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Just another 23andme here....

Discussion in 'Genetic Testing and SNPs' started by Shrimpbones, Oct 31, 2017.

  1. Shrimpbones

    Shrimpbones

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    USA
    Hi all - I came here a while ago when my toes first started to go numb. It's been a while but now I'm back. After several b12 checks coming back low and a host of symptoms I finally decided on 23andme. So, I did that and then ran the raw data through Genetic Genie and Prometheas.

    Homozygous:
    MTHFR C677T ****************
    MTRR A66G
    CBS C699T
    CYP1B1 L432V
    NAT2 R197Q

    Heterozygous:
    COMT V158COMT H62H
    VDR Bsm
    VDR Taq
    BHMT-02
    SHMT1 C1420T

    So, the MTHFR is self-explanatory. Does anyone have any input on the rest? I am going to start Methylfolate tomorrow along with Methyl B12 (low and slow). I started and stopped MB12 numerous times - now realizing I probably needed the folate as well. I already take Magnesium daily and do fine with that. I have a question about potassium. The pills are 99mg? Several a day is required? Could I just drink a low-salt V8 or a large Coconut Water which each has over 1,000mg. Is it the same? Even with the smallest amount of B12 I always felt that I needed alot of potassium but it could have been folate that was needed. Also, I tried MB12, Hydoxy B12, and Adenosyl b12. All have had there own negative effects. I think I did feel best though with the MB12 for a while. I know it's trial and error but some guidance would be helpful. And does anyone experience shortness of breath with these mutations? I think that's driving me crazy the most. And, am I missing any supplements as I don't react well to many? Sorry about all the questions! I am reading and learning as much as I can.
     
  2. pattismith

    pattismith Senior Member

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    @Shrimpbones
    I may not be helpful to you unfortunately, so I hope others will comment your results.

    Like you I am homozygous for MTHFR C677T....But I did not well with methylation protocol.

    For the moment only hydroxyB12 injections suit me.

    I would just add that if you have some reason to suspect mitochondria disorder, ENLIS may be better to help you to browse your raw datas and find any missense mutation in your mitochondrial DNA.
     
  3. CedarHome

    CedarHome

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    Hi, @Shrimpbones
    I did not find MTHFR to be self-explanatory but glad it's not completely new to you.

    Personally, I bought a big container of potassium gluconate powder and add it 1/2 and 1/2 with table salt to water, along with some lemon or lime juice. If that seems too salty and I need the potassium alone, I just take it in water.

    I also have coconut water but sometimes that seems too sweet. I also have some v-8 type stuff and that's good to switch it up.

    there is a lot of great info here on Phoenix Rising about methylation & recommended co-factors.

    Possibly you've already seen the classic, :), @caledonia's Methylation 101?
    http://forums.phoenixrising.me/index.php?entries/caledonias-methylation-and-mercury-links.1744/

    And here's just a couple more

    here's one thread on micronutrient depletion
    http://forums.phoenixrising.me/index.php?threads/what-does-high-b12-mean.52890/

    http://forums.phoenixrising.me/inde...tion-protocols-trial-items.14637/#post-240482

    http://forums.phoenixrising.me/index.php?threads/methyl-folate-severe-crash.53368/#post-885970

    Good luck and keep us posted on how it goes!
     
    parpar likes this.
  4. Shrimpbones

    Shrimpbones

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    USA
    Hey, @CedarHome
    Thanks for the reply. I did by no means mean that MTHFR was understandable. Not at all - otherwise I would not be on this forum asking away. Just that I already knew what it meant because that is what I was specifically looking for. My B12 was already low and I wanted to see if a MTHFR mutation could be a possible contributing factor to that. Now that I have my results and also see some other mutations I am going to go to a genetic professional to help me sort this out and put all the pieces together. I was going to start MethylFolate but after doing some research I read that it should not be used if there is also a CBS mutation - that it could be dangerous. Not sure how true this is that is why I am seeking out a professional. I am somewhat fearful to self-medicate as the even the smallest amount of anything give me not so pleasant reactions. Thanks for all the info - I sure do need it!
     
    CedarHome likes this.
  5. CedarHome

    CedarHome

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    @Shrimpbones, There are conversations on PE about CBS as well.

    Really glad you're finding find. Good luck and please keep us posted!
     

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