Having translated 23andme results to Yasko's Nutrigenomics Panel format, I decided to go down the rabbit hole and investigate additional biochemical pathway screw ups. Two things became very clear very fast: Yasko's methylation map is quite simplified. A slightly more complicated but still simplified would be this one-carbon metabolism diagram. For many of the genes described in Yasko's Nutrigenomics, there are a bunch more mutations than the ones tested. For example, for CBS, there are a bunch of mutations that downregulate the enzyme's activity. The data on omim clearly illustrates this. Given just these two observations, it would seem to me that Yasko's Nutrigenomics Panel is nothing but the tip of the iceberg. It also seems to me that what is not shown/known might have quite a bit of influence. I am starting to feel that more important than looking at a limited number of genes and mutations, an actual methylation blood test is way more important and way more telling of one's status.