I'd really like to hear what you guys think of this: - Might it be that most of the CFS symptoms come from unwanted microbes in the gut? Sounds far fetched? Here's how I think it may be: We all (healthy and sick people) have different types of microbes in the gut. And when some of those microbes get the chance to overgrow, the person get's ill. That's the case when someone get's c. difficile. The body can handle the disease in some cases, in others it can't. The body is in a constant struggle trying to get wanted microbes to outnumber the unwanted ones. If the unwanted microbes get to grow, and really establish themselves, it can seem like an impossible task for the body to clear that out by itself. Here's what a microbes in the gut sample could look like: As you can see, we have much of some, and few of others. And if that balance shifts. I guess we can really be in trouble. What happens if the unwanted ones, some specific unwanted ones can outgrow the wanted ones? - We can get severe problems with the breakdown of dopamin and noradrenaline. What this means, is that if we try to concentrate mentally for some minutes, we will get really high levels of those substances, which in turn would make us feel really ill. - There is a large possibility that we could get uncomfortable socializing. Just like the mice who got the wrong microbes in the gut, we may also feel uncomfortable in new situations. - We could get lots of memory problems, vision problems, problems with a overactive immune system and other things because the body (meaning immune system) is constantly fighting this pathogenically high levels of the unwanted microbes. Now. How does all of this match with XMRV? Well, it's not hard to imagine that a immune suppressive virus could make it a lot harder for the body to get the microbes in the gut under control. How does this match with psychological stress (making CFS worse)? Stress may defiantly alter the body's (meaning immune system's) ability to keep the unwanted microbes in the gut under control. This could also be the case for vaccines. How does this match with HHV-6, EBV, and other infections? Everything which effects the immune system makes it harder for the body to keep this under control. And stuff like HHV-6, EBV and others can give symptoms on their own. High levels of clostridia bacteria have also been linked to autism. It may be that a major reason for autism is that something (such as a virus) messes with the body's ability to keep unwanted gut microbes at bay, and when the unwanted ones grow, and get the upper hand, they change how the brain developes (in early child stage)/or causes ongoing autism symptoms because it's active for the rest of their lives as well. So, what if it's all (or mostly, is a more appropriate word) in the gut? Results from Australia show that CFS (and MS, parkinson and RA) gets a whole lot better, when they just replace the gut bacteria... Please be the devils advocate. Please try to think of things which might disprove my hypothesis. Tell me what I've overlooked, or why I might be wrong. Thanks!