Thanks Rusty - very interesting! My testosterone was at the low end of the ref range last year before supplementing (IGF1 was normal to low normal though), and I def had symptoms of increased TNF-alpha. Wondering if it was this correlation. One thing I never understood about this though is that most have low basal temp and TNF-alpha is an important cytokine that is usually produced during fevers if I remember correctly. How do we produce it without fever?