Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Jason/DePaul: The implications of using a broad versus narrow set of criteria in research

Discussion in 'Latest ME/CFS Research' started by mango, Jun 25, 2017.

  1. mango

    mango Senior Member

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    The implications of using a broad versus narrow set of criteria in research

    Leonard A. Jason, Kristen Gleason, Pamela Fox

    Journal of Medicine and Therapeutics, 1(2), 1-6. doi: 10.15761/JMT.1000111

    Abstract
    The Fukuda et al. criteria is the most widely used clinical case definition for diagnosing patients with chronic fatigue syndrome (CFS).

    Despite the frequency with which the Fukuda criteria are applied, the list of symptoms outlined in this case definition were not well enough specified to be easily applied to research settings.

    In 2005, Reeves et al. laid out a set of standards for operationalizing the Fukuda definition, specifying scales and cutoff scores for measuring the symptom criteria. This operationalization, often known as the empirical criteria, has been shown to identify an unexpectedly large number of patients, seemingly widening the net of inclusion for CFS diagnostic criteria.

    However, in a recent study in 2016 by Unger and colleagues it has been suggested that the 2005 Reeves et al. 2005 operationalization of the Fukuda criteria does not over-identify the number of patients with CFS as had been previously reported.

    This article reviews prior studies which provide context for these findings and offers a possible explanation for the discrepancies.

    Clearly, determining what case definition to use and how to operationalize it remains an important activity for scientists in this field, as it will influence work in multiple domains, including etiology, pathophysiology, epidemiology and treatment.

    Key words
    chronic fatigue syndrome, epidemiology, case definitions

    https://oatext.com/the-implications...arrow-set-of-criteria-in-research.php#Article
     
  2. Tom Kindlon

    Tom Kindlon Senior Member

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    A lot of this paper is about the CDC's empiric criteria (Reeves et al 2005) and this particular study:
    Here is a comment I previously wrote on this study:

     
    Valentijn likes this.
  3. Tom Kindlon

    Tom Kindlon Senior Member

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    From the current paper:
     
  4. Tom Kindlon

    Tom Kindlon Senior Member

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    Good point I thought:
     
    Mel9, Valentijn and Esther12 like this.

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