Hi all - I came here a while ago when my toes first started to go numb. It's been a while but now I'm back. After several b12 checks coming back low and a host of symptoms I finally decided on 23andme. So, I did that and then ran the raw data through Genetic Genie and Prometheas. Homozygous: MTHFR C677T **************** MTRR A66G CBS C699T CYP1B1 L432V NAT2 R197Q Heterozygous: COMT V158COMT H62H VDR Bsm VDR Taq BHMT-02 SHMT1 C1420T So, the MTHFR is self-explanatory. Does anyone have any input on the rest? I am going to start Methylfolate tomorrow along with Methyl B12 (low and slow). I started and stopped MB12 numerous times - now realizing I probably needed the folate as well. I already take Magnesium daily and do fine with that. I have a question about potassium. The pills are 99mg? Several a day is required? Could I just drink a low-salt V8 or a large Coconut Water which each has over 1,000mg. Is it the same? Even with the smallest amount of B12 I always felt that I needed alot of potassium but it could have been folate that was needed. Also, I tried MB12, Hydoxy B12, and Adenosyl b12. All have had there own negative effects. I think I did feel best though with the MB12 for a while. I know it's trial and error but some guidance would be helpful. And does anyone experience shortness of breath with these mutations? I think that's driving me crazy the most. And, am I missing any supplements as I don't react well to many? Sorry about all the questions! I am reading and learning as much as I can.