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Jamie Deckoff-Jones MD Report On Meds

Discussion in 'XMRV Testing, Treatment and Transmission' started by shannah, May 3, 2010.

  1. natasa778

    natasa778 Senior Member

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    Ethn Dis. 2010 Winter;20(1 Suppl 1):S1-163-7.

    The morbidity and mortality associated with kidney disease in an HIV-infected cohort in Puerto Rico.

    Mayor AM, Dworkin M, Quesada L, Ros-Olivares E, Hunter-Mellado RF. Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Puerto Rico. amayorb@hotmail.com
    Abstract

    INTRODUCTION: Nephropathy in HIV-infected patients has been associated with progression to AIDS and death. The virus, several comorbid conditions and certain medications may contribute to the development and progression of kidney disease. METHODS: This study analyzed data collected from HIV-infected persons enrolled in a HIV registry in Puerto Rico during January 1998 through September 2006. Demographic factors, clinical manifestations, laboratory findings at enrollment, and antiretroviral therapy (ART) prescriptions were compared between patients with and without kidney disease. Death status and cause of death by December 2006 were also evaluated and compared. RESULTS: The study included 1,283 subjects, 69.0% male, 39.7% injecting drug users, 19.5% hepatitis C infected, 6.5% with diabetes mellitus (DM-2), 11.6% had hypertension (HTN) and 9.0% had kidney disease. Patients with kidney disease had significantly higher (P < .05) HIV viral load mean (273,499 vs. 202,858 copies/mL), CD4 T-cell count < 200 (57.0% vs. 44.4%), underweight (22.9% vs. 10.9%), DM-2 (13.9% vs. 5.8%), HTN (27.8% vs 10.0%) and mortality (15.9 vs 5.7 deaths per 100 years of follow-up) than those without it. Cox proportional hazard analysis showed that patients with kidney disease had a higher mortality risk (2.1) after controlling for age, sex, HIV risk factor, ART prescription in the last year and HIV disease duration. CONCLUSIONS: This study demonstrated a substantial disparity in mortality for Puerto Rican HIV-infected patients with nephropathy. Kidney disease preventive strategies that include aggressive control of HIV-infection and chronic medical conditions, such as hypertension and diabetes, are recommend as an approach to reduce this health disparity. PMID: 20521408
     
  2. natasa778

    natasa778 Senior Member

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    Retroviral infection and kidney failure

    Cell. 1990 Aug 10;62(3):425-34.

    Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.

    Weiher H, Noda T, Gray DA, Sharpe AH, Jaenisch R. Whitehead Institute, Massachusetts Institute of Technology, Cambridge 02142.
    Transgenic mouse strains carrying proviruses were generated by exposing mouse embryos to a recombinant retrovirus. Animals carrying a single provirus were intercrossed to derive mice homozygous for a given proviral insertion. Adult mice homozygous for the Mpv17 integration developed nephrotic syndrome and chronic renal failure. Histologically, affected kidneys showed progressive glomerular sclerosis. Similar lesions are seen in patients with progressive renal function deterioration. A probe to DNA sequences flanking the provirus detected a 1.7 kb RNA ubiquitously expressed during embryogenesis and in adults with high levels in kidney, brain, and heart. This RNA was not detected in tissues of homozygous animals, suggesting that the provirus interferes with RNA expression. Sequence analysis of the cDNA revealed that the gene encodes a 176 amino acid peptide containing hydrophobic regions, suggesting membrane association of the putative protein. The Mpv17 mutant is a potentially useful experimental system for studying mechanisms leading to renal disorders in man. PMID: 1696177


    HIV-related kidney failure (from before the wide-spread use of antiretrovirals, ie the virus solely responsible)

    Klin Wochenschr. 1989 Sep 1;67(17):889-94.

    Acquired immunodeficiency syndrome (AIDS)--related renal disease.

