Hunting down the cause of ME/CFS & other challenging disorders - Lipkin in London
In a talk to patients in London on 3rd September, Dr. W. Ian Lipkin described the extraordinary lengths he and his team are prepared to go to in order to track down the source of an illness, with examples ranging from autism to the strange case of Kawasaki disease.
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Jason 2010: Kindling and Oxidative Stress as Contributors to ME/CFS

Discussion in 'Latest ME/CFS Research' started by shrewsbury, Mar 12, 2010.

  1. shrewsbury

    shrewsbury member

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    Fred Springfield posted this to co-cure today

    (if: my bolds and spacing)

    Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Journal: Journal of Behavioral and Neuroscience Research, 2009, Vo1. 7, 1-17

    AuthorsL L. A. Jason [1, *], N. Porter [1], J. Herrington [1], M. Sorenson [1], & S. Kubow [2]

    Affiliations:
    [1] DePaul University and
    [2] McGill University
    [*] Corresponding author: DePaul University, Center for Community Research, 990 W. Fullerton Ave., Chicago, Il. 60614.

    Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) is one of the more complex illnesses involving multiple systems within the body. Onset of ME/CFS frequently occurs quickly, and many patients report a prior exposure to a viral infection. This debilitating illness can affect
    the immune​
    neuroendocrine​
    autonomic,​
    and neurologic systems. ​


    Abnormal biological findings among some patients have included
    aberrant ion transport and ion channel activity, ​
    cortisol deficiency, ​
    sympathetic nervous system hyperactivity, ​
    EEG spike waves, ​
    left ventricular dysfunction in the heart, ​
    low natural killer cell cytotoxicity, ​
    and a shift from Th1 to Th2 cytokines. ​

    We propose that the kindling and oxidative stress theories provide a heuristic template for better understanding the at times conflicting findings regarding the etiology and pathophysiology of this illness.

    Key Terms: Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Kindling, Oxidative Stress

    [Note: The full text of this article is available for free in PDF at
    http://strose.edu/academics/academi...roscienceresearch/journalcontents/article3255
    -
     
  2. Dolphin

    Dolphin Senior Member

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    Interesting paper.

    I found some of the reviews of areas useful e.g. neurology where I can get confused or have difficulty keeping up with the results.

    A couple of small corrections/points:
    (I) Technically, although de Lange et al (2008) claimed their study showed that CBT increases grey matter volume, they did not have a CFS control group so the results could simply be due to the passage of time in people with CFS (there might be a big drop at the start of the illness and then the brain gradually recovers). Two letters making this point were published (Bramsen, 2009 and Kindlon, 2009).

    (II) Vollmer-Conna (2008): they do not explain well what was found in the study. This study related to cytokine polymorphisms (i.e. genetic/inherited factors) but they don't say this. Here is the abstract of the study:

     

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