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Is there BH4 supplement/medicine?

Discussion in 'Genetic Testing and SNPs' started by tim0011, Mar 23, 2013.

  1. tim0011

    tim0011

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    I'm homozygous for MTHFR 1298 and also have almost all BHMTs homozygous & both CBS heterozygous so I'm probably very deficient in BH4 since it's not created much and what is created is used up for detoxing ammonia.

    Do you know if there is a BH4 supplement or a medicine or something that would contain BH4? Thanks!
     
  2. beaverfury

    beaverfury beaverfury

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    West Australia
    http://www.iherb.com/Cardiovascular-Research-Ltd-Norival-120-Capsules/23532

    This is the closest i can find, though technically it's biopterin and not tetrahydrobiopterin(BH4). Not sure if that is useful.

    Unfortunately it's got tyrosine in it which tends to make me a little agitated.

    Triffid 333 has lots of good info on BH4 if you search her posts
     
  3. beaverfury

    beaverfury beaverfury

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    West Australia
    http:/

    http://www.iherb.com/Cardiovascular-Research-Ltd-Norival-120-Capsules/23532

    This is the closest i can find. Though technically this is biopterin not tetrahydrobiopterin (BH4). Not sure if that works the same.

    I have taken this and it tends to make me agitated. Probably the tyrosine.

    Triffid 333(?) knows a bit about BH4 if you search her posts.
     
  4. aquariusgirl

    aquariusgirl Senior Member

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    Check my earlier posts for a us compounding pharmacy that supplies it. Don't think they wld ship overseas. U cld ask
     
  5. aquariusgirl

    aquariusgirl Senior Member

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  6. Rolo

    Rolo Too ill to twist

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    Antwerp, Belgium

    The wikipedia page for Tetrahydrobiopterin mentions Kuvan as brand name. Maybe that's on option, but I'm not sure. It was just something I came across when I was doing my own research

    http://en.wikipedia.org/wiki/Tetrahydrobiopterin
    http://www.kuvan.com/
    According to http://www.rxlist.com/kuvan-drug.htm
    Sapropterin dihydrochloride , the active pharmaceutical ingredient in Kuvan (saproterin dihydrochloride tablets) Tablets, is a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4). Sapropterin dihydrochloride is an off-white to light yellow crystals or crystalline powder.

    Best Regards, Rolo
     
  7. August59

    August59 Daughters High School Graduation

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    Upstate SC, USA
    Be careful taking pure BH4 or a complex containing it. Some of the people on the MTHFR forum have had some bad side effects, but I don't know the whole story behind them. Here is the link to the website thread that prompted my concern. I might be talking about apples and oranges too:

    http://mthfr.net/forums/topic/bh4-supplement-for-a1298c/
     
  8. caledonia

    caledonia

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    Be cautious about taking BH4 unless you've addressed CBS and BHMT first. See the Heartfixer page (the link is in my signature):

    Elsewhere on the page, he talks about metals blocking BH4. So checking for metals and chelation might be in order too before trying BH4.
     
  9. aquariusgirl

    aquariusgirl Senior Member

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    hmm... I am getting more detox with BH4.. but I'm not crashing..and it seems to be helping with cognitive stuff. I take it with lithium though... didn't notice the same effects taking it on its own.

    :thumbdown:hmm.. penny may have just dropped.. maybe if you take BH4 w/'out lithium, it just runs your lithium down more....

    see james clellands paper on Bh4 & lithium
     
  10. Rolo

    Rolo Too ill to twist

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    Antwerp, Belgium
    Hi Aquariusgirl,

    Nice to hear that BH4 is somehow working for you. If you cognitive functions are improving, how would you then describe your detox symptoms?

    What product (brand) do you take?

    Thanks,
    Rolo
     
  11. kakrpa

    kakrpa

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    Any sources I've come across, in postings, for purchasing BH4 are either broken web links, or the product is no longer available. Anyone know of somewhere the purchase this? I've even contacted Pharmaworld in Zurich - they can't sell it either. Before this was so scarce, did anyone try this for their A1298C (I have no CBS, etc. issues) and possibly anxiety/low BH4 levels? If so, how did it go?

    Also, **I am not recommending anyone buy this by any means**, but I'm curious how this compound is different from the kind meant for human consumption, or as was previously available. Note: this product page clearly warns that it is not for human nor veterinary use!
    https://www.caymanchem.com/app/template/Product.vm/catalog/81880
     
  12. kakrpa

    kakrpa

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    @aquariusgirl are you still taking BH4? Curious if u are, how much, what r the benefits. If not, why not, etc. :)
     
  13. Mimi

    Mimi Senior Member

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    Yes. http://www.spectrum-supplements.com/tetrahydrobiopterin-60-capsules.html
    The price is $55.
     
  14. Mimi

    Mimi Senior Member

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    BH4 was extremely helpful to me. I was had been taking s-acetyl glutathione for about a year and had done a lot of mercury detox (Cutler) and other supports (minerals, idebenone, virus-killing herbs and supplements).

    I also gave some to my ME/CFS friends. One friend, who ordered it on her own, found it reduced her chemical sensitivity. She has severe MCS. Other friends felt their moods improve noticably within an hour or two. Another friend, who has severe orthostatic intolerance, found that his blood pressure dropped dramatically. He's now trying it again and is going to start low and go slow this time, like our friend with MCS.

    After a few months of good recovery, I stopped getting a response to BH4 and quit taking it. But I may try it again soon, as my mood is rather low today and I'm extremely tired. That could also be because I ran out of s-acetyl glutathione, and because I'm doing some deep emotional/energetic clearing right now. In general, my health is quite good and I feel metal detoxification was the key. Perhaps it's all that Fiji water that I took to detox aluminum this fall.


    Mimi
     
    Last edited: Dec 6, 2013
  15. kyzcreig

    kyzcreig

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    That's great! How much do you take, isn't 2.5mg too small a dose?
     
  16. Mimi

    Mimi Senior Member

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    No, it's quite effective. I take it with l-tyrosine to get more dopamine out of it. I also take it twice a day.
     
  17. kyzcreig

    kyzcreig

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    Thanks.
     
  18. kyzcreig

    kyzcreig

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    Just wanted to say I've gotten BH4 and, in conjunction with 5MTHF, it seems to be helping.
     
  19. heatherfeather7983

    heatherfeather7983

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  20. Mimi

    Mimi Senior Member

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    Ashland, OR

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