    Bourgoignie JJ. Department of Medicine, University of Miami School of Medicine, Florida.
    More than 87,000 patients with acquired immunodeficiency syndrome (AIDS) were reported to the Centers for Disease Control in the United States, of whom more than half died through January 1989. When the AIDS epidemic is considered worldwide, these numbers should be doubled at least [27]. Whereas electrolyte disorders and acute renal complications were recognized early on in the AIDS epidemic, it was not until 1984 that a nephropathy was described in patients with human immunodeficiency virus-Type 1 (HIV-1) (formerly called LAV/HTLV-III) infection [18, 30, 36]. This nephropathy was characterized, clinically, by heavy proteinuria or the nephrotic syndrome and a rapid progression to end-stage chronic renal failure and, pathologically, by an aggressive form of focal segmental glomerulosclerosis. The existence of an AIDS-related nephropathy was not readily accepted because of its uneven geographic distribution amongst areas severely affected by the AIDS epidemic [24, 48]. This brief review summarizes the clinical and pathologic features of AIDS-related nephropathy. PMID: 2681968


    Am J Nephrol. 1992;12(5):281-7.

    Glomerular disease and human immunodeficiency virus infection in Brazil.

    Lopes GS, Marques LP, Rioja LS, Basilio-de-Oliveira CA, Oliveira AV, Nery AC, Santos Oda R. Department of General Medicine, School of Medicine and Surgery, University of Rio de Janeiro, Brazil.
    Clinically overt glomerular disease was detected in 6 (1.1%) of 543 patients with HIV infection followed at a Brazilian National Referral Center for AIDS. In 4 cases, glomerulosclerosis was present (focal and segmental in 3, diffuse and global in 1) and rapid progression to terminal renal failure was observed 1-10 months after clinical presentation. The other 2 patients died with normal renal function, and autopsy studies suggested the diagnosis of minimal change disease. Clinically overt glomerular disease was significantly more common among Black patients, whether all the cases with glomerulopathy (p < 0.001) or just the cases with glomerular sclerosis were considered (p = 0.011). Autopsy study of renal fragments from patients without clinical evidence of glomerular disease was additionally performed and revealed the presence of focal and segmental glomerulosclerosis in 3 cases (7.5%). We concluded that a glomerulopathy with clinicopathological features which match the definition of HIV nephropathy can be found among Brazilian patients with HIV infection. Accordingly to what has been described in American series, Brazilian Black patients seem to be at increased risk of the development of that nephropathy. PMID: 148899


    this is intriguing considering that aggressive form prostate cancer is much more prevalent in black men… ?


    Semin Nephrol. 1998 Jul;18(4):373-7.

    The human immunodeficiency virus (HIV) epidemic and HIV-associated nephropathy.

    Winston JA, Burns GC, Klotman PE.Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA.
    Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN), the single most common cause of end-stage renal failure in seropositive patients, has increased in incidence by 30% each year since 1991. Occurring almost exclusively in blacks, HIVAN became the third leading cause of ESRD in blacks, ages 20 to 64, in 1995. During that year, the absolute number of new acquired immune deficiency syndrome (AIDS) cases declined for the first time since the epidemic began. The decrease occurred predominantly in white males, whereas in blacks with heterosexual exposures for risk factors, the incidence actually increased. Also in 1995, the number of AIDS-related deaths declined for the first time. If these trends continue, we can expect a continued increase in the number of blacks living with AIDS. We estimate that 1% to 4% will develop renal failure from HIVAN. The incidence of HIVAN can be expected to increase unless new approaches are successful in preventing the spread of HIV-1 in all segments of the population or in treating the renal complications of HIV-1 infection. PMID: 9692350



    J Acquir Immune Defic Syndr. 2006 May;42(1):1-11.

    HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells.

