Hello! So here are some 23&me results just in. I see some contradictions, so I don’t know how to deconstruct the data. If any of you have any input, that would be so swell. THANK YOU (I feel a bit less CFSy on 2 days of a lot of methylfolate, charcoal, & extra b12!) Mutations detected: C282Y, H63D rs1799945 H63D C to G CG i3002468 S65C A to T AA I think that means high levels of homocysteine. “According to Dr. Ben Lynch, impaired function of the enzyme can cause or contribute to conditions such as… Chronic Fatigue Syndrome…” (‘ya think?) Hemochromatosis? Iron overload, though rare, or “mild” if have these 2 mutations together, I guess. Well, something is clearly not “mild” in my CFS. Other results: * SNP: rs1801133 (A or G) * Anon's Genotype: AA * Gene: MTHFR * Chromosome: 1 * SNP: rs1801131 (G or T) * Anon's Genotype: TT * Gene: MTHFR * Chromosome: 1 You have 0 homozygous (+/+) mutations and 5 heterozygous (+/-) mutations. Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR): * VDR Bsm * VDR Taq * MTRR A66G * CBS C699T * CBS A360A “CBS defects are actually upregulations. This means the enzyme works too fast. In these patients, it's common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine.” HUH? Aren’t I supposed to already have too high homocysteine? So do these two factors then cancel each other out, so it means my homo. Is fine? “This leads to high levels of taurine and ammonia. If taurine climbs one may need to address ammonia. Yucca Root and Charcoal/Magnesium flushes can help address high ammonia levels. High doses of L-Ornithine may be effective as well according to medical studies. The CBS mutation not only leads to excess taurine, but can also lead to excess sulfur groups. There are many things one may need to avoid with a CBS upregulation. Some of the items include garlic, broccoli, eggs, onions, legumes, meat, Epsom salt baths, alpha lipoic acid, glutathione, chelating agents such as DMPS, NAC, Milk Thistle, various other supplements, and much more.” (No beans? Like that's going to happen. I'm a vegetarian.) COMT V158M rs4680 GG -/- (I think means increased dopamine, not a bad thing, right?) COMT H62H rs4633 CC -/- COMT P199P rs769224 GG -/- GSTP1 I105V rs1695 AG +/- GSTP1 A114V rs1138272 CT +/- GSTT1 Absent* (23 doesn’t test for this) “Methyl B12 is usually much easier to tolerate for those that are COMT (-/-). Patients with MTR/MTRR may also benefit from the combination of GABA and L-Theanine. L-Theanine is a methyl donor. They may also benefit from taurine, Pycnogenol® pine bark extract, and grape seed extract.” HUH? Am I not too high in taurine already? >>face palm “With COMT V158M + and a VDR Taq + status, the body may have further trouble tolerating methyl donors.” Another contradiction… aren’t I supposed to tolerate methyl group best? Methylation Analysis Results Gene & Variation rsID Alleles Result COMT V158M rs4680 GG -/- COMT H62H rs4633 CC -/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO A R297R rs6323 GG -/- ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AA +/+ MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 AG +/- MTRR H595Y rs10380 CC -/- MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 CC -/- MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CC -/- BHMT-04 rs617219 AA -/- BHMT-08 rs651852 CC -/- AHCY-01 rs819147 TT -/- AHCY-02 rs819134 AA -/- AHCY-19 rs819171 TT -/- CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/- CBS N212N rs2298758 GG -/- SHMT1 C1420T rs1979277 GG -/- Gene & Variation rsID Alleles Result CYP1A1*2C A4889G rs1048943 TT -/- CYP1A1 m3 T3205C rs4986883 TT -/- CYP1A1 C2453A rs1799814 GG -/- CYP1A2 164A>C rs762551 CC +/+ CYP1B1 L432V rs1056836 CG +/- CYP1B1 N453S rs1800440 TT -/- CYP1B1 R48G rs10012 CG +/- CYP2A6*2 1799T>A rs1801272 AA -/- CYP2A6*20 rs28399444 II -/- CYP2C9*2 C430T rs1799853 CT +/- CYP2C9*3 A1075C rs1057910 AA -/- CYP2C19*17 rs12248560 CC -/- CYP2D6 S486T rs1135840 CG +/- CYP2D6 100C>T rs1065852 GG -/- CYP2D6 2850C>T rs16947 AG +/- CYP2E1*1B 9896C>G rs2070676 CC -/- CYP2E1*1B 10023G>A rs55897648 GG -/- CYP2E1*4 4768G>A rs6413419 GG -/- CYP3A4*1B rs2740574 TT -/- CYP3A4*2 S222P rs55785340 AA -/- CYP3A4*3 M445T rs4986910 AA -/- CYP3A4*16 T185S rs12721627 GG -/- GSTP1 I105V rs1695 AG +/- GSTP1 A114V rs1138272 CT +/- SOD2 A16V rs4880 AG +/- NAT1 R187Q rs4986782 GG -/- NAT1 R64W rs1805158 CC -/- NAT2 I114T rs1801280 CT +/- NAT2 R197Q rs1799930 AG +/- NAT2 G286E rs1799931 GG -/- NAT2 R64Q rs1801279 GG -/- NAT2 K268R rs1208 AG +/- Also also said I have Alpha-1 Antitrypsin Deficiency. Lastly, for fun, my supposed increased risk of these: Compared to Average Venous Thromboembolism Established Research: Multiple studies with 750+ participants 35.4% 9.7% 3.63x Woo hoo! (I have Factor V Leiden blood disorder so no surprise there) Atrial Fibrillation Established Research: Multiple studies with 750+ participants 20.5% 15.9% 1.29x Rheumatoid Arthritis Established Research: Multiple studies with 750+ participants 8.6% 4.2% 2.03x Parkinson's Disease Established Research: Multiple studies with 750+ participants 2.0% 1.6% 1.26x Much appreciation if anyone responds.