Now there are two questions I feel needs answering to unravel this disease. The first being why such different things as a vaccine, EBV and giardia can trigger the disease. That's discussed above. The second thing is why is this disease so much more prevalent now, than fifty or a hundred years ago? My hypothesis for the last question, and this is uncertain, is that the retrovirus/RNA virus behind the disease has the gut as it's reservoir. And the virus has been one of many latent viruses being in humans for a very long time. But because the ecology of the gut have changed so radically the last century, and at least decades, we're now in a totally different situation. Now, what used to be a protective gut ecology, just isn't there anymore in many cases. It's highly changed. The reason for the gut ecology changes (gut flora changes) which mankind (at least in Western parts of the world) have seen, is because of what evolutionary can be definded as getting huge amounts of refined carbs every year. Now I am not saying eat well and all will be well (like in a cure). I don't think it's that easy. But I do think this could be one of the most important reasons we're seeing more of these diseases in Western countries (poorer prevalence studies in non Western countries can't account for all of the difference), and I think it's the reason why the diseases (CFS, FMS, RA, MS etc) are much more prevalent now than fifty years ago.