    Ross MJ, Fan C, Ross MD, Chu TH, Shi Y, Kaufman L, Zhang W, Klotman ME, Klotman PE. Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA. michael.ross@mssm.edu
    HIV-associated nephropathy (HIVAN) is the most common cause of chronic renal failure in HIV-infected patients. Tubulointerstitial inflammation is a prominent component of the histopathology of HIVAN. The pathogenesis of HIVAN is a result of infection of renal epithelial cells, but the cellular response to this infection remains poorly defined. In these studies, we used oligonucleotide microarrays to identify differentially expressed genes in renal tubular epithelial cells from a patient with HIVAN at three time points after infection with vesicular stomatitis virus-pseudotyped gag/pol-deleted HIV-1. Very few genes were differentially expressed 12 and 24 hours after infection. Three days after infection, however, 47 genes were upregulated by at least 1.8-fold. The most prominent response of these cells to HIV-1 expression was production of proinflammatory mediators, including chemokines, cytokines, and adhesion molecules. Many of the upregulated genes are targets of interleukin 6 and nuclear factor kappa B regulation, suggesting a central role for these proteins in the response of tubular epithelial cells to HIV-1 infection. Analysis of kidneys from HIV-1 transgenic mice revealed upregulation of many of the proinflammatory genes identified in the microarray studies. These studies provide novel insights into the mechanisms by which HIV-1 infection of tubular epithelial cells leads to tubulointerstitial inflammation and progressive renal injury. PMID: 16763488





    HTLV-1 also implicated…


    Adult T cell leukemia in hemodialysis patients from the Kagoshima district, an area in which human T cell leukemia virus type I is highly endemic.

    We report 2 cases of adult T cell leukemia (ATL) from hemodialysis (HD) patients with chronic renal failure (CRF) in the Kagoshima district, an endemic area of human T cell leukemia virus type I(HTLV-I) in Japan. The positivity of antibodies to ATL-associated antigen(anti-ATLA) in HD patients, regardless of whether or not blood transfusions were given, has been higher than in healthy persons in the district (p less than 0.01). ATL is considered to break out from HTLV-I carriers. Further study should be conducted to clarify the relationship between HTLV-I infection and CRF, and moreover, attention should be directed not only to treatment of HD but accompanying ATL as well, particularly in HTLV-I-endemic areas. Uematsu T, Hanada S, Saito T, Otsuka M, Komidori K, Osaki K, Uemura S, Ueda H, Harada R, Hashimoto S. Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan. Nephron. 1989;51(2):257-60.
    PMID: 2915764



    as well as feline retrovirus…

    J Am Vet Med Assoc. 2010 Feb 15;236(4):424-9.

    Association between naturally occurring chronic kidney disease and feline immunodeficiency virus infection status in cats.

    White JD, Malik R, Norris JM, Malikides N. Faculty of Veterinary Science, University of Sydney, NSW, Australia. J.White@massey.ac.nz
    OBJECTIVE: To investigate the association between naturally occurring chronic kidney disease (CKD) and FIV infection status in cats in Australia. DESIGN: Case-control study. ANIMALS: 73 cats with CKD and 69 cats without historical, physical, or clinicopathologic evidence of CKD. PROCEDURES: Cats were tested for serum antibodies against FIV glycoprotein 40 (gp40) by use of an immunomigration assay. Information regarding age, breed (purebred or domestic), and sex was obtained from medical records. Analysis was performed on data from cats stratified into 2 age categories (< 11 years old and >or= 11 years old). Univariable and then multivariable analyses were performed to investigate the relationship between CKD and the study variable (FIV infection), the latter analysis accounting for breed (purebred or domestic), sex, and veterinary hospital of origin. RESULTS: Results of multivariable analysis revealed that younger cats with CKD (< 11 years old) were significantly more likely to have positive test results for serum antibodies against FIV gp40 than were cats without CKD. No significant associations were found between CKD and FIV infection, breed, sex, or hospital of origin among older (>or= 11 years old) cats in the multivariable analysis. CONCLUSIONS AND CLINICAL RELEVANCE: Among cats < 11 years of age, those with CKD were significantly more likely to have positive test results for serum antibodies against FIV gp40 than were cats without CKD. It cannot be definitively established from results of this study whether infection with FIV preceded the development of CKD, and the role, if any, of FIV in the establishment or progression of CKD remains to be determined.
    PMID: 20151865
     
  3. jeffrez

    jeffrez Senior Member

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    Well, yes it is, very obviously. CFS did not kill the person, the kidney failure did. It's just an opinion that CFS played a role, because it's impossible to say that the person wouldn't have had kidney failure without CFS. CFS is not a cause of death.

