? Methylation Block
You implied that if you had a methylation block it should have probably lifted in the 3 years of treatment, but I went through very similar things with my daughter and many others have with their kids and loved ones also. It sounds as though you are treating very specific issues and from my understanding (Now that Freddd & Rich explained the differences in the folates, folinic, and 5MTH), the supplements your using are targeting MTHFR, MTR, etc., type defects but you likely have others that are not being addressed at all. I can't say that I understand the pathway so well that I could predict which defects wouldn't respond to those sorts of treatments and then guess at yours but I do know that the SUOX causes heartburn/acid issues as well as asthma like symptoms or chest tightness and shortness of breath and it responds to the methyl b12 as well as curtailing your sulfur supplements and foods & taking Molydbenum (my daughter has this defect). There are many more that can also be a big problem but have specific ways to get around them so please don't discount the testing. If you can ever afford it, its worth its weight in gold. My doctor and I were able to get to the root of my daughter's issues and fully recover her from autism and CVID, an immune problem, and I know of many others who are on the road to full recovery by knowing their genetics. It sure isn't the answer for everything in life but it is a good start at solving your specific issues rather than just guessing as we all had to do before this option came to light.
As for the COMT ++ issue, I can tell you that this defect has a lot to do with the VDR Taq and the two work together to sorta create your methyl donor tolerance. My daughter is ++ but since her VDR TAQ is ++ & not working, its like she's more balanced as a COMT +- instead and can handle a little more of them than she could of otherwise. She still has some mood fluctuations since I guess you're still likely to have the dopamine shifts when this area affects the balance there but the methyl donor tolerance is definitely not the same. I don't know as much about the VDR-- issue but I'd expect those combo's would be the worst for methyl donor tolerance and it seems like these are the ones that would be the overmethylators. I guess nothing is ever simple with Dr. Yasko's stuff since you can't really go by the COMT alone.
Good luck with your treatment, I hope you find what works for your health!
Angela