Hunting down the cause of ME/CFS & other challenging disorders - Lipkin in London
In a talk to patients in London on 3rd September, Dr. W. Ian Lipkin described the extraordinary lengths he and his team are prepared to go to in order to track down the source of an illness, with examples ranging from autism to the strange case of Kawasaki disease.
Discuss the article on the Forums.

Is there research on viral-neurological connection in ME/CFS?

Discussion in 'Latest ME/CFS Research' started by Dreambirdie, Dec 17, 2013.

  1. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,150
    Likes:
    3,440
    N. California
    Is there a paper that elucidates the viral-neurological connection in ME/CFS?

    A friend of mine doesn't understand why I don't have overt viral symptoms (runny nose, sore throat, fever, etc) when I have viral infections. They affect me primarily neurologically and seem to go straight to my brain, disrupting my sleep, my concentration, my coordination, and my energy.

    As I understand it the herpes viruses (EBV, CMV, HHV6) tend to live in the nervous system and when they are activated, it can cause the type of symptoms mentioned above. Anything that undermines my immune system (including garden variety cold and flu bugs) can activate the herpes viruses.

    I would like to know if this explanation is written up somewhere...?

    thanks.
     
    leela likes this.
  2. dannybex

    dannybex Senior Member

    Messages:
    2,338
    Likes:
    597
    Seattle
    I think the reason we don't have typical viral (or whatever) symptoms is due to the immune system abnormalities or dysfunction (that may be caused by other things like environmental toxins, heavy metal burdens, etc). So if you could find studies that note the difference in cellular vs humoral immunity, that might help explain it?Here's one, but there should be better ones out there:

    http://www.ncbi.nlm.nih.gov/pubmed/2787888

    and another…

    http://jcm.asm.org/content/28/6/1403.short
     
    leela, WillowJ and Dreambirdie like this.
  3. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,150
    Likes:
    3,440
    N. California
    Thanks Dan.
     
  4. Ema

    Ema Senior Member

    Messages:
    3,536
    Likes:
    4,099
    Midwest USA
    This was all I found but it isn't quite on point.

    Herpes virus infection of the peripheral nervous system.
    Authors
    Steiner I.
    Journal
    Handb Clin Neurol. 2013;115:543-58. doi: 10.1016/B978-0-444-52902-2.00031-X.

    Affiliation
    Abstract

    Among the human herpes viruses, three are neurotropic and capable of producing severe neurological abnormalities: herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Both the acute, primary infection and the reactivation from the site of latent infection, the dorsal sensory ganglia, are associated with severe human morbidity and mortality. The peripheral nervous system is one of the major loci affected by these viruses. The present review details the virology and molecular biology underlying the human infection. This is followed by detailed description of the symtomatology, clinical presentation, diagnosis, course, therapy, and prognosis of disorders of the peripheral nervous system caused by these viruses.

    I can pull the paper if you are interested.
     
    leela and Dreambirdie like this.
  5. Marco

    Marco Old blackguard

    Messages:
    1,491
    Likes:
    1,170
    Near Cognac, France
    leela and Dreambirdie like this.
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    4,280
    Likes:
    5,128
    Cornwall, UK
    Maybe vagus nerve infection, assuming that you do actually have a viral infection?
     
    Dreambirdie likes this.
  7. WillowJ

    WillowJ Senior Member

    Messages:
    3,202
    Likes:
    2,968
    WA, USA
    Dreambirdie likes this.
  8. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,150
    Likes:
    3,440
    N. California
    No t necessary, but good to see the title.
     
  9. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,150
    Likes:
    3,440
    N. California
    These have all been helpful. Thank you everybody.
     
    WillowJ likes this.
  10. Hip

    Hip Senior Member

    Messages:
    3,423
    Likes:
    3,352

    I think this is a case where the question itself is more important that any specific answer. The question highlights the fact that although there is good evidence of chronic infection in ME/CFS patients, the mechanism by which this infection precipitates the cognitive and mental symptoms we experience in ME/CFS has not been well elucidated.

    There ought be more research into how an infection can precipitate ME/CFS symptoms.


    Though one recently published paper by Michael VanElzakker attempts to do this. VanElzakker notes that sickness behavior symptoms (which are defined as the mental and physical symptoms you get when you come down with a nasty acute infection, like the flu) are very similar to ME/CFS symptoms. Sickness behavior can be thought of as a built-in response to infection.

    VanElzakker describes a mechanism by which the low level chronic infections of ME/CFS may trigger the sickness behavior response: VanElzakker suggests that the vagus nerve, which is known to be the main trigger and mediator of sickness behavior, actually becomes infected itself, and this infection of this nerve constantly triggers sickness behavior in the brain, leading to all the symptoms we experience in ME/CFS.
     
    Last edited: Dec 18, 2013

See more popular forum discussions.

Share This Page