http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246686/ This research paper describes a disease which has been classified differently from ME, but the authors admit that this classification also includes CFS/ME signs and symptoms. This disease is caused by an autoimmune reaction to aluminium containing vaccine adjuvants. The systemic effects pain, fatigue, cognitive deficits, exactly describe classic ME symptoms, and can be accurately diagnosed by muscle biopsy at the site of vaccination. This autoimmune reaction has been reported for many years and is recognised by the WHO, who have studied it. Aluminium is not only a potent immune stimulant at the site of injection but also travels round the body, including the brain, and causes systemic (body-wide) immune reactions and disease. There are ways to chelate aluminium out of the body, so it is possible that we can do something to help ourselves. Chris Exley's website explains much of the science behind aluminium and its effect on the body, and also how you can reduce the load by drinking a silicon rich mineral water.