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"It Takes Guts:" Lipkin - Hornig - Autism Research

Discussion in 'Other Health News and Research' started by Forbin, Apr 16, 2016.

  1. Forbin

    Forbin Senior Member

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    I'm not sure if this article has been discussed before, but it appeared in the November 2015 edition of Columbia Public Health.

    It Take Guts: Scientists Delve Into the Role of Intestinal Microbes in Autism.
    https://www.mailman.columbia.edu/public-health-now/news/it-takes-guts

    The article discusses efforts at Columbia University by Drs. Bresnahan, Hornig, Susser, Lipkin et al., to investigate the possible involvement of the microbiome in some cases of autism, as discussed earlier in their May 2015 paper in JAMA Psychiatry:

    Association of maternal report of infant and toddler gastrointestinal symptoms with autism: evidence from a prospective birth cohort.
    http://www.ncbi.nlm.nih.gov/pubmed/25806498


    ...and in this 2011 paper in PLoS One, by Drs. Williams, Hornig, Lipkin, et al.:

    Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024585




    Obviously, this is also intriguing in light of their interest in the mircobiome and its possible relationship to ME/CFS.
     
    Last edited: Apr 20, 2016
  2. SB_1108

    SB_1108 Senior Member

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    From the It Takes Guts Article:
     
    Bob likes this.
  3. SB_1108

    SB_1108 Senior Member

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    I've found digestive enzymes to be one of the main things to give me some relief so I've been doing a little more research on this and based on the article there are two major deficiencies noted in the article:
    Disaccharidase enzymatic and hexose transporters

    I know absolutely nothing about hexose transporters but disaccharidase enzymes includes:
    Sucrase, Maltase, Lactase

    Klaire Labs has developed a digestive enzyme supplement to address this specific concern:
    http://www.klaire.com/enzymesforgi_vz.htm

    And here is another by Integrative Therapeutics:
    http://www.integrativepro.com/Products/Enzymes/Similase

    I'll do some self-experimentation and report back! :)
     
    green_monster likes this.
  4. Forbin

    Forbin Senior Member

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    One thing that strikes me is that has been some speculation that ME is initiated by "two strikes," i.e. you have some existing predisposition that sets you up for a fall if you happen to get some kind of acute infection (perhaps almost any kind of acute infection).

    What if that predisposition is a disrupted microbiome?

    This would be the opposite of the idea that an acute infection disrupts the microbiome and that then leads to ME.

    It might also make more sense in term of how rapidly ME manifests when triggered by an infection. I don't know, but I would expect an alteration in the microbiome to take some time to evolve, but that wouldn't be an issue if the microbiome was already altered at the time of infection.
     
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  5. SB_1108

    SB_1108 Senior Member

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    K - reporting back... tried it. Didn't help, made me feel worse, moving on! :(:(:(
     
  6. rosie26

    rosie26 Senior Member

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    I think I'm in the infection with disrupted microbiome subgroup firstly - then years later taking hits via flu, stress, then lead me to full-blown ME. I don't understand the sudden ME's and how it all transpired for them though.
     
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  7. Justin30

    Justin30 Senior Member

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    This is how some Drs think....same point as you mentioned with your illness.
     
    rosie26 likes this.
  8. rosie26

    rosie26 Senior Member

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    Yes, I'm really thrilled we have researchers that are studying this now.
     

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