gut? Am thinking of asking my doc to prescribe it if it seems to work.
  6. gracenote

    gracenote All shall be well . . .

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    My doctor prescribed Ketotifen for leaky gut. I've been taking it for about 4 months now. I don't know what it's doing for my gut, but it is helping with sleep. I need to take it about 3 hours before I want to sleep and I sleep better and in longer chuncks. I still take Ambien, but I was able to cut down from almost 20 mg per night to 10. Some days I am groggy in the mornings.

    I take 1 mg of Ketotifen each evening. I get it by prescription from Clark's Pharmacy in Bellevue, Washington. They say it is a compounded prescription.
  7. Aileen

    Aileen Senior Member

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    I am seeing my doc later this week. Am going to ask her to prescribe it for me. Any suggestions as to what papers to take with me. She is very busy and has little time to read so it has to be short.
  8. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Hey hixxy, did your order turn up OK?
  9. Dainty

    Dainty Senior Member

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    My food issues are severe; one average I can eat about 5 foods total, and that's including coconut oil as a food.

    Several years ago I was prescribed compounded Ketotifen for leaky gut to take with every meal (up to 6 times a day). It seems it made a minor difference with food sensitivities - that was back when my ability to eat was extremely unstable and often limited to one or two foods, or no foods at all. Some time after my diet stabilized to the few foods I've been on for the past several years, I tested the difference the Ketotifen made and could not discern anything noticeable, so I stopped taking it regularly.

    I still keep it on hand as an option for when I'm reacting to something I ate, however since I generally try it alongside other things (such heparin injections, Loratadine, and activated carbon [i.e. charcoal]) I cannot be certain of how much it helps.
  10. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Hi Aileen. Did you end up getting ketotifen?
  11. Aileen

    Aileen Senior Member

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    No I didn't. Had to have some tests first which took months, now have a reactivating virus ... Not sure what to do about it now. I have tried some Claritin which doesn't seem to help and also cromolyn sodium nasal and that made things worse (both OTC) so now I'm not sure if a mast cell/histamine drug would help me. Sorry I can't be of help.
  12. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Aileen you could try the Clarintin eye drops, that and some other brands contain ketotifen (different formula to allergy tabs, check label), albeit in a lower dosage. Just means you have to take it quite a few times a day.

    I ended up ordering ketotifen from hixxy's mex drug supplier (but not much info about product), but just found another, perhaps more legit supplier, as it's the original Zaditen, although you will need a script:

    http://www.masters-uk.com/medicines/product.php?productid=1716&cat=0&page=1

    http://www.masters-uk.com/medicines/home.php?cat=14&sort=orderby&sort_direction=0&page=2
  13. redrachel76

    redrachel76 Senior Member

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    I've managed to get some from my GP and taken one tablet a day for 2 days.
    During those 2 days I have had had more brain fog than usual but I don't know if it from the Ketotifen or if I would have been brainfogged those 2 days anyway.
    I noticed no difference in digestive problems or food allergies in 2 days.

    How have others done?

    I stopped it today because I am starting hydrotherapy tomorrow and I want to see if that will help me and don't want interference from the ketotifen drug, just in case it is a brain fog increaser.

    The only positive thing so far is that unlike other antihistimines, it hasn't made my stomach problems worse.
    I'll try to remember to report back once I restart it. How is everyone else doing?
    Hanna likes this.
  14. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Initially, despite also taking antihistamines, I had a slight increase in reactions, which may well be the as a result of taking the keto.

    I think it takes at least 4 weeks for improvement.

    I am not sure whether you are on antihistamines. I have read that it is necessary that you continue to take h1, h2 antagonists such as zyrtec and ranitidine: these work hand in hand with the mast cell stabilizers such as keto and nexium. Nexium, as a mast cell stabilizer (h2) would have a greater impact in the short-term on digestion, but again, it is advised that this is done in conjunction with ranitidine or other h2 antagonist.

    As I understand it: h1= eyes and sinus, etc; h2=stomach, digestion

    Both need to be addressed at the same time, both by antihistamines and by mast cell stabilizers to prevent the feedback loops occurring.
    Hanna likes this.
  15. redrachel76

    redrachel76 Senior Member

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    No I am not on any other antihistamines.

    I just decided to take this alone for leaky gut to see if it helps my gut problems.
    All this thread was about taking only ketotifin alone until your post.

    I am confused now:confused: .

    Can't Ketotifin work alone for stomach and digestion?
  16. FunkOdyssey

    FunkOdyssey Senior Member

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    I think we have some mastocytosis treatment guidelines influencing the dialogue here with the multi-drug antihistamine cocktails. Fact is, ketotifen alone is used to treat leaky gut (see: http://www.collegepharmacy.com/images/download/Woeller_Ketotifen_Protocol.pdf) and ketotifen alone is clinically proven to be helpful for IBS:

    Ketotifen is a very powerful H1 antagonist so the idea of an additional H1 antagonist seems redundant anyway. If you want more H1 antagonism, why wouldn't you simply take more ketotifen?

    And H2 antagonism isn't something to play with lightly. You depend on normal levels of stomach acid to ward off gut infections, as well as absorb a variety of nutrients. The last thing I want to do is impair my digestive processes, leave more undigested protein to stimulate food sensitivities and allergies, and allow my gut flora to become even more deranged. If it is clearly helping someone I wouldn't tell them to stop, but if you're just experimenting to test an unproven MCAS theory of CFS, weigh the risks/benefits carefully.
    redrachel76 likes this.
  17. FunkOdyssey

    FunkOdyssey Senior Member

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  18. FunkOdyssey

    FunkOdyssey Senior Member

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    For anyone trying ketotifen, remember that it is an older antihistamine with good BBB penetration, unlike the newer drugs which are designed not to enter the brain. This means you're going to feel some sedation and impairment of cognition when you begin. I get really frustrated when this discourages people from continuing though, because it is temporary:

    H1 receptors in the CNS rapidly adapt to practically any dose and strength of H1 antagonism and restore homeostasis (aka baseline levels of alertness and cognition). Give it a week before drawing any conclusions.
  19. searcher

    searcher

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    Do you know if ketotifen effects acetylcholine FunkOdyssey? What always concerns me about benadryl is the research showing that it is associated with Alzheimer's and cognitive impairment in seniors. Theoretically this is because of its anti-cholinergic function. http://well.blogs.nytimes.com/2012/02/27/cocktail-of-popular-drugs-may-cloud-brain/ is a good article discussig the link. I still take benadryl for sleep sometimes and hope this is only a problem for seniors, but I get nervous about potentially increasing cognitive dysfunction.
  20. FunkOdyssey

    FunkOdyssey Senior Member

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    I don't know for sure but the side effect profile looks like pure H1 antagonism to me (drowsiness, weight gain, irritability, dry mouth). If you look at a typical anticholinergic drug like diphenhydramine the list of sides is about 5x longer and includes scary cardiac stuff, urinary retention, constipation, etc.
    searcher likes this.

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