    "Acute aneuric renal failure due to dehydration arising as a result of CFS," could very well be "Acute car crash injuries due to blindness arising as a result of glaucoma." Are you saying that the cause of death was glaucoma? Obviously that's idiotic. The person died from the injuries sustained in the car crash, not because she had glaucoma. In the same way, CFS is not a "cause of death," the kidney failure was from dehydration.

    For all we know, the ME could have meant that the person was too tired to drink and died from the dehydration. That's about as much a cause of death as saying schizophrenia killed someone because they were delusional and didn't drink anything because they thought someone was trying to poison them. The cause of death is kidney failure from dehydration, not schizophrenia.

    No matter how you look at it, you're wrong. You're not reading the sentence correctly grammatically for your most basic error, and then your interpretation of what you're reading is also faulty. You are wrong. Normally I don't push the point home like that, but I've already asked the moderator to put an end to this pointless off-topic sidetrack, only to find that the moderator is now *participating* in it. So I am forced to state it more forcefully: You are wrong. Your interpretation is incorrect, your reasoning is faulty, and you are wrong.
     
  4. jeffrez

    jeffrez Senior Member

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    This is just completely absurd. Can we get another moderator in here please?
     
  5. lansbergen

    lansbergen Senior Member

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    Mr Kite

    I wonder whether you also think flu is not a cause of death because patients get lungfailure.
     
  6. jeffrez

    jeffrez Senior Member

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    Does it really matter? This off-topic haranguing is pointless and absurd. The "v99" person is upset because in the other thread I said Mikovits was hysterical in her recent comments, and she is taking out her frustration in this thread with this absurd and completely out of line nitpicking. It has nothing to do with anything. Please, just drop it.
     
  7. lansbergen

    lansbergen Senior Member

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    I think I may judge that for myself.
     
  8. jeffrez

    jeffrez Senior Member

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    So then please tell us: what does it have to do with anything? Especially since I made abundantly clear in my original post my respect for JDJ's medical training and intellectual acumen in making whatever decision she felt was right FOR HER, in HER SITUATION? Going so far as to say that in extreme circumstances I would even have a different opinion from my sensibly conservative general initial opinion?

    "v99" is upset because I said Mikovits sounds hysterical in her recent comments. So she came into this thread to nitpick on a non-existent point. That's what this is about. I think it's time to drop it now.
     
  9. lansbergen

    lansbergen Senior Member

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    I don't see what this has to do with my question.
     
  10. leaves

    leaves Senior Member

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    lets try to go back to the topic. I am pretty excited that Dr Deckoff seems to do better on the meds. It gives me hope.
    When do you guys think it would be realistic for me to get into a clinical trial (I am xmrv+) I am SOOOOO ready....
     
  11. V99

    V99 *****

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    You cannot be serious, come on, I post on most of these threads. Don't get your knickers in a bunch. I'm not upset about anything, well apart from the ME thing. As for nitpicking, again are you been serious. Seriously what. come on. It's just a disagreement. I would not deliberately target someone on here, so I'm sorry, (and I always hate it when someone puts this) if you feel that way, but I wasn't. :hug: no :(:hug:
     
  12. glenp

    glenp "and this too shall pass"

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    Vancouver Canada suburbs
  13. shannah

    shannah Senior Member

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    Looking very promising eh?
     
  14. Gemini

    Gemini Senior Member

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